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Effects of Aging on Immune Function

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Principles and Practice of Geriatric Surgery

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Abstract

In this chapter we describe changes in the immune system that are thought to be related to age per se. We subsequently review the clinical implications of these changes, including the effects of surgical trauma on immune function (see the physiology table at beginning of chapter). We then discuss how stress modifies many of these changes. We also describe recent information on persistent infections, in particular latent viral infections and how they may be partly responsible for shaping the aging immune system. We conclude with a discussion of some of the latest research on ways to restore or stimulate immune function in the elderly.

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Authors and Affiliations

  1. Microgen Laboratories, La Marque, TX, USA

    Raymond P. Stowe

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  1. Raymond P. Stowe
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  2. James S. Goodwin
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Correspondence to Raymond P. Stowe .

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  1. School of Medicine, Department of Surgery, Yale University, New Haven, 06520, Connecticut, USA

    Ronnie Ann Rosenthal

  2. Downstate Medical Center, State University of New York, Clarkson Ave. 450, Brooklyn, 11203, New York, USA

    Michael E. Zenilman

  3. , Chairman, Department of Surgery, Sinai Hospital, 2401 West Belvedere Avenue, Baltimore, 21215, Maryland, USA

    Mark R. Katlic

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Stowe, R.P., Goodwin, J.S. (2011). Effects of Aging on Immune Function. In: Rosenthal, R., Zenilman, M., Katlic, M. (eds) Principles and Practice of Geriatric Surgery. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-6999-6_4

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