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Endoplasmic Reticulum Stress and BCL-2 Family Members

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BCL-2 Protein Family

Part of the book series: Advances in Experimental Medicine and Biology ((volume 687))

Abstract

In the eukaryotic cell, the endoplasmic reticulum (ER) plays an important role as the site of lipid synthesis, protein folding and protein maturation. Stringent regulation of redox and calcium homeostasis is paramount, failure of which leads accumulation of unfolded and aggregating proteins resulting in a condition known as ER stress. Eukaryotic cells deal with ER stress by eliciting the unfolded protein response (UPR). This pathway splits into two streams depending on the severity and longevity of the ER stress, where the cell must make a choice for the good of the organism between survival and programmed cell death. The BCL-2 family of proteins is central to the cell death arm of the UPR pathway. This chapter discusses the recent findings on the involvement of BCL-2 family members in the apoptotic process initiated by ER stress and a related process called autophagy. Understanding the molecular mechanisms involved in ER stress and autophagy could have a profound implications developing new therapies for many ER stress associated diseases and cancer.

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Authors and Affiliations

  1. Department of Biochemistry, School of Molecular Sciences, La Trobe University, Bundoora, Australia, 3086

    Ross T. Weston & Hamsa Puthalakath

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  1. Ross T. Weston
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  2. Hamsa Puthalakath
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Correspondence to Hamsa Puthalakath .

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Editors and Affiliations

  1. Institute of Biomedical Sciences, FONDAP Center for Molecular Studies of the Cell (CEMC) Millennium Nucleus for Neural Morphogenesis (NEMO), University of Chile, Santiago, Chile

    Claudio Hetz PhD

  2. Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts, USA

    Claudio Hetz PhD

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Weston, R.T., Puthalakath, H. (2010). Endoplasmic Reticulum Stress and BCL-2 Family Members. In: Hetz, C. (eds) BCL-2 Protein Family. Advances in Experimental Medicine and Biology, vol 687. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-6706-0_4

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