BCL‑2 Protein Family

1. Front Matter

   Pages i-xvii

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2. Homeostatic Functions of BCL-2 Proteins beyond Apoptosis

   • Nika N. Danial, Alfredo Gimenez-Cassina, Daniel Tondera

   Pages 1-32

3. Alternative Functions of the BCL-2 Protein Family at the Endoplasmic Reticulum

   • Diego Rojas-Rivera, Benjamin Caballero, Sebastian Zamorano, Fernanda Lisbona, Claudio Hetz

   Pages 33-47

4. BH3-Only Proteins and Their Effects on Cancer

   • Thanh-Trang Vo, Anthony Letai

   Pages 49-63

5. Endoplasmic Reticulum Stress and BCL-2 Family Members

   • Ross T. Weston, Hamsa Puthalakath

   Pages 65-77

6. Targeting Survival Pathways in Lymphoma

   • Luca Paoluzzi, Owen A. O’Connor

   Pages 79-96

7. The Interplay between BCL-2 Family Proteins and Mitochondrial Morphology in the Regulation of Apoptosis

   • Maria Eugenia Soriano, Luca Scorrano

   Pages 97-114

8. Noncanonical Functions of BCL-2 Proteins in the Nervous System

   • Heather M. Lamb, J. Marie Hardwick

   Pages 115-129

9. Mitochondria on Guard: Role of Mitochondrial Fusion and Fission in the Regulation of Apoptosis

   • Mariusz Karbowski

   Pages 131-142

10. Back Matter

    Pages 143-145

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In this book, scientists pioneering the field have compiled a series of focused chapters to highlight the relevance of the BCL‑2 family of proteins in apoptosis, physiology and disease. An important focus of this volume is considering the potential TH ERA PEUT IC benefits of targeting apoptosis pathways in the context of human disease. Readers interested in understanding how a cell handles stress and the consequences of dysregulation of this process for human disease will find this book very valuable. It attempts to describe a fascinating area of research where physiology and biomedicine converge at different levels, revealing a trip from the molecular regulation of apoptosis to the impact of this process to the physiology of a whole organism.

• Apoptosis
• Biomedicine
• Cell
• Hetz
• Protein
• Regulator
• cells
• dynamics
• physiology
• protein family
• regulation

• Institute of Biomedical Sciences, FONDAP Center for Molecular Studies of the Cell (CEMC) Millennium Nucleus for Neural Morphogenesis (NEMO), University of Chile, Santiago, Chile

  Claudio Hetz

• Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, USA

  Claudio Hetz

Claudio Hetz received his BA in Biotechnology Engineering from the University of Chile in 2000. In his PhD work with Claudio Soto at Serono Pharmaceutical Research Institute, Geneva, he showed that Prion pathogenesis involves endoplasmic reticulum stress responses and apoptosis. In 2004 he joined as a postdoctoral fellow Stanley Korsmeyer’s lab at Dana‑Farber Cancer Institute, a pioneer in the apoptosis field. Together they discovered new functions of the BCL‑2 family in organelle physiology. Dr. Hetz followed his projects in Laurie Glimcher’s lab at Harvard. During this period he expanded his studies on neurodegeneration, addressing the connection between apoptosis and the unfolded protein response in vivo. Since 2007 he is an Assistant Professor at the University of Chile and adjunct professor at Harvard. His lab uses animal models to investigate the signaling responses involved in protein misfolding disorders and the role of the BCL‑2 protein family in stress conditions. He was recently awarded with the TWAS‑ROLAC Young Scientist Prize, also as finalist with the Eppendorf and Science Award in Neurobiology, and other important recognitions.

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