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Role of Amide Proton Transfer (APT)-MRI of Endogenous Proteins and Peptides in Brain Tumor Imaging

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Functional Brain Tumor Imaging

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Abstract

Amide proton transfer (APT) imaging is a novel molecular MRI technique that can provide endogenous contrast related to mobile protein content in tissue. The preclinical studies and pilot clinical data have shown initial potential for APT imaging to assess brain tumors, such as differentiating between tumor and peritumoral edema, separating high- from low-grade gliomas, and distinguishing between active tumor and radiation necrosis. In this chapter, we briefly introduce the basic principle of APT imaging and overview its current applications for brain tumor assessment in animal models and in patients.

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Acknowledgements

This study was supported in part by grants from NIH (EB009112, EB009731, EB015032, and RR015241).

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Authors and Affiliations

  1. Department of Radiology, Johns Hopkins University School of Medicine, 720 Rutland Avenue, Trailer 217, Baltimore, MD, 21287, USA

    Silun Wang Ph.D., Samson Jarso Ph.D., Peter C. M. van Zijl Ph.D. & Jinyuan Zhou Ph.D.

  2. F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, USA

    Samson Jarso Ph.D., Peter C. M. van Zijl Ph.D. & Jinyuan Zhou Ph.D.

Authors
  1. Silun Wang Ph.D.
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  2. Samson Jarso Ph.D.
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  3. Peter C. M. van Zijl Ph.D.
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  4. Jinyuan Zhou Ph.D.
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Corresponding authors

Correspondence to Peter C. M. van Zijl Ph.D. or Jinyuan Zhou Ph.D. .

Editor information

Editors and Affiliations

  1. Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine and The Johns Hopkins Hospital, Baltimore, Maryland, USA

    Jay J. Pillai

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Wang, S., Jarso, S., van Zijl, P.C.M., Zhou, J. (2014). Role of Amide Proton Transfer (APT)-MRI of Endogenous Proteins and Peptides in Brain Tumor Imaging. In: Pillai, J. (eds) Functional Brain Tumor Imaging. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-5858-7_10

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  • DOI: https://doi.org/10.1007/978-1-4419-5858-7_10

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  • Online ISBN: 978-1-4419-5858-7

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