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Cancer Stem Cells and Radiation

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Targeted Radionuclide Tumor Therapy

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Summary

Cancer stem cells have recently been proposed to play a significant role in the initiation and propagation of tumor cells. They display indefinite self-renewal capacity and multilineage potential as well as an excessive proliferation capacity. Cancer stem cells are quiescent with low mitotic frequencies. They seem to be relatively radioresistant and have been demonstrated to increase in relative amount following radiotherapy. The stem cells express a number of marker molecules, which hopefully can be used for therapeutic purposes. These possibilities will be discussed in this chapter.

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Author information

Authors and Affiliations

  1. Departments of Immunology, Diagnostic Radiology and Radiophysics, University of Umeå, SE-90185, Umeå, Sweden

    David Eriksson, Katrine Riklund, Lennart Johansson & Torgny Stigbrand

Authors
  1. David Eriksson
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  2. Katrine Riklund
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  3. Lennart Johansson
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  4. Torgny Stigbrand
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Editor information

Editors and Affiliations

  1. Department of Immunology, University of Umea, Umea, Sweden

    Torgny Stigbrand

  2. Rudbeck Laboratory, Uppsala University, Uppsala, Sweden

    Jörgen Carlsson

  3. Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, USA

    Gregory P. Adams

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Eriksson, D., Riklund, K., Johansson, L., Stigbrand, T. (2008). Cancer Stem Cells and Radiation. In: Stigbrand, T., Carlsson, J., Adams, G.P. (eds) Targeted Radionuclide Tumor Therapy. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-8696-0_15

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