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General Introduction

  • Chapter
Risk Assessment of Chemicals

Over the last few decades there has been considerable activity in the field of risk assessment. This has mainly taken place in international bodies such as the Organization for Economic Co-operation and Development (OECD), the World Health Organization (WHO) - especially in the context of its International Programme on Chemical Safety (IPCS) - the European and Mediterranean Plant Protection Organization (EPPO), the Council of Europe and the European Centre for Ecotoxicology and Toxicology of Chemicals (ECETOC) [1-10]. Various directives and regulations in which risk assessment plays a crucial part have been issued by the European Community [11-14] and similar activities are taking place in other parts of the world, e.g., the U.S., Canada and Japan.

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References

  1. Organization for Economic Co-operation and Development. 1992. Report of the OECD workshop on quantitative structure-activity relationships (QSARs) in aquatic effects assessment. OECD Environment Monographs 58. OECD, Paris, France.

    Google Scholar 

  2. Organization for Economic Co-operation and Development. 1992. Report of the OECD workshop on the extra-polation of laboratory aquatic toxicity data to the real environment. OECD Environment Monographs 59. OECD, Paris, France.

    Google Scholar 

  3. Organization for Economic Co-operation and Development. 1992. Report of the OECD workshop on the application of simple models for environmental exposure assessment. OECD Environment Monographs 69. OECD, Paris, France.

    Google Scholar 

  4. Organization for Economic Co-operation and Development. 1993. Occupational and consumer exposure assessment. OECD Environment Monographs 69. OECD, Paris, France.

    Google Scholar 

  5. Mercier M. 1988. Risk assessment of chemicals: a global approach. In Richardson ML, ed, Risk Assessment of Chemicals in the Environment. Royal Society of Chemistry, Cambridge, UK, pp 73-91.

    Google Scholar 

  6. European and Mediterranean Plant Protection Organization and Council of Europe. 1993. Decisionmaking scheme for the environmental risk assessment of plant protection products. EPPO Bull 23:1-165.

    Google Scholar 

  7. European Centre for Ecotoxicology and Toxicology of Chemicals. 1992. Estimating environmental concentrations of chemicals using fate and exposure models. ECETOC Technical Report 50. Brussels, Belgium.

    Google Scholar 

  8. European Centre for Ecotoxicology and Toxicology of Chemicals. 1993. Environmental hazard assessment of substances. ECETOC Technical Report 51. Brussels, Belgium.

    Google Scholar 

  9. European Centre for Ecotoxicology and Toxicology of Chemicals. 2004. Soil and sediment risk assessment of organic chemicals. ECETOC Technical Report 92. Brussels, Belgium.

    Google Scholar 

  10. European Centre for Ecotoxicology and Toxicology of Chemicals. 2004. Targeted Risk Assessment. ECETOC Technical Report 93. Brussels, Belgium.

    Google Scholar 

  11. Commission of the European Communities. 1967. Council Directive 67/548/EEC of 18 August 1967 on the approximation of the laws, regulations and administrative provisions relating to the classification, packaging and labelling of dangerous substances. Off J Eur Communities, L96/1.

    Google Scholar 

  12. Commission of the European Communities. 1993. Council Regulation 793/93/EEC of 23 March 1993 on the evaluation and control of the risks of existing substances. Off J Eur Communities, L84/1.

    Google Scholar 

  13. Commission of the European Communities. 1991. Council Directive 91/414/EEC of 15 July 1991 concerning the placing of plant protection products on the market. Off J Eur Communities, L230/1.

    Google Scholar 

  14. Commission of the European Communities. 1993. Council Directive for biocides. 1993. Proposal of the Commission of the European Communities, COM(93) 351 def/SYN 465. Brussels, Belgium.

    Google Scholar 

  15. Patton DE. 1993. The ABCs of risk assessment. EPA Journal19:10-15.

    Google Scholar 

  16. United Nations. 1992. Environmentally sound management of toxic chemicals including prevention of illegal international traffic in toxic and dangerous products. Agenda 21, chapter 19. United Nations Conference on Environment and Development, Rio de Janeiro, Brazil.

    Google Scholar 

  17. Organization for Economic Co-operation and Development. 1981. Decision of the Council concerning mutual acceptance of data in the assessment of chemicals, Annex 2. OECD Principles of good laboratory practice. OECD, Paris, France.

    Google Scholar 

  18. Carnegie Commission on Science, Technology, and Government. 1993. Risk and the environment. Improving regulatory decisionmaking. Carnegy Commission, New York, NY.

    Google Scholar 

  19. European Centre for Ecotoxicology and Toxicology of Chemicals. 1988. Concentrations of industrial chemicals measured in the environment: The influence of physicochemical properties, tonnage and use pattern. ECETOC Technical Report 29. Brussels, Belgium.

    Google Scholar 

  20. McColl RS. 1990. Biological safety factors in toxicological risk assessment. Health and Welfare Canada, Ontario, Canada.

    Google Scholar 

  21. Vermeire T, Stevenson H, Pieters MN, Rennen M, Slob W, Hackert BC. 1999. Assessment factors for human health risk assessment: a discussion paper. Crit Rev Toxicol29:439-490.

    Article  CAS  PubMed  Google Scholar 

  22. Commission of the European Communities. 2003. Technical Guidance Document in support of Commission Directive 93/67/EEC on risk assessment for new notified substances, Commission Regulation (EC) No 1488/94 on risk assessment for existing substances and Directive 98/8/EC of the European Parliament and of the Council concerning the placing of biocidal products on the market. Joint Research Centre, European Chemicals Bureau, Brussels, Belgium.

    Google Scholar 

  23. Van De Meent D. 1988. Environmental chemistry: instrument in ecological risk assessment. In De Kruijff HAM, De Zwart D, Ray PK, Viswanathan PN, eds, Manual on Aquatic Ecotoxicology. Kluwer Academic Press, Dordrecht, The Netherlands, pp 31-35.

    Google Scholar 

  24. Bro-Rasmussen F. 1988. Hazard and risk assessment and the acceptability of chemicals in the environment. In Richardson ML, ed, Risk Assessment of Chemicals in the Environment. Royal Society of Chemistry, Cambridge, UK, pp 437-450.

    Google Scholar 

  25. Premises for Risk Management. 1989. Risk limits in the context of environmental policy. Annex to the Dutch National Environmental Policy Plan (to Choose or to Lose) 1990-1994. Second Chamber of the States General, session 1988-1989, 21137, No 5. The Hague, The Netherlands.

    Google Scholar 

  26. Van Leeuwen CJ. 1990. Ecotoxicological effects assessment in the Netherlands: recent developments. Environ Management14:779-792.

    Google Scholar 

  27. US Congress, Office of Technology Assessment. 1993. Researching health risks. OTA-BBS-571, Washington, DC.

    Google Scholar 

  28. Lave LB, Malès EH. 1989. At risk: the framework for regulating toxic substances. Environ Sci Technol23:386-391.

    Article  Google Scholar 

  29. Roberts LEJ. 1988. Risk assessment and risk accep-tance. In Richardson ML, ed, Risk Assessment of Chemicals in the Environment. Royal Society of Chemistry, Cambridge, UK, pp 7-32.

    Google Scholar 

  30. Tengs TO, Adams ME, Pliskin JS, Gelb Safran D, Siegel JE, Weinstein MC, Graham JD. 1995. Five-hundred lifesaving interventions and their cost-effectiveness. Risk Analysis15:369-390.

    Article  CAS  PubMed  Google Scholar 

  31. Commission of the European Communities. 1992. Council Directive 92/32/EEC of 30 April 1992 amending for the seventh time Directive 67/548/EEC on the approximation of the laws, regulations and administrative provisions relating to the classification, packaging and labelling of dangerous substances. Off J Eur Communities, L154/1.

    Google Scholar 

  32. United Nations. 2005. Globally harmonized system of classification and labelling of chemicals (GHS). First revised edition. United Nations, Geneva, Switzerland.

    Google Scholar 

  33. European Chemicals Bureau. 2005. Scoping study on the technical guidance document on preparing the chemical safety report under REACH. Reach Implementation Project 3.2. Report prepared by CEFIC, ECETOC, RIVM, the Federal Institute for Risk Assessment (BfR), Federal Institute for Occupational Safety and Health (BAuA), Okopol, DHI Water & Environment and TNO. European Commission, Joint Research Centre, Ispra, Italy.

    Google Scholar 

  34. De Zwart D. 1994. Monitoring water quality in the future. Part B. biomonitoring. National Institute of Public Health and Environmental Protection, Bilthoven, The Netherlands.

    Google Scholar 

  35. European Centre for Ecotoxicology and Toxicology of Chemicals. 2005. Guidance for the interpretation of biomonitoring data. ECETOC Document No 44. ECETOC, Brussels, Belgium.

    Google Scholar 

  36. European Environment Agency. 1999. Environment in the European Union at the turn of the century. Environmental assessment report No 2. European Environment Agency, Copenhagen, Denmark.

    Google Scholar 

  37. United Nations Environment Programme. 1995. Environmental management tools. Industry and Environment18:1-131.

    Google Scholar 

  38. World Health Organization. 2004. Environmental Health Indicators for Europe. A Pilot Indicator-based Report. WHO Europe, Copenhagen, Denmark.

    Google Scholar 

  39. US Environmental Protection Agency. 2004. Status and future directions of the High Production Volume Challenge programme. US Environmental Protection Agency. Office of Pollution Prevention and Toxics, Washington, DC.

    Google Scholar 

  40. Commission of the European Communities 2006. Regulation (EC) No 1907/2006 of the European Parliament and of the Council of 18 December 2006 concerning the Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH), establishing a European Chemicals Agency, amending Directive 1999/45/EC and repealing Council Regulation (EEC) No 793/93 and Commission Regulation (EC) No 1488/94 as well as Council Directive 76/769/EEC and Commission Directives 91/155/EEC, 93/67/EEC, 93/105/EC and 2000/21/EC. Off J Eur Union, L 396/1 of 30.12.2006.

    Google Scholar 

  41. US Presidential/Congressional Commission on Risk Assessment and Risk Management. 1997. Final Report, Volumes 1 and 2, Washington, DC.

    Google Scholar 

  42. US Environmental Protection Agency. 1998. Guidelines for Ecological Risk Assessment. Report EPA/630/R-95/002F. Fed Reg 63(93):26846-26924. USEPA, Washington, DC.

    Google Scholar 

  43. Codex Alimentarius Commission, 2003. Procedural Manual 14th edition. World Health Organization/Food and Agricultural Organization of the United Nations, Rome, Italy.

    Google Scholar 

  44. Bridges J. 2003. Human health and environmental risk assessment: the need for a more harmonised approach. Chemosphere 52:1347-1351.

    Article  CAS  PubMed  Google Scholar 

  45. Suter II GW, Vermeire T, Munns WR Jr, Sekizawa J. 2003. A framework for the integration of health and ecological risk assessment. Human Ecol Risk Assess 9: 281-301.

    Article  Google Scholar 

  46. Suter II GW, Vermeire T, Munns WR, Sekizawa J. 2005. An integrated framework for health and ecological risk assessment. Toxicol Applied Pharmacol Issue 2, (Suppl 1) 207:611-616.

    Article  CAS  Google Scholar 

  47. Suter GW II, Munns WR Jr, Sekizawa J. 2003. Types of integration in risk assessment and management, and why they are needed. Human Ecol Risk Assess 9:273-279.

    Article  Google Scholar 

  48. World Health Organization and International Programme on Chemical Safety. 2001. Report on Integrated Risk Assessment. WHO/IPCS/IRA/01/12. Geneva, Switzerland.

    Google Scholar 

  49. van Leeuwen C, Biddinger G, Gess D, Moore D, Natan T, Winkelmann D. 1998. Problem formulation. In Reinert KH, Bartell SM, Biddinger GR, eds, Ecological Risk Assessment Decision-Support System: A Conceptual Design. Proceedings from SETAC Ecological Risk Assessment Modelling Workshop 1994. Society of Environmental Toxicology and Chemistry (SETAC), Pensacola, Fl, pp 7-15.

    Google Scholar 

  50. Commission of the European Communities. 2004. Science in trade disputes related to potential risks: comparative case studies. Technical Report Series, EUR 21301 EN, Joint Research Centre, Institute for Prospective Technology Studies, Seville, Spain.

    Google Scholar 

  51. Van Zwanenberg P, Millstone E. 2005. BSE: Risk, Science, and Governance. Oxford University Press, Oxford, UK.

    Google Scholar 

  52. National Research Council. 1983. Risk assessment in the Federal Government: managing the process. National Academy Press, Washington, DC.

    Google Scholar 

  53. European Chemicals Bureau. 2005. Scoping study on the development of a technical guidance document on information requirements on intrinsic properties of substances (RIP 3.3-1). Report prepared by CEFIC, DK-EPA, Environmental Agency of Wales and England, ECETOC, INERIS, KemI and TNO. European Commission, Joint Research Centre, Ispra, Italy.

    Google Scholar 

  54. Majone G. 2000. The credibility crisis of community regulation. J Common Market Studies 38:273-303.

    Article  Google Scholar 

  55. Persson T. 2005. The role of scientific expertise in EU policy-making. In Hansen O, Ruden C, eds, Science for a safe chemical environment. Royal Institute of Technology, Stockholm, Sweden, pp 179-189.

    Google Scholar 

  56. Allio L, Ballantine B, Meads R. 2006. Enhancing the role of science in the decision-making of the European Union. Regul Toxicol Pharmacol 44:4-13.

    Article  PubMed  Google Scholar 

  57. Ballantine B. 2005. Enhancing the role of science in the decision-making of the European Union. EPC Working Paper 17. European Policy Centre, Brussels, Belgium.

    Google Scholar 

  58. US Office of Management and Budget. 2006. Proposed Risk Assessment Bulletin. Draft being released for peer review and public comment before 15-06-06. Washington, DC.

    Google Scholar 

  59. Bradbury S, Feijtel T, van Leeuwen K. 2004. Meeting the scientific needs of ecological risk assessment in a regulatory context. Environ Sci Technol 38/23, 463a-470a.

    Article  Google Scholar 

  60. Posthuma L, Suter II GW, Traas TP. eds, 2002. Species Sensitivity Distributions in Ecotoxicology, Lewis Publishers. Boca Raton, Fl.

    Google Scholar 

  61. Lovell DP. 1986. Risk assessment - general principles. In Richardson ML, ed, Toxic Hazard Assessment of Chemicals. Royal Society of Chemistry, London, UK, pp 207-222.

    Google Scholar 

  62. Gow JS. 1990. Introduction. In Richardson ML, ed, Risk Assessment of Chemicals in the Environment. Royal Society of Chemistry, Cambridge, UK, pp 3-7.

    Google Scholar 

  63. Warren-Hicks W, Moore D, eds, Uncertainty Analysis in Ecological Risk Assessment. A Special Publication of SETAC. Society of Environmental Toxicology and Chemistry, Pensacola, Fl.

    Google Scholar 

  64. Suter GW. 1993. Ecological Risk Assessment. Lewis Publishers, Chelsea, MI.

    Google Scholar 

  65. Van Leeuwen CJ, Bro-Rasmussen F, Feijtel TCJ, Arndt R, Bussian BM, Calamari D, Glynn P, Grandy NJ, Hansen B, Van Hemmen JJ, Hurst P, King N, Koch R, Müller M, Solbé JF, Speijers GAB, Vermeire T. 1996. Risk assessment and management of new and existing chemicals. Environ Toxicol Pharmacol2:243-299.

    Article  Google Scholar 

  66. Allanou R, Hansen BG, Van Der Bilt Y. 1999. Public availability of data on EU high production volume chemicals. Report EUR 18996 EN, European Commission, Joint Research Centre, Ispra, Italy.

    Google Scholar 

  67. Ricci PF, Rice D, Ziagos J, Cox Jr LA. 2002. Precaution, uncertainty and causation in environmental decisions. Environ Internat29:1-19.

    Article  Google Scholar 

  68. Jager T, Vermeire TG, Rikken MGJ, van der Poel P. 2001. Opportunities for a probabilistic risk assessment of chemicals in the European Union. Chemosphere43:257-64.

    Article  CAS  PubMed  Google Scholar 

  69. Scheringer M, Steinbach D, Escher B, Hungerbuhler K. 2002. Probabilistic approaches in the effect assessment of toxic chemicals. What are the benefits and limitations? Environ Sci Pollut Res9:307-314.

    Article  CAS  Google Scholar 

  70. MacLeod, M, Fraser, AJ, MacKay, D. 2002. Evaluating and expressing the propagation of uncertainty in chemical fate and bioaccumulation models. Environ Toxicol Chem 4:700-709.

    Article  Google Scholar 

  71. Slob W, Pieters M. 1998. A probabilistic approach for deriving acceptable human intake limits and human health risks from toxicological studies: a general framework. Risk Analysis18:787-798.

    Article  CAS  PubMed  Google Scholar 

  72. Bodar CWM, Berthault F, De Bruijn JHM, Van Leeuwen CJ, Pronk MEJ, Vermeire TG. 2003. Evaluation of EU risk assessments of existing chemicals (EC Regulation 793/93). Chemosphere53:1039-1047.

    Article  CAS  PubMed  Google Scholar 

  73. Bodar WM, Pronk MEJ, Sijm DTHM. 2005. The European Union risk assessment on zinc and zinc compounds: the process and the facts. Integrated. Environ Assessm Managem1:301-319.

    Article  CAS  Google Scholar 

  74. Bosgra S, Bos PMJ, Vermeire TG, Luit RJ, Slob W. 2005. Probabilistic risk characterisation: an example with di(2-ethylhexyl)phthalate. Regul Toxicol Pharmacol43:104-113.

    Article  CAS  PubMed  Google Scholar 

  75. Jager T, Den Hollander HA, Van der Poel P, Rikken MGJ. 2001. Probabilistic environmental risk assessment for dibutylphtalate (DBP). Human Ecol RiskAss 7 (6):1681-1697.

    Article  CAS  Google Scholar 

  76. Verdonck AM, Aldenberg T, Jaworska J, Vanrolleghem PA. 2003. Limitations of current risk characterization methods in probabilistic environmental risk assessment. Environ Toxicol Chem22:2209-2213.

    Article  CAS  PubMed  Google Scholar 

  77. Weed DL. 2005. Weight of evidence: a review of concept and methods. Risk Analysis25:1545-1557.

    Article  PubMed  Google Scholar 

  78. Verdonck AM, Van Sprang PA, Jaworska J, Vanrolleghem PA. 2005. Uncertainty and precaution in European environmental risk assessment of chemicals. Water Sci Technol52:227-234.

    Article  CAS  PubMed  Google Scholar 

  79. Commission of the European Communities. 2005. EUSES 2.0, the European Union System for the Evaluation of Substances. European Chemicals Bureau (ECB) and National Institute of Public Health and the Environment (RIVM), Bilthoven, The Netherlands. Available from the ECB. European Chemicals Bureau, Ispra, Italy. (http://ecb.jrc.it/REACH/).

    Google Scholar 

  80. National Research Council. 1993. Issues in risk assessment. National Academy Press, Washington, DC.

    Google Scholar 

  81. De Bruijn J, Hansen B, Munn S. 2003. Role of the precautionary principle in the EU risk assessment process on industrial chemicals. Pure Appl Chem75:2523-2541.

    Google Scholar 

  82. Sandin P, Petersen M, Hanson SO, Ruden C, Juthe A. 2002. Five charges against the precautionary principle. J Risk Res5:287-299.

    Article  Google Scholar 

  83. Kriebel D, Tickner J, Epstein P, Lemons J, Levins R, Loechler EL, Quinn M, Rudel R, Schettler T, Stoto M. 2001. The precautionary principle in environmental science. Environ Health Persp 109:871-876.

    Article  CAS  Google Scholar 

  84. Commission of the European Communities. 2000. Communication from the Commission on the precautionary principle. COM (2000) 1 final. Brussels, Belgium.

    Google Scholar 

  85. European Environment Agency. 2001. Late lessons from early warnings: the precautionary principle 1896-2000. Environmental issue report No 22. European Environment Agency, Copenhagen, Denmark.

    Google Scholar 

  86. Anonymous. 2006. Safety catch. Risk assessment is a useful environmental tool, but not if it is used as a cover for a deregulatory agenda. Nature442:223-224.

    Google Scholar 

  87. Macilwain C. 2006. Safe and sound? Nature442:242-243.

    Article  CAS  PubMed  Google Scholar 

  88. Hart JW, Jensen NJ. 1990. The myth of the final hazard assessment. Regul Toxicol Pharmacol11:123-131.

    Article  CAS  PubMed  Google Scholar 

  89. National Research Council. 2006. Human Bio monitoring for Environmental Toxicants. National Academic Press, Washington, DC.

    Google Scholar 

  90. Paustenbach D, Galbraith D. 2006. Biomonitoring and biomarkers: exposure assessment will never be the same. Environ Health Perspect 114:1143-1149.

    Article  CAS  PubMed  Google Scholar 

  91. Taskforce on a Canadian information system for the environment. 2002. Informing environmental decisions. Interim report. Environment Canada. Ottawa, Canada.

    Google Scholar 

  92. Cairns Jr J, Dickson KL, Maki AW. 1987. Estimating Hazards of Chemicals to Aquatic Life. STP 675. American Society for Testing and Materials, Philadelphia, PA.

    Google Scholar 

  93. Hansen BG, van Haelst AG, van Leeuwen K, van der Zandt P. 1999. Priority setting for existing chemicals: the European Union risk assessment method. Environ Toxicol Chem 8:772-779.

    Article  Google Scholar 

  94. Bradbury S, Feijtel T, Van Leeuwen K. 2004. Meeting the scientific needs of ecological risk assessment in a regulatory context. Environ Sci Technol 38/23:63a-470a.

    Article  Google Scholar 

  95. Chapman A. 2006. Regulating chemicals. From risks to riskiness. Risk Analysis 26:603-616.

    Article  PubMed  Google Scholar 

  96. Power M, McCarty LS. 1998. A comparative analysis of environmental risk assessment/risk management frameworks. Env Sci Technol May:224A-231A.

    Google Scholar 

  97. European Commission. 2005. Opinion on the appropriateness of existing methodologies to assess the risks associated with engineered and adventitious products of nanotechnologies. Scientific Committee on Emerging and Newly Identified Health Risks (SCENIHR), Brussels, Belgium.

    Google Scholar 

  98. Organization for Economic Co-operation and Development. 2003. Description of selected key generic terms used in chemical hazard/risk assessment. Joint project with IPCS on the harmonization of hazard/risk assessment terminology. OECD Environment, Health and Safety Publications. Series on Testing and Assessment 44. OECD, Paris, France.

    Google Scholar 

  99. Christensen FM, Andersen O, Duijm NJ, Harremoes P. 2003. Risk terminology -a platform for common understanding and better communication. J Hazardous Materials A103:181-203.

    Article  CAS  Google Scholar 

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  1. C.J. Van Leeuwen
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Editors and Affiliations

  1. European Commission, Joint Research Centre, Ispra, Italy

    C.J. van Leeuwen

  2. Netherlands Organization for Applied Scientific Research TNO, Zeist

    C.J. van Leeuwen

  3. National Institute for Public Health and the Environment, Bilthoven, The Netherlands

    T.G. Vermeire

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Leeuwen, C.V. (2007). General Introduction. In: Leeuwen, C.v., Vermeire, T. (eds) Risk Assessment of Chemicals. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-6102-8_1

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