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Endocrine Hypertension: A Practical Approach

  • Chapter
Hypertension: from basic research to clinical practice

Part of the book series: Advances in Experimental Medicine and Biology ((AIM,volume 956))

Abstract

Elevated blood pressure resulting from few endocrine disorders (endocrine hypertension) accounts for a high proportion of cases of secondary hypertension. Although some features may be suggestive, many cases of endocrine hypertension remain silent until worked up for the disease. A majority of cases result from primary aldosteronism. Other conditions that can cause endocrine hypertension are: congenital adrenal hyperplasia, Liddle syndrome, pheochromocytomas, Cushing’s syndrome, acromegaly, thyroid diseases, primary hyperparathyroidism and iatrogenic hormone manipulation. Early identification and treatment of the cause of endocrine hypertension may help to reduce morbidity and mortality related to these disorders. This article gives a comprehensive and practical approach to the diagnosis and management of endocrine hypertension.

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References

  • Agarwal G, Nanda G, Kapoor A, Singh KR, Chand G, Mishra A et al (2013) Cardiovascular dysfunction in symptomatic primary hyperparathyroidism and its reversal after curative parathyroidectomy: results of a prospective case control study. Surgery 154:1394–1403

    Article  PubMed  Google Scholar 

  • Akkad AA, Halligan AW, Abrams K, al-Azzawi F (1997) Differing responses in blood pressure over 24 hours in normotensive women receiving oral or transdermal estrogen replacement therapy. Obstet Gynecol 89:97–103

    Article  CAS  PubMed  Google Scholar 

  • Alexandraki KI, Kaltsas GA, Isidori AM, Akker SA, Drake WM, Chew SL et al (2009) The prevalence and characteristic features of cyclicity and variability in Cushing’s disease. Eur J Endocrinol 160:1011–1018

    Article  CAS  PubMed  Google Scholar 

  • Anagnostis P, Athyros VG, Tziomalos K, Karagiannis A, Mikhailidis DP (2009) The pathogenetic role of cortisol in the metabolic syndrome: a hypothesis. J Clin Endocrinol Metab 94:2692–2701

    Article  CAS  PubMed  Google Scholar 

  • Bertagna X, Pivonello R, Fleseriu M, Zhang Y, Robinson P, Taylor A et al (2014) LCI699, a potent 11β-hydroxylase inhibitor, normalizes urinary cortisol in patients with Cushing’s disease: results from a ulticentre, proof-of-concept study. J Clin Endocrinol Metab 99:1375–1383

    Article  CAS  PubMed  Google Scholar 

  • Boulkroun S, Fernandes-Rosa FL, Zennaro MC (2015) Molecular and cellular mechanisms of aldosterone producing adenoma development. Front Endocrinol (Lausanne) 6:95

    Google Scholar 

  • Broulik PD, Brouliková A, Adámek S, Libanský P, Tvrdoň J, Broulikova K et al (2011) Improvement of hypertension after parathyroidectomy of patients suffering from primary hyperparathyroidism. Int J Endocrinol 2011:309068

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Capatina C, Wass JA (2015) 60 years of neuroendocrinology: acromegaly. J Endocrinol 226:T141–T160

    Article  CAS  PubMed  Google Scholar 

  • Chen H, Xi Q, Zhang H, Song B, Liu X, Mao X et al (2012) Investigation of thyroid function and blood pressure in school-aged subjects without overt thyroid disease. Endocrine 41:122–129

    Article  CAS  PubMed  Google Scholar 

  • Clayton RN, Raskauskiene D, Reulen RC, Jones PW (2011) Mortality and morbidity in Cushing’s disease over 50 years in Stoke-on-Trent, UK: audit and meta-analysis of literature. J Clin Endocrinol Metab 96:632–642

    Article  CAS  PubMed  Google Scholar 

  • Colao A, Petersenn S, Newell-Price J, Findling JW, Gu F, Maldonado M et al (2012) A 12-month phase 3 study of pasireotide in Cushing’s disease. New Engl J Med 366:914–924

    Article  CAS  PubMed  Google Scholar 

  • Colao A, Bronstein MD, Freda P et al (2014) Pasireotide versus octreotide in acromegaly: a head-to-head superiority study. J Clin Endocrinol Metab 99:791–799

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Correa R, Salpea P, Stratakis C (2015) Carney complex: an update. Eur J Endocrinol 173:M85–M97

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Daniel E, Newell-Price JD (2015) Therapy of endocrine disease: steroidogenesis enzyme inhibitors in Cushing’s syndrome. Eur J Endocrinol 172:R263–R280

    Article  CAS  PubMed  Google Scholar 

  • Daniel E, Aylwin S, Mustafa O, Ball S, Munir A, Boelaert K et al (2015) Effectiveness of metyrapone in treating Cushing’s Syndrome: a retrospective multicenter study in 195 patients. J Clin Endocrinol Metab 100:4146–4154

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • De Leo M, Pivonello R, Auriemma RS, Cozzolino A, Vitale P, Simeoli C et al (2010) Cardiovascular disease in Cushing’s syndrome: heart versus vasculature. Neuroendocrinology 92:50–54

    Article  PubMed  Google Scholar 

  • Desai AS, Chutkow WA, Edelman E, Economy KE, Dec GW Jr (2009) Clinical problem-solving. A crisis in late pregnancy. N Engl J Med 361:2271–2277

    Article  CAS  PubMed  Google Scholar 

  • Di Dalmazi G, Pasquali R, Beuschlein F, Reincke M (2015) Subclinical hypercortisolism: a state, a syndrome, or a disease? Eur J Endocrinol 173:M61–M71

    Article  PubMed  Google Scholar 

  • Donadille B, Groussin L, Waintrop C, Abbas H, Tenenbaum F, Dugue MA (2010) Management of Cushing’s syndrome due to ectopic adrenocorticotropin secretion with 1, ortho-1, para’-dichloro-diphenyl-dichloro-ethane: findings in 23 patients from a single center. J Clin Endocrinol Metab 95:537–544

    Article  CAS  PubMed  Google Scholar 

  • Eisenhofer G, Goldstein DS, Walther MM et al (2003) Biochemical diagnosis of pheochromocytoma: how to distinguish true- from false-positive test results. J Clin Endocrinol Metab 88:2656–2666

    Article  CAS  PubMed  Google Scholar 

  • European Medicines Agency (2016) Ketoconazole HRA recommended for approval in Cushing’s syndrome. Available from URL: http://www.ema.europa.eu/ema/index.jsp?curl = pages/news_and_events/news/2014/09/news_detail_002174.jsp&mid = WC0b01ac058004d5c1. Assessed 02 Feb 2016

  • Fatourechi V (2009) Subclinical hypothyroidism: an update for primary care physicians. Mayo Clin Proc 84:65–71

    Article  PubMed  PubMed Central  Google Scholar 

  • Feelders RA, de Bruin C, Pereira AM, Romijn JA, Netea-Maier RT, Hermus AR et al (2010) Pasireotide alone or with cabergoline and ketoconazole in Cushing’s disease. New Engl J Med 362:1846–1848

    Article  CAS  PubMed  Google Scholar 

  • Ferraù F, Korbonits M (2015) Metabolic comorbidities in Cushing’s syndrome. Eur J Endocrinol 173:M133–M157

    Article  PubMed  Google Scholar 

  • Fleseriu M, Biller BM, Findling JW, Molitch ME, Schteingart DE, Gross C et al (2012) Mifepristone, a glucocorticoid receptor antagonist, produces clinical and metabolic benefits in patients with Cushing’s syndrome. J Clin Endocrinol Metab 97:2039–2049

    Article  CAS  PubMed  Google Scholar 

  • Florez JC, Shepard JA, Kradin RL (2013) Case records of the Massachusetts General Hospital. Case 17–2013. A 56-year-old woman with poorly controlled diabetes mellitus and fatigue. N Engl J Med 368:2126–2136

    Article  CAS  PubMed  Google Scholar 

  • Funder JW, Carey RM, Fardella C, Gomez-Sanchez CE, Mantero F, Stowasser M et al (2008) Case detection, diagnosis, and treatment of patients with primary aldosteronism: an endocrine society clinical practice guideline. J Clin Endocrinol Metab 93:3266–3281

    Article  CAS  PubMed  Google Scholar 

  • Geller DS, Farhi A, Pinkerton N, Fradley M, Moritz M, Spitzer A et al (2000) Activating mineralocorticoid receptor mutation in hypertension exacerbated by pregnancy. Science 289(5476):119–123

    Article  CAS  PubMed  Google Scholar 

  • Graversen D, Vestergaard P, Stochholm K, Gravholt CH, Jørgensen JO (2012) Mortality in Cushing’s syndrome: a systematic review and meta-analysis. Eur J Intern Med 23:278–282

    Article  CAS  PubMed  Google Scholar 

  • Hagström E, Ahlström T, Ärnlöv J, Larsson A, Melhus H, Hellman P et al (2015) Parathyroid hormone and calcium are independently associated with subclinical vascular disease in a community-based cohort. Atherosclerosis 238:420–426

    Article  PubMed  Google Scholar 

  • Hannemann A, Wallaschofski H (2012) Prevalence of primary aldosteronism in patient’s cohorts and in population-based studies – a review of the current literature. Horm Metab Res 44:157–162

    Article  CAS  PubMed  Google Scholar 

  • Helfand M, U.S. Preventive Services Task Force (2004) Screening for subclinical thyroid dysfunction in nonpregnant adults: a summary of the evidence for the U.S. Preventive Services Task Force. Ann Intern Med 140:128–141

    Article  PubMed  Google Scholar 

  • Hollowell JG, Staehling NW, Flanders WD et al (2002) Serum TSH, T(4), and thyroid antibodies in the United States population (1988 to 1994): National Health and Nutrition Examination Survey (NHANES III). J Clin Endocrinol Metab 87:489–499

    Article  CAS  PubMed  Google Scholar 

  • Ittermann T, Thamm M, Wallaschofski H, Rettig R, Völzke H (2012) Serum thyroid-stimulating hormone levels are associated with blood pressure in children and adolescents. J Clin Endocrinol Metab 97:828–834

    Article  CAS  PubMed  Google Scholar 

  • Janjgava S, Zerekidze T, Uchava L, Giorgadze E, Asatiani K (2014) Influence of testosterone replacement therapy on metabolic disorders in male patients with type 2 diabetes mellitus and androgen deficiency. Eur J Med Res 19:56

    Article  PubMed  PubMed Central  Google Scholar 

  • Kasperlik-Zaluska AA, Roslonowska E, Slowinska-Srzednicka J, Otto M, Cichocki A, Cwikla J et al (2006) 1,111 patients with adrenal incidentalomas observed at a single endocrinological center: incidence of chromaffin tumors. Ann N Y Acad Sci 1073:38–46

    Article  CAS  PubMed  Google Scholar 

  • Katznelson L (2010) Approach to the patient with persistent acromegaly after pituitary surgery. J Clin Endocrinol Metab 95:4114–4123

    Article  CAS  PubMed  Google Scholar 

  • Katznelson L, Laws ER Jr, Melmed S, Molitch ME, Murad MH, Utz A et al (2014) Acromegaly: an endocrine society clinical practice guideline. J Clin Endocrinol Metab 99:3933–3951

    Article  CAS  PubMed  Google Scholar 

  • Kienitz T, Quinkler M (2008) Testosterone and blood pressure regulation. Kidney Blood Press Res 31:71–79

    Article  CAS  PubMed  Google Scholar 

  • Kiernan CM, Solórzano CC (2016) Pheochromocytoma and paraganglioma: Diagnosis, genetics, and treatment. Surg Oncol Clin N Am 25:119–138

    Article  PubMed  Google Scholar 

  • Kim SM, Rhee JH (2015) A case of 17 alpha-hydroxylase deficiency. Clin Exp Reprod Med 42:72–76

    Article  PubMed  PubMed Central  Google Scholar 

  • Klein I, Ojamaa K (2001) Thyroid hormone and the cardiovascular system. N Engl J Med 344:501–509

    Article  CAS  PubMed  Google Scholar 

  • Korah HE, Scholl UI (2015) An update on familial hyperaldosteronism. Horm Metab Res 47(13):941–946. [Epub ahead of print]

    Article  CAS  PubMed  Google Scholar 

  • Koulouri O, Steuwe A, Gillett D, Hoole AC, Powlson AS, Donnelly NA et al (2015) A role for 11C-methionine PET imaging in ACTH-dependent Cushing’s syndrome. Eur J Endocrinol 173:M107–M120

    Article  CAS  PubMed  Google Scholar 

  • Lenders JW, Duh QY, Eisenhofer G, Gimenez-Roqueplo AP, Grebe SK, Murad MH et al (2014) Pheochromocytoma and paraganglioma: an endocrine society clinical practice guideline. J Clin Endocrinol Metab 99:1915–1942

    Article  CAS  PubMed  Google Scholar 

  • Letizia C, Ferrari P, Cotesta D, Caliumi C, Cianci R, Cerci S et al (2005) Ambulatory Monitoring of Blood Pressure (AMBP) in patients with primary hyperparathyroidism. J Hum Hypertens 19:901–906

    Article  CAS  PubMed  Google Scholar 

  • Lim V, Guo Q, Grant CS, Thompson GB, Richards ML, Farley DR et al (2014) Accuracy of adrenal imaging and adrenal venous sampling in predicting surgical cure of primary aldosteronism. J Clin Endocrinol Metab 99:2712–2719

    Article  CAS  PubMed  Google Scholar 

  • Lind L, Jacobsson S, Palmer M, Lithell H, Wengle B, Ljunghall S (1991) Cardiovascular risk factors in primary hyperparathyroidism: a 15-year follow-up of operated and unoperated cases. J Intern Med 230:29–35

    Article  CAS  PubMed  Google Scholar 

  • Lundgren E, Rastad J, Thrufjell E, Akerstrom G, Ljunghall S (1997) Population-based screening for primary hyperparathyroidism with serum calcium and parathyroid hormone values in menopausal women. Surgery 121:287–294

    Article  CAS  PubMed  Google Scholar 

  • Manolopoulou J, Fischer E, Dietz A, Diederich S, Holmes D, Junnila R et al (2015) Clinical validation for the aldosterone-to-renin ratio and aldosterone suppression testing using simultaneous fully automated chemiluminescence immunoassays. J Hypertens 33:2500–2511

    Article  CAS  PubMed  Google Scholar 

  • Marcocci C, Cetani F (2011) Clinical practice. Primary hyperparathyroidism. N Engl J Med 365:2389–2397

    Article  CAS  PubMed  Google Scholar 

  • Melcescu E, Phillips J, Moll G, Subauste JS, Koch CA (2012) 11Beta-hydroxylase deficiency and other syndromes of mineralocorticoid excess as a rare cause of endocrine hypertension. Horm Metab Res 44:867–878

    Article  CAS  PubMed  Google Scholar 

  • Melmed S (2009) Acromegaly pathogenesis and treatment. J Clin Invest 119:3189–3202

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Mestron A, Webb SM, Astorga R et al (2004) Epidemiology, clinical characteristics, outcome, morbidity and mortality in acromegaly based on the Spanish Acromegaly Registry (Registro Espanol de Acromegalia, REA). Eur J Endocrinol 151:439–446

    Article  CAS  PubMed  Google Scholar 

  • Mihailidou AS, Le Loan TY, Mardini M, Funder JW (2009) Glucocorticoids activate cardiac mineralocorticoid receptors during experimental myocardial infarction. Hypertension 54:1306–1312

    Article  CAS  PubMed  Google Scholar 

  • Miller WL, Auchus RJ (2011) The molecular biology, biochemistry, and physiology of human steroidogenesis and its disorders. Endocr Rev 32:81–151

    Article  CAS  PubMed  Google Scholar 

  • Mulatero P, Stowasser M, Loh KC, Fardella CE, Gordon RD, Mosso L et al (2004) Increased diagnosis of primary aldosteronism, including surgically correctable forms, in centers from five continents. J Clin Endocrinol Metab 89:1045–1050

    Article  CAS  PubMed  Google Scholar 

  • Mussa A, Camilla R, Monticone S, Porta F, Tessaris D, Verna F et al (2012) Polyuric-polydipsic syndrome in a pediatric case of non-glucocorticoid remediable familial hyperaldosteronism. Endocr J 59:497–502

    Article  CAS  PubMed  Google Scholar 

  • Muth A, Ragnarsson O, Johannsson G, Wängberg B (2015) Systematic review of surgery and outcomes in patients with primary aldosteronism. Br J Surg 102:307–317

    Article  CAS  PubMed  Google Scholar 

  • Nainby-Luxmoore JC, Langford HG, Nelson NC, Watson RL, Barnes TY (1982) A case-comparison study of hypertension and hyperparathyroidism. J Clin Endocrinol Metab 55:303–306

    Article  CAS  PubMed  Google Scholar 

  • New MI, Geller DS, Fallo F, Wilson RC (2005) Monogenic low renin hypertension. Trends Endocrinol Metab 16:92–97

    Article  CAS  PubMed  Google Scholar 

  • Nieman LK (2002) Medical therapy of Cushing’s disease. Pituitary 5:77–82

    Article  CAS  PubMed  Google Scholar 

  • Nieman LK (2015) Cushing’s syndrome: update on signs, symptoms and biochemical screening. Eur J Endocrinol 173:M33–M38

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Nieman LK, Biller BM, Findling JW, Newell-Price J, Savage MO, Stewart PM et al (2008) The diagnosis of Cushing’s syndrome: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab 93:1526–1540

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Nieman LK, Biller BM, Findling JW, Murad MH, Newell-Price J, Savage MO et al (2015) Treatment of Cushing’s syndrome: An Endocrine Society clinical practice guideline. J Clin Endocrinol Metab 100:2807–2831

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Pappachan JM, Raskauskiene D, Sriraman R, Edavalath M, Hanna FW (2014) Diagnosis and management of pheochromocytoma: a practical guide to clinicians. Curr Hypertens Rep 16:442

    Article  PubMed  Google Scholar 

  • Parenti G, Zampetti B, Rapizzi E et al (2012) Updated and new perspectives on diagnosis, prognosis, and therapy of malignant pheochromocytoma/paraganglioma. J Oncol 2012:872713

    Article  PubMed  PubMed Central  Google Scholar 

  • Pecori Giraldi F, Ambrogio AG, Andrioli M, Sanguin F, Karamouzis I, Corsello SM et al (2012) Potential role for retinoic acid in patients with Cushing’s disease. J Clin Endocrinol Metab 97:3577–3583

    Article  PubMed  Google Scholar 

  • Piaditis G, Markou A, Papanastasiou L, Androulakis II, Kaltsas G (2015) Progress in aldosteronism: a review of the prevalence of primary aldosteronism in pre-hypertension and hypertension. Eur J Endocrinol 172:R191–R203

    Article  CAS  PubMed  Google Scholar 

  • Preston RA (2009) Comparative effects of conventional vs. novel hormone replacement therapy on blood pressure in postmenopausal women. Climacteric 12(Suppl 1):66–70

    Article  CAS  PubMed  Google Scholar 

  • Proven A, Gabriel SE, Orces C, O’Fallon WM, Hunder GG (2003) Glucocorticoid therapy in giant cell arteritis: duration and adverse outcomes. Arthritis Rheum 49:703–708

    Article  CAS  PubMed  Google Scholar 

  • Puig-Domingo M, Resmini E, Gomez-Anson B et al (2010) Magnetic resonance imaging as a predictor of response to somatostatin analogues in acromegaly after surgical failure. J Clin Endocrinol Metab 95:4973–4978

    Article  CAS  PubMed  Google Scholar 

  • Rapado A (1986) Arterial hypertension and primary hyperparathyroidism. Incidence and follow-up after parathyroidectomy. Am J Nephrol 6(Suppl 1):49–50

    Article  PubMed  Google Scholar 

  • Reincke M (2015) Improving outcome in Cushing’s syndrome. Eur J Endocrinol 173:E3–E5

    Article  CAS  PubMed  Google Scholar 

  • Reincke M, Ritzel K, Oßwald A, Berr C, Stalla G, Hallfeldt K, Reisch N et al (2015) A critical reappraisal of bilateral adrenalectomy for ACTH-dependent Cushing’s syndrome. Eur J Endocrinol 173:M23–M32

    Article  CAS  PubMed  Google Scholar 

  • Rimoldi SF, Scherrer U, Messerli FH (2014) Secondary arterial hypertension: when, who, and how to screen? Eur Heart J 35:1245–1254

    Article  PubMed  Google Scholar 

  • Ringe JD (1984) Reversible hypertension in primary hyperparathyroidism—pre- and postoperative blood pressure in 75 cases. Klin Wochenschr 62:465–469

    Article  CAS  PubMed  Google Scholar 

  • Rizzoni D, Porteri E, De Ciuceis C, Rodella LF, Paiardi S, Rizzardi N et al (2009) Hypertrophic ulticentre of subcutaneous small resistance arteries in patients with Cushing’s syndrome. J Clin Endocrinol Metab 94:5010–5018

    Article  CAS  PubMed  Google Scholar 

  • Rossi GP, Auchus RJ, Brown M, Lenders JW, Naruse M, Plouin PF et al (2014) An expert consensus statement on use of adrenal vein sampling for the subtyping of primary aldosteronism. Hypertension 63:151–160

    Article  CAS  PubMed  Google Scholar 

  • Sahakitrungruang T (2015) Clinical and molecular review of atypical congenital adrenal hyperplasia. Ann Pediatr Endocrinol Metab 20:1–7

    Article  PubMed  PubMed Central  Google Scholar 

  • Silverberg SJ, Lewiecki EM, Mosekilde L, Peacock M, Rubin MR et al (2009) Presentation of asymptomatic primary hyperparathyroidism: proceedings of the third international workshop. J Clin Endocrinol Metab 94:351–365

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Speiser PW (2015) Congenital adrenal hyperplasia. F1000Res; 4(F1000 Faculty Rev): 601.

    Google Scholar 

  • Thomas RM, Ruel E, Shantavasinkul PC, Corsino L (2015) Endocrine hypertension: an overview on the current etiopathogenesis and management options. World J Hypertens 5:14–27

    Article  PubMed  PubMed Central  Google Scholar 

  • Tsirlin A, Oo Y, Sharma R, Kansara A, Gliwa A, Banerji MA (2014) Pheochromocytoma: a review. Maturitas 77:229–238

    Article  CAS  PubMed  Google Scholar 

  • van der Lely AJ, Biller BM, Brue T et al (2012) Long-term safety of pegvisomant in patients with acromegaly: comprehensive review of 1288 subjects in ACROSTUDY. J Clin Endocrinol Metab 97:1589–1597

    Article  PubMed  Google Scholar 

  • Velasco A, Vongpatanasin W (2014) The evaluation and treatment of endocrine forms of hypertension. Curr Cardiol Rep 16:528

    Article  PubMed  Google Scholar 

  • Wang LP, Yang KQ, Jiang XJ, Wu HY, Zhang HM, Zou YB et al (2015) Prevalence of Liddle syndrome among young hypertension patients of undetermined cause in a Chinese population. J Clin Hypertens (Greenwich) 17:902–907

    Article  CAS  Google Scholar 

  • Weber MA, Schiffrin EL, White WB, Mann S, Lindholm LH, Kenerson JG et al (2014) Clinical practice guidelines for the management of hypertension in the community: a statement by the American Society of Hypertension and the International Society of Hypertension. J Clin Hypertens (Greenwich) 16:14–26

    Article  Google Scholar 

  • Wermers RA, Khosla S, Atkinson EJ, Achenbach SJ, Oberg AL, Grant CS et al (2006) Incidence of primary hyperparathyroidism in Rochester, Minnesota, 1993–2001: an update on the changing epidemiology of the disease. J Bone Miner Res 21:171–177

    Article  PubMed  Google Scholar 

  • World Health Organization. Obesity and overweight. 2015. [assessed 30 November 2015]. Available from URL: http://apps.who.int/iris/bitstream/10665/79059/1/WHO_DCO_WHD_2013.2_eng.pdf?ua=1

  • Young WF (2007) Primary aldosteronism: renaissance of a syndrome. Clin Endocrinol (Oxf) 66:607–618

    Article  CAS  Google Scholar 

  • Young WF Jr (2015) Endocrine hypertension. In: Melmed S, Polonsky KS, Larsen PR, Kronenberg HM (eds) Williams textbook of endocrinology, 13th edn. Elsevier, New York, pp 556–588

    Google Scholar 

  • Zennaro MC, Rickard AJ, Boulkroun S (2013) Genetics of mineralocorticoid excess: an update for clinicians. Eur J Endocrinol 169:R15–R25

    Article  CAS  PubMed  Google Scholar 

  • Zennaro MC, Boulkroun S, Fernandes-Rosa F (2015a) An update on novel mechanisms of primary aldosteronism. J Endocrinol 224:R63–R77

    Article  CAS  PubMed  Google Scholar 

  • Zennaro MC, Boulkroun S, Fernandes-Rosa F (2015b) Inherited forms of mineralocorticoid hypertension. Best Pract Res Clin Endocrinol Metab 29:633–645

    Article  CAS  PubMed  Google Scholar 

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  1. Department of Endocrinology & Diabetes, New Cross Hospital, The Royal Wolverhampton Hospital NHS Trust, Wolverhampton, WV10 0QP, UK

    Joseph M. Pappachan & Harit N. Buch

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Correspondence to Joseph M. Pappachan .

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  1. Department of Clinical Science and Education Södersjukhuset, Karolinska Institutet, Stockholm, Sweden

    Md. Shahidul Islam

  2. Department of Internal Medicine and Emergency Medicine, Uppsala University Hospital, Uppsala, Sweden

    Md. Shahidul Islam

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Pappachan, J.M., Buch, H.N. (2016). Endocrine Hypertension: A Practical Approach. In: Islam, M.S. (eds) Hypertension: from basic research to clinical practice. Advances in Experimental Medicine and Biology(), vol 956. Springer, Cham. https://doi.org/10.1007/5584_2016_26

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  • DOI: https://doi.org/10.1007/5584_2016_26

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