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An Overview of European Clinical Trials of Accelerated Partial Breast Irradiation

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Accelerated Partial Breast Irradiation

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References

  1. Cionini L, Marzano S, Pacini P, et al (1995) Iridium implant of the surgical bed as the sole radiotherapeutic treatment after conservative surgery for breast cancer (Abstract). Radiother Oncol 35[Suppl l]:S1

    Google Scholar 

  2. Clarke DH, Vicini F, Jacobs H, et al (1994) High dose rate brachytherapy for breast cancer. In: Nag S (ed) High dose rate brachytherapy: a textbook. Futura Publishing Company, New York, pp 321–329

    Google Scholar 

  3. Clark RM, Whelan T, Levine R (1996) Randomized clinical trial of breast irradiation following lumpectomy and axillary dissection for node-negative breast cancer: an update. J Natl Cancer Inst 88:1659–1654

    PubMed  CAS  Google Scholar 

  4. Edmundson GK, Vicini F, Chen P, et al (2002) Dosimetric characteristics of the MammoSite® RTS, a new breast brachytherapy applicator. Int J Radiat Oncol Biol Phys 4:1132–1139

    Article  Google Scholar 

  5. Fentiman IS, Poole C, Tong PJ, et al (1991) Iridium implant treatment without external radiotherapy for operable breast cancer: a pilot study. Eur J Cancer 27:447–450

    Article  PubMed  CAS  Google Scholar 

  6. Fentiman IS, Poole C, Tong D, et al (1996) Inadequacy of iridium implant as a sole radiation treatment for operable breast cancer. Eur J Cancer 32A:608–611

    Article  PubMed  CAS  Google Scholar 

  7. Fentiman IS, Deshmane V, Tong D, et al (2004) Caesium137 implant as sole radiation therapy for operable breast cancer: a phase II trial. Radiother Oncol 71:281–285

    Article  PubMed  CAS  Google Scholar 

  8. Harper J, Jenerette JM, Vanek KN, et al (2005) Acute complications of MammoSite® brachytherapy: a single institution’s initial clinical experience. Int J Radiat Oncol Biol Phys 61:169–174

    Article  PubMed  Google Scholar 

  9. Jacobson JA, Danforth DN, Cowan KH (1995) Ten-year results of a comparison of conservation with mastectomy in the treatment of stage I and II breast cancer. N Engl J Med 332:907–911

    Article  PubMed  CAS  Google Scholar 

  10. Johansson B, Karlsson L, Liljegren G, et al (2002) PDR brachytherapy as the sole adjuvant radiotherapy after breast conserving surgery of T1-2 breast cancer (abstract). Program and Abstracts, 10th Nucletron International Brachytherapy Conference, Madrid, p 127

    Google Scholar 

  11. Lövey K, Nemeskéri C, Mayer A (1994) Analysis of local recurrences developed after conservative surgery of breast cancer (in Hungarian). Magyar Onkológia 38:179–183

    Google Scholar 

  12. Magee B, Swindell R, Harris M, et al (1996) Prognostic factors for breast recurrence after conservative breast surgery and radiotherapy: results of a randomised trial. Radiother Oncol 39:223–227

    Article  PubMed  CAS  Google Scholar 

  13. Mayer A, Nemeskéri C (1993) Forms of radiotherapy complementing operations of reduced radicality for early cancer of the breast (prospective clinical study) (in Hungarian). Magyar Sebészet 46:65–68

    Google Scholar 

  14. Niehoff P, Kovacs G, Polgar C, et al (2003) Feasibility of a new applicator system for interstitial brachtherapy of breast cancer. Radiother Oncol 67(Suppl. 1):S13

    Google Scholar 

  15. Ott OJ, Pötter R, Hammer J, et al (2004) Accelerated partial breast irradiation with iridium-192 multicatheter PDR/HDR brachytherapy. Preliminary results of the German-Austrian multicenter trial. Strahlenther Onkol 180:642–649

    Article  PubMed  Google Scholar 

  16. Ott OJ, Pötter R, Hildebrandt G, et al (2005a) Partial breast irradiation for early breast cancer: 3-year results of the German-Austrian phase II trial. Rofo 177:962–967

    PubMed  CAS  Google Scholar 

  17. Ott OJ, Schulz-Wendtland R, Uter W, et al (2005b) Fat necrosis after breast conserving surgery and interstitial brachytherapy and/or external beam irradiation in women with breast cancer. Strahlenther Onkol 181:638–644

    Article  PubMed  Google Scholar 

  18. Pass H, Vicini FA, Kestin LL, et al (2004) Changes in management techniques and patterns of disease recurrence over time in patients with breast carcinoma treated with breast-conserving therapy at a single institution. Cancer 101:713–720

    Article  PubMed  Google Scholar 

  19. Polgár C, Major T, Somogyi A, et al (2000) CT-image-based conformal brachytherapy of breast cancer. The significance of semi 3-D and 3-D treatment planning. Strahlenther Onkol 176:118–124

    Article  PubMed  Google Scholar 

  20. Polgár C, Fodor J, Major T, et al (2002a) Radiotherapy confined to the tumor bed following breast conserving surgery: current status, controversies, and future prospects. Strahlenther Onkol 178:597–606

    Article  PubMed  Google Scholar 

  21. Polgár C, Sulyok Z, Fodor J, et al (2002b) Sole brachytherapy of the tumor bed after conservative surgery for T1 breast cancer: five-year results of a phase I-II study and initial findings of a randomized phase III trial. J Surg Oncol 80:121–128

    Article  PubMed  Google Scholar 

  22. Polgár C, Major T, Fodor J, et al (2004a) HDR brachytherapy alone versus whole breast radiotherapy with or without tumor bed boost after breast conserving surgery: seven-year results of a comparative study. Int J Radiat Oncol Biol Phys 60:1173–1181

    Article  PubMed  Google Scholar 

  23. Polgár C, Major T, Strnad V, et al (2004b) What can we conclude from the results of an out-of-date breast-brachytherapy study? Int J Radiat Oncol Biol Phys 60:342–343

    Article  PubMed  Google Scholar 

  24. Polgár C, Strnad V, Major T (2005) Brachytherapy for partial breast irradiation: the European experience. Semin Radiat Oncol 15:116–122

    Article  PubMed  Google Scholar 

  25. Póti Z, Nemeskéri C, Fekésházy A, et al (2004) Partial breast irradiation with interstitial 60Co brachytherapy results in frequent grade 3 or 4 toxicity: evidence based on a 12-year follow-up of 70 patients. Int J Radiat Oncol Biol Phys 58:1022–1033

    Article  PubMed  Google Scholar 

  26. Ribeiro GG, Magee B, Swindell R, et al (1993) The Christie Hospital breast conservation trial: an update at 8 years from inception. Clin Oncol 5:278–283

    Article  CAS  Google Scholar 

  27. Samuel LM, Dewar JA, Preece PE, et al (1999) A pilot study of radical radiotherapy using a perioperative implant following wide local excision for carcinoma of the breast. Breast 8:95–97

    Article  Google Scholar 

  28. Shah NM, Tenenhoz T, Arthur D, et al (2004) MammoSite® and interstitial brachytherapy for accelerated partial breast irradiation: factors that affect toxicity and cosmesis. Cancer 101:727–734

    Article  PubMed  Google Scholar 

  29. Strnad V, Ott OJ, Pötter R, et al (2004) Interstitial brachytherapy alone after breast conserving surgery: interim results of a German-Austrian multicenter phase II trial. Brachytherapy 3:115–119

    Article  PubMed  Google Scholar 

  30. Turreson I (1990) Individual variation and dose dependency in the progression rate of skin telangiectasia. Int J Radiat Oncol Biol Phys 19:1569–1574

    Google Scholar 

  31. Van Dongen JA, Bartelink H, Fentiman IS (1992) Randomized clinical trial to assess the value of breast-conserving therapy in stage I and II breast cancer, EORTC 10801 Trial. J Natl Cancer Inst Monogr 11:15–18

    PubMed  Google Scholar 

  32. Van Limbergen E, van den Bogaert W, van der Schueren E, et al (1987) Tumor excision and radiotherapy as primary treatment of breast cancer. Analysis of patient and treatment parameters and local control. Radiother Oncol 8:1–9

    PubMed  Google Scholar 

  33. Van Limbergen E, Rijnders A, van der Schueren E, et al (1989) Cosmetic evaluation of breast conserving treatment for mammary cancer. II. A quantitative analysis of the influence of radiation dose, fractionation schedules and surgical treatment techniques on cosmetic results after tumor excision and radiotherapy. Radiother Oncol 16:253–267

    Article  PubMed  Google Scholar 

  34. Van Limbergen E, Briot E, Drijkoningen M (1990) The source-skin distance measuring bridge: a method to avoid radiation telangiectasia in the skin after interstitial therapy for breast cancer. Int J Radiat Oncol Biol Phys 18:1239–1244

    PubMed  Google Scholar 

  35. Vicini F, Edmundson G, Arthur D (2004a) In regard to Poti et al.: partial breast irradiation with interstitial (60)co brachytherapy results in frequent grade 3 or 4 toxicity: evidence based on a 12-year follow-up of 70 patients (Int J Radiat Oncol Biol Phys 2004;58:1022–1033). Int J Radiat Oncol Biol Phys 60:345

    Article  PubMed  Google Scholar 

  36. Vicini FA, Beitsch P, Quiet C, et al (2004b) First analysis of patient demographics and technical reproducibility by the American Society of Breast Surgeons (ASBS) MammoSite® breast brachytherapy registry trial in 801 patients treated with accelerated partial breast irradiation (APBI). Proceedings of the San Antonio Breast Cancer Symposium. 2004, San Antonio, TX, USA

    Google Scholar 

  37. Wazer DE, Lowther D, Boyle T, et al (2001) Clinically evident fat necrosis in women treated with high-dose-rate brachytherapy alone for early-stage breast cancer. Int J Radiat Oncol Biol Phys 50:107–111

    Article  PubMed  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Radiotherapy, National Institute of Oncology, Ráth Gy. u. 7-9., Budapest, 1122, Hungary

    Csaba Polgár & Tibor Major

  2. Department of Radiation Oncology, University Hospital Erlangen, Universitätsstr. 27, 91054, Erlangen, Germany

    Vratislav Strnad & Oliver J. Ott

  3. Department of Radiation Oncology, University Hospital Schleswig-Holstein, Campus Kiel, Arnold-Heller Str. 9, 24105, Kiel, Germany

    Peter Niehoff

Authors
  1. Csaba Polgár
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  2. Tibor Major
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  3. Vratislav Strnad
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  4. Peter Niehoff
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  5. Oliver J. Ott
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  6. György Kovács
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Editor information

Editors and Affiliations

  1. Department of Radiation Oncology, Tufts-New England Medical Center, Tufts University School of Medicine, 750 Washington Street, Boston, MA, 02111, USA

    David E. Wazer

  2. Department of Radiation Oncology, Virginia Commonwealth University Medical Center, Medical College Virginia Campus, 401 College St, Richmond, VA, 23298-0058, USA

    Douglas W. Arthur

  3. Department of Radiation Oncology, William Beaumont Hospital, 3577 W. Thirteen Mile Road, Ste. 210, Royal Oak, MI, 48073, USA

    Frank A. Vicini

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© 2006 Springer-Verlag Berlin Heidelberg

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Polgár, C., Major, T., Strnad, V., Niehoff, P., Ott, O.J., Kovács, G. (2006). An Overview of European Clinical Trials of Accelerated Partial Breast Irradiation. In: Wazer, D.E., Arthur, D.W., Vicini, F.A. (eds) Accelerated Partial Breast Irradiation. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-28203-3_16

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  • DOI: https://doi.org/10.1007/3-540-28203-3_16

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-28202-0

  • Online ISBN: 978-3-540-28203-7

  • eBook Packages: MedicineMedicine (R0)

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