Abstract
Stereotactic body radiation therapy (SBRT) consists of the delivery of precise, conformal, hypofractionated, and ablative therapy in a single or a small number of fractions to extracranial regions. Over the last decade, it is rapidly being integrated into mainstream radiation oncology practices. The indications for SBRT continue to grow, as does the technology associated with its delivery. This chapter presents a detailed overview of clinically relevant topics including patient selection and outcomes, and the technological aspects of planning and delivery of SBRT. The tumor streams covered in this chapter are lung, liver, spine, pancreas, renal cell carcinoma, adrenal, prostate, and head and neck. The chapter concludes by highlighting two novel areas, cardiac arrhythmias and pediatric oncology, in which the use of SBRT is emerging.
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References
Abelson JA, Murphy JD, Loo BW et al (2012) Esophageal tolerance to high-dose stereotactic ablative radiotherapy. Dis Esophagus 25(7):623–629
Abrams HL, Spiro R, Goldstein N (1950) Metastases in carcinoma; analysis of 1000 autopsied cases. Cancer 3(1):74–85
Abuodeh Y, Venkat P, Kim S et al (2016) Systematic review of case reports on the abscopal effect. Curr Probl Cancer 40(1):25–37
Ahmed KA, Barney BM, Macdonald OK et al (2013) Stereotactic body radiotherapy in the treatment of adrenal metastases. Am J Clin Oncol 36(5):509–513. doi:10.1097/COC.0b013e3182569189
Al-Omair A, Masucci L, Masson-Cote L et al (2013a) Surgical resection of epidural disease improves local control following postoperative spine stereotactic body radiotherapy. Neuro-Oncology 15(10):1413–1419
Al-Omair A, Smith R, Kiehl TR et al (2013b) Radiation-induced vertebral compression fracture following spine stereotactic radiosurgery: clinicopathological correlation: report of 2 cases. J Neurosurg Spine 18(5):430–435
Alongi F, Cozzi L, Arcangeli S, Iftode C et al (2013) Linac based SBRT for prostate cancer in 5 fractions with VMAT and flattening filter free beams: preliminary report of a phase II study. Radiat Oncol 8(1):171
Altoos B, Amini A, Yacoub M et al (2015) Local control rates of metastatic renal cell carcinoma (RCC) to thoracic, abdominal, and soft tissue lesions using stereotactic body radiotherapy (SBRT). Radiat Oncol 10(1):1
American Cancer Society (2016) Cancer Facts & Figures 2016. American Cancer Society, Atlanta
Amini A, Altoos B, Bourlon MT et al (2015) Local control rates of metastatic renal cell carcinoma (RCC) to the bone using stereotactic body radiation therapy: is RCC truly radioresistant? Pract Radiat Oncol 5(6):e589–e596
Ananthakrishnan A, Gogineni V, Saeian K (2006) Epidemiology of primary and secondary liver cancers. Semin Intervent Radiol 23(1):47–63
Andolino DL, Johnson CS, Maluccio M et al (2011) Stereotactic body radiotherapy for primary hepatocellular carcinoma. Int J Radiat Oncol Biol Phys 81(4):e447–e453
Arcangeli S, Strigari L, Gomellini S et al (2012) Updated results and patterns of failure in a randomized hypofractionation trial for high-risk prostate cancer. Int J Radiat Oncol Biol Phys 84(5):1172–1178
Ashworth AB, Senan S, Palma DA et al (2014) An individual patient data metaanalysis of outcomes and prognostic factors after treatment of oligometastatic non-small-cell lung cancer. Clin Lung Cancer 15(5):346–355
Bae SH, Kim MS, Cho CK et al (2012) Predictor of severe gastroduodenal toxicity after stereotactic body radiotherapy for abdominopelvic malignancies. Int J Radiat Oncol Biol Phys 84(4):e469–e474
Balagamwala EH, Angelov L, Koyfman SA et al (2012) Single-fraction stereotactic body radiotherapy for spinal metastases from renal cell carcinoma: clinical article. J Neurosurg 17(6):556–564
Barr A, Knox JJ, Wei AC et al (2016) Can stereotactic body radiotherapy effectively treat hepatocellular carcinoma? J Clin Oncol 34(5):404–408
Baumann P, Nyman J, Hoyer M et al (2009) Outcome in a prospective phase II trial of medically inoperable stage I non-small-cell lung cancer patients treated with stereotactic body radiotherapy. J Clin Oncol 27(20):3290–3296
Beddar AS, Briere TM, Balter P et al (2008) 4D-CT imaging with synchronized intravenous contrast injection to improve delineation of liver tumors for treatment planning. Radiother Oncol 87(3):445–448
Bekelman JE, Epstein AJ, Emanuel EJ (2013) Single- vs multiple-fraction radiotherapy for bone metastases from prostate cancer. JAMA 310(14):1501–1502
Benedict SH, Yenice KM, Followill D et al (2010) Stereotactic body radiation therapy: the report of AAPM task group 101. Med Phys 37(8):4078–4101
Berber B, Sanabria JR, Braun K et al (2013) Emerging role of stereotactic body radiotherapy in the treatment of pancreatic cancer. Expert Rev Anticancer Ther 13(4):481–487
Bezjak A, Paulus R, Gaspar L et al (2016) Primary study endpoint analysis for NRG oncology/RTOG 0813 trial of stereotactic body radiation therapy (SBRT) for centrally located non-small cell lung cancer (NSCLC). Int J Radiat Oncol Biol Phys 1(94):5–6
Bhatt N, Fogarty T, Maguire P (2016) Cardiac radiosurgery for the treatment of atrial fibrillation. World J Cardiovasc Dis 6(05):143
Bishop AJ, Tao R, Rebueno NC et al (2015) Outcomes for spine stereotactic body radiation therapy and an analysis of predictors of local recurrence. Int J Radiat Oncol Biol Phys 92(5):1016–1026
Blanck O, Bode F, Gebhard M et al (2014) Dose-escalation study for cardiac radiosurgery in a porcine model. Int J Radiat Oncol Biol Phys 89(3):590–598
Blanck O, Ipsen S, Chan MK et al (2016) Treatment planning considerations for robotic guided cardiac radiosurgery for atrial fibrillation. Cureus 8(7):e705
Bode F, Blanck O, Gebhard M et al (2016) Pulmonary vein isolation by radiosurgery: implications for non-invasive treatment of atrial fibrillation. Europace 17(12):1868
Boike TP, Lotan Y, Cho LC et al (2011) Phase I dose-escalation study of stereotactic body radiation therapy for low- and intermediate-risk prostate cancer. J Clin Oncol 29(15):2020–2026
Bolzicco G, Favretto MS, Scremin E et al (2010) Image-guided stereotactic body radiation therapy for clinically localized prostate cancer: preliminary clinical results. Technol Cancer Res Treat 9(5):473–477
Bral S, Gevaert T, Linthout N et al (2011) Prospective, risk-adapted strategy of stereotactic body radiotherapy for early-stage non-small-cell lung cancer: results of a phase II trial. Int J Radiat Oncol Biol Phys 80(5):1343–1349
Brenner DJ, Hall EJ (1999) Fractionation and protraction for radiotherapy of prostate carcinoma. Int J Radiat Oncol Biol Phys 43(5):1095–1101
Brock KK (2011) Imaging and image-guided radiation therapy in liver cancer. Semin Radiat Oncol 21(4):247–255
Brown JM, Carlson DJ, Brenner DJ (2014) The tumor radiobiology of SRS and SBRT: are more than the 5 Rs involved? Int J Radiat Oncol Biol Phys 88(2):254–262
Brunner TB, Nestle U, Grosu AL et al (2015) SBRT in pancreatic cancer: what is the therapeutic window? Radiother Oncol 114(1):109–116
Bujold A, Massey CA, Kim JJ et al (2013) Sequential phase I and II trials of stereotactic body radiotherapy for locally advanced hepatocellular carcinoma. J Clin Oncol 31(13):1631–1639
Calkins H, Kuck KH, Cappato R et al (2012) 2012 HRS/EHRA/ECAS expert consensus statement on catheter and surgical ablation of atrial fibrillation: recommendations for patient selection, procedural techniques, patient management and follow-up, definitions, endpoints, and research trial design. Europace 14(4):528
Camm J (2005) Atrial fibrillation—an end to the epidemic? Circulation 112(8):iii
Cardenes HR, Price TR, Perkins SM et al (2010) Phase I feasibility trial of stereotactic body radiation therapy for primary hepatocellular carcinoma. Clin Transl Oncol 12(3):218–225
Casamassima F, Livi L, Masciullo S et al (2012) Stereotactic radiotherapy for adrenal gland metastases: University of Florence experience. Int J Radiat Oncol Biol Phys 82(2):919–923
Cengiz M, Ozyigit G, Yazici G et al (2011) Salvage reirradiaton with stereotactic body radiotherapy for locally recurrent head-and-neck tumors. Int J Radiat Oncol Biol Phys 81(1):104–109
Chan MW, Thibault I, Atenafu EG et al (2016) Patterns of epidural progression following postoperative spine stereotactic body radiotherapy: implications for clinical target volume delineation. J Neurosurg Spine 24(4):652–659
Chang EL, Shiu AS, Mendel E et al (2007) Phase I/II study of stereotactic body radiotherapy for spinal metastasis and its pattern of failure. J Neurosurg Spine 7(2):151–160
Chang DT, Schellenberg D, Shen J et al (2009) Stereotactic radiotherapy for unresectable adenocarcinoma of the pancreas. Cancer 115(3):665–672
Chang J, Liu H, Zhang X et al (2011a) Four-dimensional CT-and on-board volumetric image-guided stereotactic ablative radiotherapy (SABR) for stage I non-small cell lung cancer. Int J Radiat Oncol Biol Phys 81(2):S623
Chang DT, Swaminath A, Kozak M et al (2011b) Stereotactic body radiotherapy for colorectal liver metastases: a pooled analysis. Cancer 117(17):4060–4069
Chang UK, Cho WI, Lee DH et al (2012) Stereotactic radiosurgery for primary and metastatic sarcomas involving the spine. J Neuro-Oncol 107(3):551–557
Chang JY, Li Q-Q, Xu Q-Y et al (2014a) Stereotactic ablative radiation therapy for centrally located early stage or isolated parenchymal recurrences of non-small cell lung cancer: how to fly in a “no fly zone”. Int J Radiat Oncol Biol Phys 88(5):1120–1128
Chang UK, Lee DH, Kim MS (2014b) Stereotactic radiosurgery for primary malignant spinal tumors. Neurol Res 36(6):597–606
Chang JY, Senan S, Paul MA et al (2015) Stereotactic ablative radiotherapy versus lobectomy for operable stage I non-small-cell lung cancer: a pooled analysis of two randomised trials. Lancet Oncol 16(6):630–637
Chang JH, Cheung P, Erler D et al (2016) Stereotactic ablative body radiotherapy for primary renal cell carcinoma in non-surgical candidates: initial clinical experience. Clin Oncol (R Coll Radiol) 28(9):109–114
Chao ST, Koyfman SA, Woody N et al (2012) Recursive partitioning analysis index is predictive for overall survival in patients undergoing spine stereotactic body radiation therapy for spinal metastases. Int J Radiat Oncol Biol Phys 82(5):1738–1743
Chen HH, Tsai ST, Wang MS et al (2006) Experience in fractionated stereotactic body radiation therapy boost for newly diagnosed nasopharyngeal carcinoma. Int J Radiat Oncol Biol Phys 66(5):1408–1414
Chiang A, Zeng L, Zhang L et al (2013) Pain flare is a common adverse event in steroid-naive patients after spine stereotactic body radiation therapy: a prospective clinical trial. Int J Radiat Oncol Biol Phys 86(4):638–642
Choi CY, Adler JR, Gibbs IC et al (2010) Stereotactic radiosurgery for treatment of spinal metastases recurring in close proximity to previously irradiated spinal cord. Int J Radiat Oncol Biol Phys 78(2):499–506
Chow E, Harris K, Fan G, Tsao M et al (2007) Palliative radiotherapy trials for bone metastases: a systematic review. J Clin Oncol 25(11):1423–1436
Chow E, van der Linden YM, Roos D et al (2014) Single versus multiple fractions of repeat radiation for painful bone metastases: a randomised, controlled, non-inferiority trial. Lancet Oncol 15(2):164–171
Chuang C, Sahgal A, Lee L et al (2007) Effects of residual target motion for image-tracked spine radiosurgery. Med Phys 34(11):4484–4490
Chuong MD, Springett GM, Freilich JM et al (2013) Stereotactic body radiation therapy for locally advanced and borderline resectable pancreatic cancer is effective and well tolerated. Int J Radiat Oncol Biol Phys 86(3):516–522
Corbin KS, Hellman S, Weichselbaum RR (2013) Extracranial oligometastases: a subset of metastases curable with stereotactic radiotherapy. J Clin Oncol 31(11):1384–1390
Correa RJ, Rodrigues GB, Chen H et al (2016) Stereotactic ablative radiotherapy (SABR) for large renal tumors: a retrospective case series evaluating clinical outcomes, toxicity, and technical considerations. Am J Clin Oncol. doi:10.1097/COC.0000000000000329
Cox BW, Spratt DE, Lovelock M et al (2012a) International spine radiosurgery consortium consensus guidelines for target volume definition in spinal stereotactic radiosurgery. Int J Radiat Oncol Biol Phys 83(5):e597–e605
Cox BW, Jackson A, Hunt M et al (2012b) Esophageal toxicity from high-dose, single-fraction paraspinal stereotactic radiosurgery. Int J Radiat Oncol Biol Phys 83(5):e661–e667
Cvek J, Neuwirth R, Knybel L et al (2014) Cardiac radiosurgery for malignant ventricular tachycardia. Cureus 6(7):e190
Dahele M, Palma D, Lagerwaard F et al (2011) Radiological changes after stereotactic radiotherapy for stage I lung cancer. J Thorac Oncol 6(7):1221–1228
Dahele M, Verbakel W, Cuijpers J et al (2012) An analysis of patient positioning during stereotactic lung radiotherapy performed without rigid external immobilization. Radiother Oncol 104(1):28–32
Dalah E, Moraru I, Paulson E et al (2014) Variability of target and normal structure delineation using multimodality imaging for radiation therapy of pancreatic cancer. Int J Radiat Oncol Biol Phys 89(3):633–640
Daliani DD, Tannir NM, Papandreou CN et al (2009) Prospective assessment of systemic therapy followed by surgical removal of metastases in selected patients with renal cell carcinoma. BJU Int 104(4):456–460
Daly ME, Luxton G, Choi CY et al (2012) Normal tissue complication probability estimation by the Lyman-Kutcher-Burman method does not accurately predict spinal cord tolerance to stereotactic radiosurgery. Int J Radiat Oncol Biol Phys 82(5):2025–2032
Darby SC, Cutter DJ, Boerma M et al (2010) Radiation-related heart disease: current knowledge and future prospects. Int J Radiat Oncol Biol Phys 76(3):656–665
Dasu A (2007) Is the alpha/beta value for prostate tumours low enough to be safely used in clinical trials? Clin Oncol (R Coll Radiol) 19(5):289–301
Dawson LA, Normolle D, Balter JM et al (2002) Analysis of radiation-induced liver disease using the Lyman NTCP model. Int J Radiat Oncol Biol Phys 53(4):810–821
Dawson LA, Eccles C, Craig T (2006) Individualized image guided iso-NTCP based liver cancer SBRT. Acta Oncol 45(7):856–864
Dawson LA, Toronto O, Zhu A et al (2013) RTOG 1112 randomized phase III study of Sorafenib versus stereotactic bosy radiation therapy follwoed by sorafenib in hepatocelluar carcinoma. (www.RTOG.org)
De Meerleer G, Khoo V, Escudier B et al (2014) Radiotherapy for renal-cell carcinoma. Lancet Oncol 15(4):e170–e177
Desai A, Rai H, Haas J et al (2015) A retrospective review of CyberKnife stereotactic body radiotherapy for adrenal tumors (primary and metastatic): Winthrop University Hospital experience. Front Oncol 5:185
Deschavanne PJ, Fertil B (1996) A review of human cell radiosensitivity in vitro. Int J Radiat Oncol Biol Phys 34(1):251–266
Deshmukh A, Patel NJ, Pant S et al. (2013) Inhospital complications associated with catheter ablation of atrial fibrillation in the united states between 2000–2010: analysis of 93,801 procedures. Circulation; CIRCULATIONAHA. 113.003862
Donat SM, Diaz M, Bishoff JT et al (2013) Follow-up for clinically localized renal neoplasms: AUA guideline. J Urol 190(2):407–416
van Dongen JA, van Slooten EA (1978) The surgical treatment of pulmonary metastases. Cancer Treat Rev 5(1):29–48
Eccles CL, Patel R, Simeonov AK et al (2011) Comparison of liver tumor motion with and without abdominal compression using cine-magnetic resonance imaging. Int J Radiat Oncol Biol Phys 79(2):602–608
Edwards BK, Howe HL, Ries LA et al (2002) Annual report to the nation on the status of cancer, 1973–1999, featuring implications of age and aging on US cancer burden. Cancer 94(10):2766–2792
Emami B, Lyman J, Brown A et al (1991) Tolerance of normal tissue to therapeutic irradiation. Int J Radiat Oncol Biol Phys 21(1):109–122
Fakiris AJ, McGarry RC, Yiannoutsos CT et al (2009) Stereotactic body radiation therapy for early-stage non-small-cell lung carcinoma: four-year results of a prospective phase II study. Int J Radiat Oncol Biol Phys 75(3):677–682
Falcoz PE, Conti M, Brouchet L et al (2007) The thoracic surgery scoring system (Thoracoscore): risk model for in-hospital death in 15,183 patients requiring thoracic surgery. J Thorac Cardiovasc Surg 133(2):325–332
Farnia B, Louis CU, Teh BS et al (2014) Stereotactic body radiation therapy (SBRT) for an isolated bone metastasis in an adolescent male with nasopharyngeal carcinoma. Pediatr Blood Cancer 61(8):1520
Farrag A, Voordeckers M, Tournel K et al (2010) Pattern of failure after helical tomotherapy in head and neck cancer. Strahlenther Onkol 186(9):511–516
Ferlay J, Shin HR, Bray F et al (2010) Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer 127(12):2893–2917
Ferlay J, Soerjomataram I, Ervik M et al. (2015) GLOBOCAN 2012 v1. 1, Cancer Incidence and Mortality Worldwide: IARC CancerBase No. 11 [Internet]. Lyon, France: International Agency for Research on Cancer; 2013. http://globocan.iarc.fr
Finnigan R, Lamprecht B, Barry T et al (2016) Inter-and intra-fraction motion in stereotactic body radiotherapy for spinal and paraspinal tumours using cone-beam CT and positional correction in six degrees of freedom. J Med Imag Radiat Oncol 60(1):112–118
Flanigan RC, Mickisch G, Sylvester R et al (2004) Cytoreductive nephrectomy in patients with metastatic renal cancer: a combined analysis. J Urol 171(3):1071–1076
Folkert MR, Bilsky MH, Tom AK et al (2014) Outcomes and toxicity for hypofractionated and single-fraction image-guided stereotactic radiosurgery for sarcomas metastasizing to the spine. Int J Radiat Oncol Biol Phys 88(5):1085–1091
Foote M, Letourneau D, Hyde D et al (2011) Technique for stereotactic body radiotherapy for spinal metastases. J Clin Neurosci 18(2):276–279
Foote M, Bailey M, Smith L et al (2015) Guidelines for safe practice of stereotactic body (ablative) radiation therapy. J Med Imaging Radiat Oncol 59(5):646–653
Formenti SC (2015) Is classical stereotactic radiotherapy the optimal partner for immunotherapy? Oncology 29(5):211305
Franzese C, Franceschini D, Cozzi L et al (2017) Minimally invasive stereotactical radio-ablation of adrenal metastases as an alternative to surgery. Cancer Res Treat 49(1):20–28
Fuks Z, Kolesnick R (2005) Engaging the vascular component of the tumor response. Cancer Cell 8(2):89–91
Garcia-Barros M, Paris F, Cordon-Cardo C et al (2003) Tumor response to radiotherapy regulated by endothelial cell apoptosis. Science 300(5622):1155–1159
Gardner EA, Sumanaweera TS, Blanck O et al (2012) In vivo dose measurement using TLDs and MOSFET dosimeters for cardiac radiosurgery. J App Clin Med Phys 13(3):3745
Garg AK, Wang XS, Shiu AS et al (2011) Prospective evaluation of spinal reirradiation by using stereotactic body radiation therapy. Cancer 117(15):3509–3516
Gerszten PC, Burton SA, Ozhasoglu C et al (2005) Stereotactic radiosurgery for spinal metastases from renal cell carcinoma. J Neurosurg Spine 3(4):288–295
Gerszten PC, Sahgal A, Sheehan JP et al (2013) A multi-national report on methods for institutional credentialing for spine radiosurgery. Radiat Oncol 8(1):158
Ghia AJ, Chang EL, Bishop AJ et al (2016) Single-fraction versus multifraction spinal stereotactic radiosurgery for spinal metastases from renal cell carcinoma: secondary analysis of phase I/II trials. J Neurosurg Spine 24(5):829–836
Gill B, Oermann E, Ju A et al (2012) Fiducial-free CyberKnife stereotactic body radiation therapy (SBRT) for single vertebral body metastases: acceptable local control and normal tissue tolerance with 5 fraction approach. Front Oncol 2:39
Gilson B, Lederman G, Qian G et al (2006) 2249: hypo-fractionated stereotactic extra-cranial radiosurgery (HFSR) for primary and metastatic renal cell carcinoma. Int J Radiat Oncol Biol Phys 66(3):S349
Goldstein SD, Ford EC, Duhon M et al (2010) Use of respiratory-correlated four-dimensional computed tomography to determine acceptable treatment margins for locally advanced pancreatic adenocarcinoma. Int J Radiat Oncol Biol Phys 76(2):597–602
Gorayski P, Burmeister B, Foote M (2015) Radiotherapy for cutaneous melanoma: current and future applications. Future Oncol 11(3):525–534
Goyal K, Einstein D, Ibarra RA et al (2012) Stereotactic body radiation therapy for nonresectable tumors of the pancreas. J Surg Res 174(2):319–325
Griffioen GH, Lagerwaard FJ, Haasbeek CJ et al (2014) A brief report on outcomes of stereotactic ablative radiotherapy for a second primary lung cancer: evidence in support of routine CT surveillance. J Thorac Oncol 9(8):1222–1225
Guckenberger M, Sweeney RA, Flickinger JC et al (2011) Clinical practice of image-guided spine radiosurgery—results from an international research consortium. Radiat Oncol 6(1):172
Guckenberger M, Klement RJ, Allgauer M et al (2013a) Applicability of the linear-quadratic formalism for modeling local tumor control probability in high dose per fraction stereotactic body radiotherapy for early stage non-small cell lung cancer. Radiother Oncol 109(1):13–20
Guckenberger M, Allgauer M, Appold S et al (2013b) Safety and efficacy of stereotactic body radiotherapy for stage 1 non-small-cell lung cancer in routine clinical practice: a patterns-of-care and outcome analysis. J Thorac Oncol 8(8):1050–1058
Guckenberger M, Mantel F, Gerszten PC et al (2014) Safety and efficacy of stereotactic body radiotherapy as primary treatment for vertebral metastases: a multi-institutional analysis. Radiat Oncol 9:226
Guckenberger M, Klement RJ, Allgauer M et al (2016) Local tumor control probability modeling of primary and secondary lung tumors in stereotactic body radiotherapy. Radiother Oncol 118(3):485–491
Guiou M, Mayr NA, Kim EY et al (2012) Stereotactic body radiotherapy for adrenal metastases from lung cancer. J Radiat Oncol 1(2):155–163
Gunjur A, Duong C, Ball D et al (2014) Surgical and ablative therapies for the management of adrenal ‘oligometastases’—a systematic review. Cancer Treat Rev 40(7):838–846
Gurka MK, Collins SP, Slack R et al (2013) Stereotactic body radiation therapy with concurrent full-dose gemcitabine for locally advanced pancreatic cancer: a pilot trial demonstrating safety. Radiat Oncol 8(1):44
Haasbeek CJ, Lagerwaard FJ, Antonisse ME et al (2010) Stage I nonsmall cell lung cancer in patients aged > or =75 years: outcomes after stereotactic radiotherapy. Cancer 116(2):406–414
Haasbeek CJ, Palma D, Visser O et al (2012) Early-stage lung cancer in elderly patients: a population-based study of changes in treatment patterns and survival in the Netherlands. Ann Oncol 23(10):2743–2747
Hannan R, Ishihara D, Louder K et al (2016) Phase II trial of high-dose interleukin-2 (IL-2) and stereotactic radiation therapy (SABR) for metastatic clear cell renal cell carcinoma (ccRCC): interim analysis, ASCO annual meeting proceedings
Hara W, Loo BW, Goffinet DR et al (2008) Excellent local control with stereotactic radiotherapy boost after external beam radiotherapy in patients with nasopharyngeal carcinoma. Int J Radiat Oncol Biol Phys 71(2):393–400
Haseltine JM, Rimner A, Gelblum DY et al (2016) Fatal complications after stereotactic body radiation therapy for central lung tumors abutting the proximal bronchial tree. Pract Radiat Oncol 6(2):e27–e33
Hashmi A, Guckenberger M, Kersh R et al (2016) Re-irradiation stereotactic body radiotherapy for spinal metastases: a multi-institutional outcome analysis. J Neurosurg Spine 25(5):646–653
Heerkens HD, van Vulpen M, van den Berg CA et al (2014) MRI-based tumor motion characterization and gating schemes for radiation therapy of pancreatic cancer. Radiother Oncol 111(2):252–257
Helena AY, Sima CS, Huang J et al (2013) Local therapy with continued EGFR tyrosine kinase inhibitor therapy as a treatment strategy in EGFR-mutant advanced lung cancers that have developed acquired resistance to EGFR tyrosine kinase inhibitors. J Thorac Oncol 8(3):346–351
Hellman S, Weichselbaum RR (1995) Oligometastases. J Clin Oncol 13(1):8–10
Herder GJ, van Tinteren H, Golding RP et al (2005) Clinical prediction model to characterize pulmonary nodules: validation and added value of 18F-fluorodeoxyglucose positron emission tomography. Chest 128(4):2490–2496
Herfarth KK, Hof H, Bahner ML et al (2003) Assessment of focal liver reaction by multiphasic CT after stereotactic single-dose radiotherapy of liver tumors. Int J Radiat Oncol Biol Phys 57(2):444–451
Herman JM, Chang DT, Goodman KA et al (2015) Phase 2 multi-institutional trial evaluating gemcitabine and stereotactic body radiotherapy for patients with locally advanced unresectable pancreatic adenocarcinoma. Cancer 121(7):1128–1137
Heron DE, Ferris RL, Karamouzis M et al (2009) Stereotactic body radiotherapy for recurrent squamous cell carcinoma of the head and neck: results of a phase I dose-escalation trial. Int J Radiat Oncol Biol Phys 75(5):1493–1500
Heron DE, Rajagopalan MS, Stone B et al (2012) Single-session and multisession CyberKnife radiosurgery for spine metastases—University of Pittsburgh and Georgetown University experience: clinical article. J Neurosurg Spine 17(1):11–18
Higton AM, Monach J, Congleton J (2010) Investigation and management of lung cancer in older adults. Lung Cancer 69(2):209–212
Hiniker SM, Rangaswami A, Lungren MP et al (2016) Stereotactic body radiotherapy for pediatric hepatocellular carcinoma with central biliary obstruction. Pediatr Blood Cancer. doi:10.1002/pbc.26330
Hodges JC, Lotan Y, Boike TP et al (2012) Cost-effectiveness analysis of stereotactic body radiation therapy versus intensity-modulated radiation therapy: an emerging initial radiation treatment option for organ-confined prostate cancer. J Oncol Pract 8(3S):e31s–e37s
Hoopes DJ, Tann M, Fletcher JW et al (2007) FDG-PET and stereotactic body radiotherapy (SBRT) for stage I non-small-cell lung cancer. Lung Cancer 56(2):229–234
Hoyer M, Roed H, Sengelov L et al (2005) Phase-II study on stereotactic radiotherapy of locally advanced pancreatic carcinoma. Radiother Oncol 76(1):48–53
Hoyer M, Swaminath A, Bydder S et al (2012) Radiotherapy for liver metastases: a review of evidence. Int J Radiat Oncol Biol Phys 82(3):1047–1057
Huang K, Dahele M, Senan S et al (2012) Radiographic changes after lung stereotactic ablative radiotherapy (SABR)–can we distinguish recurrence from fibrosis? A systematic review of the literature. Radiother Oncol 102(3):335–342
Huang K, Senthi S, Palma DA et al (2013) High-risk CT features for detection of local recurrence after stereotactic ablative radiotherapy for lung cancer. Radiother Oncol 109(1):51–57
Huguet F, Yorke ED, Davidson M et al (2015) Modeling pancreatic tumor motion using 4-dimensional computed tomography and surrogate markers. Int J Radiat Oncol* Biol* Phys 91(3):579–587
Hussain SM, Semelka RC (2005) Hepatic imaging: comparison of modalities. Radiol Clin N Am 43(5):929–947. ix
Hyde D, Lochray F, Korol R et al (2012) Spine stereotactic body radiotherapy utilizing cone-beam CT image-guidance with a robotic couch: intrafraction motion analysis accounting for all six degrees of freedom. Int J Radiat Oncol* Biol* Phys 82(3):e555–e562
Iannuccilli JD, Grand DJ, Dupuy DE et al (2014) Percutaneous ablation for small renal masses—imaging follow-up. Sem Intervent Radiol 31(1):50–63
Inoue T, Kinoshita H, Komai Y et al (2012) Two cases of gastrointestinal perforation after radiotherapy in patients receiving tyrosine kinase inhibitor for advanced renal cell carcinoma. World J Surg Oncol 10(1):167
Ipsen S, Blanck O, Oborn B et al (2014) Radiotherapy beyond cancer: target localization in real-time MRI and treatment planning for cardiac radiosurgery. Med Phys 41(12):120702
Jabbari S, Gerszten PC, Ruschin M et al (2016) Stereotactic body radiotherapy for spinal metastases: practice guidelines, outcomes, and risks. Cancer J 22(4):280–289
Jackson P, Foroudi F, Pham D et al (2014) Short communication: timeline of radiation-induced kidney function loss after stereotactic ablative body radiotherapy of renal cell carcinoma as evaluated by serial 99m Tc-DMSA SPECT/CT. Radiat Oncol 9(1):1
James ND, Sydes MR, Clarke NW et al (2016) Addition of docetaxel, zoledronic acid, or both to first-line long-term hormone therapy in prostate cancer (STAMPEDE): survival results from an adaptive, multiarm, mutistage, platform randomized controlled trial. Lancet 357(10024):1163–1177
Jarraya H, Borde P, Mirabel X et al (2015) Lobulated enhancement evaluation in the follow-up of liver metastases treated by stereotactic body radiation therapy. Int J Radiat Oncol Biol Phys 92(2):292–298
Jensen NK, Mulder D, Lock M et al (2014) Dynamic contrast enhanced CT aiding gross tumor volume delineation of liver tumors: an interobserver variability study. Radiother Oncol 111(1):153–157
Jeon TY, Kim CK, Kim J et al (2015) Assessment of early therapeutic response to sorafenib in renal cell carcinoma xenografts by dynamic contrast-enhanced and diffusion-weighted MR imaging. Br J Radiol 88(1053):20150163
Jhaveri PM, Teh BS, Paulino AC et al (2012) A dose-response relationship for time to bone pain resolution after stereotactic body radiotherapy (SBRT) for renal cell carcinoma (RCC) bony metastases. Acta Oncol 51(5):584–588
Jung J, Yoon SM, Kim SY et al (2013) Radiation-induced liver disease after stereotactic body radiotherapy for small hepatocellular carcinoma: clinical and dose-volumetric parameters. Radiat Oncol 8(1):249
Jung J, Yoon SM, Park HC et al (2016) Radiotherapy for adrenal metastasis from hepatocellular carcinoma: a multi-institutional retrospective study (KROG 13-05). PLoS One 11(3):e0152642
Juusela H, Malmio K, Alfthan O et al (1997) Preoperative irradiation in the treatment of renal adenocarcinoma. Scand J Urol Nephrol 11(3):277–281
Kaizu T, Karasawa K, Tanaka Y et al (1989) Radiotherapy for osseous metastases from hepatocellular carcinoma: a retrospective study of 57 patients. Am J Gastroenterol 93(11):2167–2171
Kang SK, Zhang A, Pandharipande PV et al (2015) DWI for renal mass characterization: systematic review and meta-analysis of diagnostic test performance. AJR Am J Roentgenol 205(2):317–324
Kao J, Packer S, Vu HL et al (2009) Phase 1 study of concurrent sunitinib and image-guided radiotherapy followed by maintenance sunitinib for patients with oligometastases: acute toxicity and preliminary response. Cancer 115(15):3571–3580
Kao J, Chen CT, Tong CC et al (2014) Concurrent sunitinib and stereotactic body radiotherapy for patients with oligometastases. Targeted Oncol 9(2):145–153
Karam I, Poon I, Lee J et al (2015) Stereotactic body radiotherapy for head and neck cancer: an addition to the armamentarium against head and neck cancer. Future Oncol (London, England) 11(21):2937–2947
Karamichalakis N, Letsas KP, Vlachos K et al (2015) Managing atrial fibrillation in the very elderly patient: challenges and solutions. Vasc Health Risk Manage 11:555
Kasibhatla M, Steinberg P, Meyer J et al (2007) Radiation therapy and sorafenib: clinical data and rationale for the combination in metastatic renal cell carcinoma. Clin Genitourin Cancer 5(4):291–294
Katoh N, Onimaru R, Sakuhara Y et al (2008) Real-time tumor-tracking radiotherapy for adrenal tumors. Radiother Oncol 87(3):418–424
Katz AJ, Kang J (2014a) Stereotactic body radiotherapy as treatment for organ confined low- and intermediate-risk prostate carcinoma, a 7-year study. Front Oncol 4:240
Katz A, Kang J (2014b) Stereotactic body radiotherapy with or without external beam radiation as treatment for organ confined high-risk prostate carcinoma: a six year study. Radiat Oncol 9(1):1
Katz AJ, Santoro M (2010) Quality of life and efficacy for stereotactic body radiotherapy for treatment of organ confined prostate cancer. Annual Meeting of the Association for Radiation Oncology, San Diego, CA
Katz AJ, Santoro M, Ashley R et al (2010) Stereotactic body radiotherapy for organ-confined prostate cancer. BMC Urol 10:1
Kawaguchi K, Sato K, Yamada H et al (2012) Stereotactic radiosurgery in combination with chemotherapy as primary treatment for head and neck cancer. J Oral Maxillofacial Surg 70(2):461–472
Keall PJ, Mageras GS, Balter JM et al (2006) The management of respiratory motion in radiation oncology report of AAPM task group 76a. Med Phys 33(10):3874–3900
Kelsey CR, Schefter T, Nash SR et al (2005) Retrospective clinicopathologic correlation of gross tumor size of hepatocellular carcinoma: implications for stereotactic body radiotherapy. Am J Clin Oncol 28(6):576–580
Kestin L, Grills I, Guckenberger M et al (2014) Dose-response relationship with clinical outcome for lung stereotactic body radiotherapy (SBRT) delivered via online image guidance. Radiother Oncol 110(3):499–504
Khan L, Chiang A, Zhang L et al (2015a) Prophylactic dexamethasone effectively reduces the incidence of pain flare following spine stereotactic body radiotherapy (SBRT): a prospective observational study. Support Care Cancer 23(10):2937–2943
Khan L, Tjong M, Raziee H et al (2015b) Role of stereotactic body radiotherapy for symptom control in head and neck cancer patients. Support Care Cancer 23(4):1099–1103
Kim MS, Keum KC, Cha JH et al (2013) Stereotactic body radiotherapy with helical tomotherapy for pain palliation in spine metastasis. Technol Cancer Res Treat 12(4):363–370
King CR, Brooks JD, Gill H et al (2012) Long-term outcomes from a prospective trial of stereotactic body radiotherapy for low-risk prostate cancer. Int J Radiat Oncol Biol Phys 82(2):877–882
King CR, Freema D, Kaplan I et al (2013a) Stereotactic body radiotherapy for localized prostate cancer: pooled analysis from a multi-institutional consortium of prospective phase II trials. Radiother Oncol 109(2):217–221
King CR, Collins S, Fuller D et al (2013b) Health-related quality of life after stereotactic body radiation therapy for localized prostate cancer: results from a multi-institutional consortium of prospective trials. Int J Radiat Oncol Biol Phys 87(5):939–945
Kirkbride P, Cooper T (2011) Stereotactic body radiotherapy. Guidelines for commissioners, providers and clinicians: a national report. Clin Oncol (R Coll Radiol) 23(3):163–164
Kleibeuker EA, Matthijs A, Verheul H et al (2015) Combining radiotherapy with sunitinib: lessons (to be) learned. Angiogenesis 18(4):385–395
Klein J, Korol R, Lo SS et al (2014) Stereotactic body radiotherapy: an effective local treatment modality for hepatocellular carcinoma. Future Oncol 10(14):2227–2241
Klekamp J, Samii H (1998) Surgical results for spinal metastases. Acta Neurochir 140(9):957–967
Kodani N, Yamazaki H, Tsubokura T et al (2011) Stereotactic body radiation therapy for head and neck tumor: disease control and morbidity outcomes. J Radiat Res 52(1):24–31
Koong AC, Le QT, Ho A et al (2004) Phase I study of stereotactic radiosurgery in patients with locally advanced pancreatic cancer. Int J Radiat Oncol Biol Phys 58(4):1017–1021
Koong AC, Christofferson E, Le QT et al (2005) Phase II study to assess the efficacy of conventionally fractionated radiotherapy followed by a stereotactic radiosurgery boost in patients with locally advanced pancreatic cancer. Int J Radiat Oncol Biol Phys 63(2):320–323
Kothari G, Foroudi F, Gill S et al (2015) Outcomes of stereotactic radiotherapy for cranial and extracranial metastatic renal cell carcinoma: a systematic review. Acta Oncol 54(2):148–157
Koto M, Takai Y, Ogawa Y et al (2007) A phase II study on stereotactic body radiotherapy for stage I non-small cell lung cancer. Radiother Oncol 85(3):429–434
Kry SF, Alvarez P, Molineu A et al (2013) Algorithms used in heterogeneous dose calculations show systematic differences as measured with the radiological physics Center’s anthropomorphic thorax phantom used for RTOG credentialing. Int J Radiat Oncol Biol Phys 85(1):e95–e100
Kudo M (2015) Clinical practice guidelines for hepatocellular carcinoma differ between Japan, United States, and Europe. Liver Cancer 4:85–95
Kumar R, Xiu Y, Yu JQ et al (2004) 18F-FDG PET in evaluation of adrenal lesions in patients with lung cancer. J Nucl Med 45(12):2058–2062
Kunkle DA, Uzzo RG (2008) Cryoablation or radiofrequency ablation of the small renal mass: a meta-analysis. Cancer 113(10):2671–2680
Kupelian PA, Willoughby TR, Reddy CA et al (2007) Hypofractionated intensity-modulated radiotherapy (70 Gy at 2.5 Gy per fraction) for localized prostate cancer: cleveland clinic experience. Int J Radiat Oncol Biol Phys 68(5):1424–1430
Lagerwaard FJ, Haasbeek CJ, Smit EF et al (2008) Outcomes of risk-adapted fractionated stereotactic radiotherapy for stage I non-small-cell lung cancer. Int J Radiat Oncol Biol Phys 70(3):685–692
Lagerwaard FJ, Verstegen NE, Haasbeek CJ (2012) Outcomes of stereotactic ablative radiotherapy in patients with potentially operable stage I non-small cell lung cancer. Int J Radiat Oncol Biol Phys 83(1):348–353
Langen KM (2001) Jones DT (2001) organ motion and its management. Int J Radiat Oncol Biol Phys 50(1):265–278
Lartigau EF, Tresch E, Thariat J et al (2013) Multi institutional phase II study of concomitant stereotactic reirradiation and cetuximab for recurrent head and neck cancer. Radiother Oncol 109(2):281–285
Lau W-Y, Sangro B, Chen P-J et al (2013) Treatment for hepatocellular carcinoma with portal vein tumor thrombosis: the emerging role for radioembolization using yttrium-90. Oncology 84(5):311–318
Laufer I, Iorgulescu JB, Chapman T et al (2013) Local disease control for spinal metastases following “separation surgery” and adjuvant hypofractionated or high-dose single-fraction stereotactic radiosurgery: outcome analysis in 186 patients: clinical article. J Neurosurg Spine 18(3):207–214
Lausch A, Sinclair K, Lock M et al (2013) Determination and comparison of radiotherapy dose responses for hepatocellular carcinoma and metastatic colorectal liver tumours. Br J Radiol 86(1027):20130147
Lawrence TS, Robertson JM, Anscher MS et al (1995) Hepatic toxicity resulting from cancer treatment. Int J Radiat Oncol Biol Phys 31(5):1237–1248
Le QT, Tate D, Koong A et al (2003) Improved local control with stereotactic radiosurgical boost in patients with nasopharyngeal carcinoma. Int J Radiat Oncol Biol Phys 56(4):1046–1054
Lee Y, Auh SL, Wang Y et al (2009a) Therapeutic effects of ablative radiation on local tumor require CD8+ T cells: changing strategies for cancer treatment. Blood 114(3):589–595
Lee MT, Kim JJ, Dinniwell R et al (2009b) Phase I study of individualized stereotactic body radiotherapy of liver metastases. J Clin Oncol 27(10):1585–1591
Lee DS, Kim YS, Cheon JS et al (2012) Long-term outcome and toxicity of hypofractionated stereotactic body radiotherapy as a boost treatment for head and neck cancer: the importance of boost volume assessment. Radiat Oncol (London, England) 7:85-717X-7-85
Lee SH, Tatsui CE, Ghia AJ et al (2016) Can the spinal instability neoplastic score prior to spinal radiosurgery predict compression fractures following stereotactic spinal radiosurgery for metastatic spinal tumor?: a post hoc analysis of prospective phase II single-institution trials. J Neuro-Oncol 126(3):509–517
Lesurtel M, Müllhaupt B, Pestalozzi B et al (2006) Transarterial chemoembolization as a bridge to liver transplantation for hepatocellular carcinoma: an evidence-based analysis. Am J Transplant 6(11):2644–2650
Li J, Yu W, Tiwary R et al (2010) alpha-TEA-induced death receptor dependent apoptosis involves activation of acid sphingomyelinase and elevated ceramide-enriched cell surface membranes. Cancer Cell Int 10(1):40
Lin CS, Jen YM, Chiu SY et al (2006) Treatment of portal vein tumor thrombosis of hepatoma patients with either stereotactic radiotherapy or three-dimensional conformal radiotherapy. Jpn J Clin Oncol 36(4):212–217
Lindberg K, Nyman J, Riesenfeld Källskog V et al (2015) Long-term results of a prospective phase II trial of medically inoperable stage I NSCLC treated with SBRT–the Nordic experience. Acta Oncol 54(8):1096–1104
Ling DC, Vargo JA, Ferris RL et al (2016) Risk of severe toxicity according to site of recurrence in patients treated with stereotactic body radiation therapy for recurrent head and neck cancer. Int J Radiat Oncol* Biol* Phys 95(3):973–980
Livsey JE, Cowan RA, Wylie JP et al (2003) Hypofractionated conformal radiotherapy in carcinoma of the prostate: five-year outcome analysis. Int J Radiat Oncol Biol Phys 57(5):1254–1259
Llovet JM, Fuster J, Bruix J et al (2004) The Barcelona approach: diagnosis, staging, and treatment of hepatocellular carcinoma. Liver Transpl 10(2 Suppl 1):S115–SS20
Lo SS, Sahgal A, Wang JZ et al (2010) Stereotactic body radiation therapy for spinal metastases. Discov Med 9(47):289–296
Lo SS, Moffatt-Bruce SD, Dawson LA et al (2011) The role of local therapy in the management of lung and liver oligometastases. Nat Rev Clin Oncol 8(7):405–416
Lo A, Loo B, Maguire P et al (2013) SBRT for cardiac arrhythmia ablation. J Radiosurge & SBRT 2:15
Lo CH, Huang WY, Chao HL et al (2014) Novel application of stereotactic ablative radiotherapy using CyberKnife® for early-stage renal cell carcinoma in patients with pre-existing chronic kidney disease: initial clinical experiences. Oncol Lett 8(1):355–360
Lo SS, Foote M, Siva S et al (2016) Technical know-how in stereotactic ablative radiotherapy (SABR). J Med Radiat Sci 63(1):5–8
Loblaw D, Sethukavalan P, Cheung P et al (2013) Comparison of biochemical and toxicity outcomes from a contemporaneous cohort study of low-risk prostate cancer treated with different radiation techniques. Int J Radiat Oncol* Biol* Phys 87(2):S26
Lock MI, Hoyer M, Bydder SA et al (2012) An international survey on liver metastases radiotherapy. Acta Oncol 51(5):568–574
Lock M, Callan L, Gaede S et al (2014) Identification of patients with liver cancer that will not benefit from radiation. Int J Radiat Oncol Biol Phys 1(90):S594
Lock M, Malayeri AA, Mian OY et al (2016) Computed tomography imaging assessment of postexternal beam radiation changes of the liver. Future Oncol 12(23):2729–2739
Loehrer PJ, Feng Y, Cardenes H et al (2011) Gemcitabine alone versus gemcitabine plus radiotherapy in patients with locally advanced pancreatic cancer: an eastern cooperative oncology group trial. J Clin Oncol 29(31):4105–4112
Loganathan RS, Stover DE, Shi W et al (2006) Prevalence of COPD in women compared to men around the time of diagnosis of primary lung cancer. Chest 129(5):1305–1312
Lou F, Huang J, Sima CS et al (2013) Patterns of recurrence and second primary lung cancer in early-stage lung cancer survivors followed with routine computed tomography surveillance. J Thorac Cardiovasc Surg 145(1):75–81. discussion 81-2
Louie AV, van Werkhoven E, Chen H et al (2015) Patient reported outcomes following stereotactic ablative radiotherapy or surgery for stage IA non-small-cell lung cancer: results from the ROSEL multicenter randomized trial. Radiother Oncol 117(1):44–48
Lowther NJ (2016) Non-invasive cardiac radiosurgery with MRI guidance: a ground-truth for real-time target localisation using the XCAT phantom, University of Canterbury
Luketich JD, Burt ME (1996) Does resection of adrenal metastases from non-small cell lung cancer improve survival? Ann Thorac Surg 62(6):1614–1616
Lukka H, Hayter C, Julian JA et al (2005) Randomized trial comparing two fractionation schedules for patients with localized prostate cancer. J Clin Oncol 23(25):6132–6138
Lutz S, Berk L, Chang E, Chow E et al (2011) Palliative radiotherapy for bone metastases: an ASTRO evidence-based guideline. Int J Radiat Oncol Biol Phys 79(4):965–976
Mageras GS, Yorke E (2004) Deep inspiration breath hold and respiratory gating strategies for reducing organ motion in radiation treatment. Semin Radiat Oncol 14(1):65–75
Maguire PJ, Gardner E, Jack AB et al (2011) Cardiac radiosurgery (CyberHeart™) for treatment of arrhythmia: physiologic and histopathologic correlation in the porcine model. Cureus 3(8):e32
Mahadevan A, Jain S, Goldstein M et al (2010) Stereotactic body radiotherapy and gemcitabine for locally advanced pancreatic cancer. Int J Radiat Oncol Biol Phys 78(3):735–742
Majewski W, Tabor M, Banaszek P et al (2016) The efficacy of stereotactic radiotherapy for metastases from renal cell carcinoma. Neoplasma 63(1):99–106
Mantz CA, Fernandez E et al (2013) Real-time target tracking prostate SBRT and the real-time tracking system 4D localization system: 5-year quality of life and disease outcomes. Int J Radiat Oncol* Biol* Phys 87(2):S393
McBride SM, Wong DS, Dombrowski JJ et al (2012) Hypofractionated stereotactic body radiotherapy in low-risk prostate adenocarcinoma. Cancer 118(15):3681–3690
McBride S, Wagner A, Kaplan I (2013) A phase 1 dose-escalation study of robotic radiosurgery in inoperable primary renal cell carcinoma. Int J Radiat Oncol Biol Phys 87(2):S84
McCammon R, Schefter TE, Gaspar LE et al (2009) Observation of a dose–control relationship for lung and liver tumors after stereotactic body radiation therapy. Int J Radiat Oncol Biol Phys 73(1):112–118
McDonald MW, Lawson J, Garg MK et al (2011) ACR appropriateness criteria retreatment of recurrent head and neck cancer after prior definitive radiation expert panel on radiation oncology-head and neck cancer. Int J Radiat Oncol Biol Phys 80(5):1292–1298
McDonald MW, Moore MG, Johnstone PA (2012) Risk of carotid blowout after reirradiation of the head and neck: a systematic review. Int J Radiat Oncol Biol Phys 82(3):1083–1089
McGarry RC, Papiez L, Williams M et al (2005) Stereotactic body radiation therapy of early-stage non-small-cell lung carcinoma: phase I study. Int J Radiat Oncol Biol Phys 63(4):1010–1015
McGinn CJ, Ten Haken RK, Ensminger WD et al (1998) Treatment of intrahepatic cancers with radiation doses based on a normal tissue complication probability model. J Clin Oncol 16(6):2246–2252
Meier R (2015) Dose-escalated robotic SBRT for stage I–II prostate cancer. Front Oncol 5:48
Mellon EA, Hoffe SE, Springett GM et al (2015) Long-term outcomes of induction chemotherapy and neoadjuvant stereotactic body radiotherapy for borderline resectable and locally advanced pancreatic adenocarcinoma. Acta Oncol 54(7):979–985
Mendez Romero A, Wunderink W, Hussain SM et al (2006) Stereotactic body radiation therapy for primary and metastatic liver tumors: a single institution phase i-ii study. Acta Oncol 45(7):831–837
Miller JA, Balagamwala EH, Angelov L et al (2016) Stereotactic radiosurgery for the treatment of primary and metastatic spinal sarcomas. Technol Cancer Res Treat. doi:10.1177/1533034616643221
Minn AY, Schellenberg D, Maxim P et al (2009) Pancreatic tumor motion on a single planning 4D-CT does not correlate with intrafraction tumor motion during treatment. Am J Clin Oncol 32(4):364–368
Mitchell IC, Nwariaku FE (2007) Adrenal masses in the cancer patient: surveillance or excision. Oncologist 12(2):168–174
Mittal S, El-Serag HB (2013) Epidemiology of HCC: consider the population. J Clin Gastroenterol 47:S2
Mittendorf EA, Lim SJ, Schacherer CW et al (2008) Melanoma adrenal metastasis: natural history and surgical management. Am J Surg 195(3):363–368. discussion 368-9
Mole R (1953) Whole body irradiation—radiobiology or medicine? Br J Radiol 26(305):234–241
Moningi S, Dholakia AS, Raman SP et al (2015) The role of stereotactic body radiation therapy for pancreatic cancer: a single-institution experience. Ann Surg Oncol 22(7):2352–2358
Moss AJ, Greenberg H, Case RB et al (2004) Long-term clinical course of patients after termination of ventricular tachyarrhythmia by an implanted defibrillator. Circulation 110(25):3760–3765
Motzer RJ, Bander NH, Nanus DM (1996) Renal-cell carcinoma. N Engl J Med 335(12):865–875
Motzer RJ, Hutson TE, Tomczak P et al (2009) Overall survival and updated results for sunitinib compared with interferon alfa in patients with metastatic renal cell carcinoma. J Clin Oncol 27(22):3584–3590
Motzer RJ, Escudier B, McDermott DF et al (2015a) Nivolumab versus Everolimus in advanced renal-cell carcinoma. N Engl J Med 373(19):1803–1813
Motzer RJ, Rini BI, McDermott DF et al (2015b) Nivolumab for metastatic renal cell carcinoma: results of a randomized phase II trial. J Clin Oncol 33(13):1430–1437
Muth A, Persson F, Jansson S et al (2010) Prognostic factors for survival aftyer surgery for adrenal metastasis. Eur J Surg Oncol 36(7):699–704
Naderi S, Wang Y, Miller AL et al (2014) The impact of age on the epidemiology of atrial fibrillation hospitalizations. Am J Med 127(2):158 e1–158 e7
Nagata Y, Takayama K, Matsuo Y et al (2005) Clinical outcomes of a phase I/II study of 48 Gy of stereotactic body radiotherapy in 4 fractions for primary lung cancer using a stereotactic body frame. Int J Radiat Oncol* Biol* Phys 63(5):1427–1431
Nagata Y, Hiraoka M, Shibata T et al (2015) Prospective trial of stereotactic body radiation therapy for both operable and inoperable T1N0M0 non-small cell lung cancer: Japan Clinical Oncology Group Study JCOG0403. Int J Radiat Oncol* Biol* Phys 93(5):989–996
Nair VJ, Szanto J, Vandervoort E et al (2013) CyberKnife for inoperable renal tumors: Canadian pioneering experience. Can J Urol 20(5):6944–6949
Nguyen Q-N, Shiu AS, Rhines LD et al (2010) Management of spinal metastases from renal cell carcinoma using stereotactic body radiotherapy. Int J Radiat Oncol* Biol* Phys 76(4):1185–1192
Ning S, Trisler K, Wessels BW et al (1997) Radiobiologic studies of radioimmunotherapy and external beam radiotherapy in vitro and in vivo in human renal cell carcinoma xenografts. Cancer 80(12 Suppl):2519–2528
Nomiya T, Tsuji H, Hirasawa N et al (2008) Carbon ion radiation therapy for primary renal cell carcinoma: initial clinical experience. Int J Radiat Oncol Biol Phys 72(3):828–833
Nyman J, Hallqvist A, Lund JA et al (2016) SPACE—a randomized study of SBRT vs conventional fractionated radiotherapy in medically inoperable stage I NSCLC. Radiother Oncol 121(1):1–8
O’Sullivan B, Huang SH, Siu LL et al (2013) Deintensification candidate subgroups in human papillomavirus-related oropharyngeal cancer according to minimal risk of distant metastasis. J Clin Oncol 31(5):543–550
Oliveri RS, Wetterslev J, Gluud C (2011) Transarterial (chemo)embolisation for unresectable hepatocellular carcinoma. Cochrane Database Syst Rev 3:CD004787
Onishi H, Shirato H, Nagata Y, Hiraoka M et al (2007) Hypofractionated stereotactic radiotherapy (HypoFXSRT) for stage I non-small cell lung cancer: updated results of 257 patients in a Japanese multi-institutional study. J Thorac Oncol 2(7 Suppl 3):S94–S100
Onishi H, Ozaki M, Kuriyama K et al (2012) Serious gastric ulcer event after stereotactic body radiotherapy (SBRT) delivered with concomitant vinorelbine in a patient with left adrenal metastasis of lung cancer. Acta Oncol 51(5):624–628
Oshiro Y, Takeda Y, Hirano S, Ito H et al (2011) Role of radiotherapy for local control of asymptomatic adrenal metastasis from lung cancer. Am J Clin Oncol 34(3):249–253
Ost P, Jereczek-Fossa BA, As NV et al (2016) Progression-free survival following stereotactic body radiotherapy for oligometastatic prostate cancer treatment-naive recurrence: a multi-institutional analysis. Eur Urol 69(1):9–12
Owen D, Iqbal F, Pollock BE et al (2015) Long-term follow-up of stereotactic radiosurgery for head and neck malignancies. Head Neck 37(11):1557–1562
Ozyigit G, Cengiz M, Yazici G et al (2011) A retrospective comparison of robotic stereotactic body radiotherapy and three-dimensional conformal radiotherapy for the reirradiation of locally recurrent nasopharyngeal carcinoma. Int J Radiat Oncol Biol Phys 81(4):e263–e268
Palma D, Lagerwaard F (2012) Rodrigues et al. curative treatment of stage I non-small-cell lung cancer in patients with severe COPD: stereotactic radiotherapy outcomes and systematic review. Int J Radiat Oncol Biol Phys 82(3):1149–1156
Pan H, Simpson DR, Mell LK et al (2011) A survey of stereotactic body radiotherapy use in the United States. Cancer 117(19):4566–4572
Parameswaran B, Lau E, Bergen N et al (2013) Dynamic contrast enhanced MR evaluation of inoperable renal tumours treated with stereotactic radiation: preliminary results: daunting but worthwhile? J Med Imag Radiat Oncol 57(Suppl 1):156
Park C, Papiez L, Zhang S et al (2008) Universal survival curve and single fraction equivalent dose: useful tools in understanding potency of ablative radiotherapy. Int J Radiat Oncol Biol Phys 70(3):847–852
Pastorino U, Buyse M, Friedel G et al (1997) Long-term results of lung metastasectomy: prognostic analyses based on 5206 cases. J Thorac Cardiovasc Surg 113(1):37–49
Paulino AC, Constine LS, Rubin P et al (2010) Normal tissue development, homeostasis, senescence, and the sensitivity to radiation injury across the age spectrum. Semin Radiat Oncol 20(1):12–20
Pham D, Kron T, Foroudi F et al (2014a) A review of kidney motion under free, deep and forced-shallow breathing conditions: implications for stereotactic ablative body radiotherapy treatment. Technol Cancer Res Treat 13(4):315–323
Pham D, Thompson A, Kron T et al (2014b) Stereotactic ablative body radiation therapy for primary kidney cancer: a 3-dimensional conformal technique associated with low rates of early toxicity. Int J Radiat Oncol Biol Phys 90(5):1061–1068
Pham D, Kron T, Styles C et al (2015) The use of dual vacuum stabilization device to reduce kidney motion for stereotactic radiotherapy planning. Technol Cancer Res Treat 14(2):149–157
Pollom EL, Alagappan M, von Eyben R et al (2014) Single- versus multifraction stereotactic body radiation therapy for pancreatic adenocarcinoma: outcomes and toxicity. Int J Radiat Oncol Biol Phys 90(4):918–925
Pompili M, Francica G, Ponziani FR et al (2013) Bridging and downstaging treatments for hepatocellular carcinoma in patients on the waiting list for liver transplantation. World J Gastroenterol 19(43):7515–7530
Ponsky L, Lo SS, Zhang Y et al (2015) Phase I dose-escalation study of stereotactic body radiotherapy (SBRT) for poor surgical candidates with localized renal cell carcinoma. Radiother Oncol 117(1):183–187
Potters L, Gaspar LE, Kavanagh B et al (2010) American Society for Therapeutic Radiology and Oncology (ASTRO) and American College of Radiology (ACR) practice guidelines for image-guided radiation therapy (IGRT). Int J Radiat Oncol Biol Phys 76(2):319–325
Qian G, Lowry J, Silverman P et al (2003) Stereotactic extra-cranial radiosurgery for renal cell carcinoma. Int J Radiat Oncol* Biol* Phys 57(2):S283
Quirk M, Kim YH, Saab S et al (2015) Management of hepatocellular carcinoma with portal vein thrombosis. World J Gastroenterol 21(12):3462–3471
Rajagopalan MS, Heron DE, Wegner RE et al (2013) Pathologic response with neoadjuvant chemotherapy and stereotactic body radiotherapy for borderline resectable and locally-advanced pancreatic cancer. Radiat Oncol 8(1):254
Rami-Porta R, Crowley JJ, Goldstraw P (2009) Review the revised TNM staging system for lung cancer. Ann Thorac Cardiovasc Surg 15(1):5
Ranck MC et al (2013) Stereotactic body radiotherapy for the treatment of oligometastatic renal cell carcinoma. Am J Clin Oncol 36(6):589–595
Ranck MC, Golden DW, Corbin KS et al (2013) Stereotactic body radiotherapy for the treatment of oligometastatic renal cell carcinoma. Am J Clin Oncol 36(6):589–595
Raz DJ, Zell JA, Ou SH et al (2007) Natural history of stage I non-small cell lung cancer: implications for early detection. Chest 132(1):193–199
Redmond KJ, Lo SS, Fisher C et al (2016) Post-operative spine stereotactic body radiotherapy (SBRT): a critical review to guide practice. Int J Radiat Oncol* Biol* Phys 95(5):1414–1428
Reynders K, Illidge T, Siva S et al (2015) The abscopal effect of local radiotherapy: using immunotherapy to make a rare event clinically relevant. Cancer Treat Rev 41(6):503–510
Ricardi U, Filippi AR, Guarneri A et al (2010) Stereotactic body radiation therapy for early stage non-small cell lung cancer: results of a prospective trial. Lung Cancer 68(1):72–77
Roh KW, Jang JS, Kim MS et al (2009) Fractionated stereotactic radiotherapy as reirradiation for locally recurrent head and neck cancer. Int J Radiat Oncol Biol Phys 74(5):1348–1355
Rose PS, Laufer I, Boland PJ et al (2009) Risk of fracture after single fraction image-guided intensity-modulated radiation therapy to spinal metastases. J Clin Oncol 27(30):5075–5079
Rose SC, Kikolski SG, Gish RG et al (2013) Society of Interventional Radiology critique and commentary on the Cochrane report on transarterial chemoembolization. Hepatology 57(4):1675–1676
Rowell NP, Williams C et al (2003) Radical radiotherapy for stage I/II non-small cell lung cancer in patients not sufficiently fit for or declining surgery (medically inoperable). The Cochrane Library
Ruhl R, Ludemann L, Czarnecka A et al (2010) Radiobiological restrictions and tolerance doses of repeated single-fraction hdr-irradiation of intersecting small liver volumes for recurrent hepatic metastases. Radiat Oncol 5(1):44
Rule W, Timmerman R, Tong L et al (2011) Phase I dose-escalation study of stereotactic body radiotherapy in patients with hepatic metastases. Ann Surg Oncol 18(4):1081–1087
Rwigema JC, Heron DE, Ferris RL et al (2011) The impact of tumor volume and radiotherapy dose on outcome in previously irradiated recurrent squamous cell carcinoma of the head and neck treated with stereotactic body radiation therapy. Am J Clin Oncol 34(4):372–379
Rwigema JC, Heron DE, Parikh SD et al (2012) Adjuvant stereotactic body radiotherapy for resected pancreatic adenocarcinoma with close or positive margins. J Gastrointest Cancer 43(1):70–76
Ryu S, Fang YF, Rock J et al (2003) Image-guided and intensity-modulated radiosurgery for patients with spinal metastasis. Cancer 97(8):2013–2018
Sahgal A, Ames C, Chou D et al (2009) Stereotactic body radiotherapy is effective salvage therapy for patients with prior radiation of spinal metastases. Int J Radiat Oncol* Biol* Phys 74(3):723–731
Sahgal A, Bilsky M, Chang EL et al (2011) Stereotactic body radiotherapy for spinal metastases: current status, with a focus on its application in the postoperative patient: a review. J Neurosurg Spine 14(2):151–166
Sahgal A, Roberge D, Schellenberg D et al (2012a) The Canadian association of radiation oncology scope of practice guidelines for lung, liver and spine stereotactic body radiotherapy. Clin Oncol (R Coll Radiol) 24(9):629–639
Sahgal A, Ma L, Weinberg V et al (2012b) Reirradiation human spinal cord tolerance for stereotactic body radiotherapy. Int J Radiat Oncol Biol Phys 82(1):107–116
Sahgal A, Weinberg V, Ma L et al (2013a) Probabilities of radiation myelopathy specific to stereotactic body radiation therapy to guide safe practice. Int J Radiat Oncol Biol Phys 85(2):341–347
Sahgal A, Atenafu EG, Chao S et al (2013b) Vertebral compression fracture after spine stereotactic body radiotherapy: a multi-institutional analysis with a focus on radiation dose and the spinal instability neoplastic score. J Clin Oncol 31(27):3426–3431
Sathishkumar S, Boyanovsky B, Karakashian AA et al (2005) Elevated sphingomyelinase activity and ceramide concentration in serum of patients undergoing high dose spatially fractionated radiation treatment: implications for endothelial apoptosis. Cancer Biol Ther 4(9):979–986
Schanne DH, Nestle U, Allgauer M et al (2015) Stereotactic body radiotherapy for centrally located stage I NSCLC: a multicenter analysis. Strahlenther Onkol 191(2):125–132
Schellenberg D, Kim J, Christman-Skieller C et al (2011) Single-fraction stereotactic body radiation therapy and sequential gemcitabine for the treatment of locally advanced pancreatic cancer. Int J Radiat Oncol Biol Phys 81(1):181–188
Schueneman AJ, Himmelfarb E, Geng L et al (2003) SU11248 maintenance therapy prevents tumor regrowth after fractionated irradiation of murine tumor models. Cancer Res 63(14):4009–4016
Sciubba DM, Gokaslan ZL (2006) Diagnosis and management of metastatic spine disease. Surg Oncol 15(3):141–151
Scorsetti M, Mancosu P, Navarria P et al (2011) Stereotactic body radiation therapy (SBRT) for adrenal metastases: a feasibility study of advanced techniques with modulated photons and protons. Strahlenther Onkol 187(4):238–244. doi:10.1007/s00066-011-2207-9. Epub 2011 Mar 25
Senthi S, Lagerwaard FJ, Haasbeek CJ et al (2012) Patterns of disease recurrence after stereotactic ablative radiotherapy for early stage non-small-cell lung cancer: a retrospective analysis. Lancet Oncol 13(8):802–809
Senthi S, Haasbeek CJ, Slotman BJ et al (2013) Outcomes of stereotactic ablative radiotherapy for central lung tumours: a systematic review. Radiother Oncol 106(3):276–282
Seo Y, Kim MS, Yoo S et al (2009) Stereotactic body radiation therapy boost in locally advanced pancreatic cancer. Int J Radiat Oncol Biol Phys 75(5):1456–1461
Seong J, Koom WS, Park HC (2005) Radiotherapy for painful bone metastases from hepatocellular carcinoma. Liver Int 25(2):261–265
Seong J, Lee IJ, Shim SJ et al (2009) A multicenter retrospective cohort study of practice patterns and clinical outcome on radiotherapy for hepatocellular carcinoma in Korea. Liver Int 29(2):147–152
Seung SK, Curti BD, Crittenden M et al (2012) Phase 1 study of stereotactic body radiotherapy and interleukin-2-tumor and immunological responses. Sci Transl Med 4(137):137ra74
Sharabi AB, Tran PT, Lim M et al (2015) Stereotactic radiation therapy combined with immunotherapy: augmenting the role of radiation in local and systemic treatment. Oncology 29(5):211304
Sharma A, Wong D, Weidlich G et al (2010) Noninvasive stereotactic radiosurgery (CyberHeart) for creation of ablation lesions in the atrium. Heart Rhythm 7(6):802–810
Shibamoto Y, Hashizume C, Baba F et al (2015) Stereotactic body radiotherapy using a radiobiology-based regimen for stage I non-small-cell lung cancer: five-year mature results. J Thorac Oncol 10(6):960–964
Shim SJ, Seong J, Han KH et al (2005) Local radiotherapy as a complement to incomplete transcatheter arterial chemoembolization in locally advanced hepatocellular carcinoma. Liver Int 25(6):1189–1196
Shirvani SM, Jiang J, Chang JY et al (2012) Comparative effectiveness of 5 treatment strategies for early-stage non-small cell lung cancer in the elderly. Int J Radiat Oncol Biol Phys 84(5):1060–1070
Siddiqui F, Patel M, Khan M et al (2009) Stereotactic body radiation therapy for primary, recurrent, and metastatic tumors in the head-and-neck region. Int J Radiat Oncol Biol Phys 74(4):1047–1053
Siddiqui F, Kunos CA, Paulino AC (2012) Stereotactic body radiation therapy in head and neck, gynecologic, and pediatric malignancies. J Radiat Oncol 1(1):31–42
Siegel RL, Miller KD, Jemal A (2015) Cancer statistics, 2015. CA: A Cancer J Clinicians 65(1):5–29
Siegel RL, Miller KD, Jemal A (2016) Cancer statistics, 2016. CA Cancer J Clin 66(1):7–30
Simpson J, Drzymala R, Rich K (2006) Stereotactic radiosurgery and radiotherapy. Technical basis of radiation therapy, pp 233–253
Siva S et al (2012) A systematic review of stereotactic radiotherapy ablation for primary renal cell carcinoma. BJU Int 110(11 Pt B): E737–743.
Siva S, MacManus M, Ball D (2010) Stereotactic radiotherapy for pulmonary oligometastases: a systematic review. J Thorac Oncol 5(7):1091–1099
Siva S, MacManus MP, Martin RF et al (2015) Abscopal effects of radiation therapy: a clinical review for the radiobiologist. Cancer Lett 356(1):82–90
Siva S, Jackson P, Kron T et al (2016a) Impact of stereotactic radiotherapy on kidney function in primary renal cell carcinoma: establishing a dose-response relationship. Radiother Oncol 118(3):540–546
Siva S, Daniels CP, Ellis RJ et al (2016b) Stereotactic ablative body radiotherapy for primary kidney cancer: what have we learned from prospective trials and what does the future hold? Future Oncol 12(5):601–606
Siva S, Ellis RJ, Ponsky L et al (2016c) Consensus statement from the international radiosurgery oncology consortium for kidney for primary renal cell carcinoma. Future Oncol 12(5):637–645
Soffen EM, Solin LJ, Rubenstein JH et al (1990) Palliative radiotherapy for symptomatic adrenal metastases. Cancer 65(6):1318–1320
Soltys SG, Kalani MY, Cheshier SH et al (2008) Stereotactic radiosurgery for a cardiac sarcoma: a case report. Technol Cancer Res Treat 7(5):363–368
Song SY, Choi W, Shin SS et al (2009) Fractionated stereotactic body radiation therapy for medically inoperable stage I lung cancer adjacent to central large bronchus. Lung Cancer 66(1):89–93
Song CW, Kim MS, Cho LC et al (2014) Radiobiological basis of SBRT and SRS. Int J Clin Oncol 19(4):570–578
Staehler M, Haseke N, Nuhn P et al (2011) Simultaneous anti-angiogenic therapy and single-fraction radiosurgery in clinically relevant metastases from renal cell carcinoma. BJU Int 108(5):673–678
Staehler M, Bader M, Schlenker B et al (2015) Single fraction radiosurgery for the treatment of renal tumors. J Urol 193(3):771–775
Stauder MC, Ni Laack N, Ahmed KA et al (2012) Stereotactic radiosurgery for patients with recurrent intracranial ependymomas. J Neuro-Oncol 108(3):507–512
Svedman C, Sandström P, Pisa P et al (2006) A prospective phase II trial of using extracranial stereotactic radiotherapy in primary and metastatic renal cell carcinoma. Acta Oncol 45(7):870–875
Svedman C, Karlsson K, Rutkowska E et al (2008) Stereotactic body radiotherapy of primary and metastatic renal lesions for patients with only one functioning kidney. Acta Oncol 47(8):1578–1583
Swaminath A, Chu W (2015) Stereotactic body radiotherapy for the treatment of medically inoperable primary renal cell carcinoma: current evidence and future directions. Can Urol Assoc J 9(7–8):275–280
Takeda A, Kunieda E, Fujii H et al (2013) Evaluation for local failure by 18 F-FDG PET/CT in comparison with CT findings after stereotactic body radiotherapy (SBRT) for localized non-small-cell lung cancer. Lung Cancer 79(3):248–253
Takiar V, Garden AS, Ma D et al (2016) Reirradiation of head and neck cancers with intensity modulated radiation therapy: outcomes and analyses. Int J Radiat Oncol Biol Phys 95(4):1117–1131
Takigawa M, Takahashi A, Kuwahara T et al (2014) Long-term follow-up after catheter ablation of paroxysmal atrial fibrillation: the incidence of recurrence and progression of atrial fibrillation. Circ Arrhythm Electrophysiol 7(2):267–273
Tang C, Hess K, Bishop AJ et al (2015) Creation of a prognostic index for spine metastasis to stratify survival in patients treated with spinal stereotactic radiosurgery: secondary analysis of mature prospective trials. Int J Radiat Oncol Biol Phys 93(1):118–125
Tanguturi SK, Wo JY, Zhu AX et al (2014) Radiation therapy for liver tumors: ready for inclusion in guidelines? Oncologist 19(8):868–879
Tanvetyanon T, Robinson LA, Schell MJ et al (2008) Outcomes of adrenalectomy for isolated synchronous versus metachronous adrenal metastases in non-small-cell lung cancer: a systematic review and pooled analysis. J Clin Oncol 26(7):1142–1147
Tate DJ, Adler JR Jr, Chang SD et al (1999) Stereotactic radiosurgical boost following radiotherapy in primary nasopharyngeal carcinoma: impact on local control. Int J Radiat Oncol Biol Phys 45(4):915–921
Taunk NK, Spratt DE, Bilsky M et al (2015) Spine radiosurgery in the management of renal cell carcinoma metastases. J Natl Compr Cancer Netw 13(6):801–809. quiz 809
Taunk NK, Kushner B, Ibanez K et al (2016) Short-interval retreatment with stereotactic body radiotherapy (SBRT) for pediatric neuroblastoma resulting in severe myositis. Pediatr Blood Cancer 63(4):731–733
Teh B, Bloch C, Galli-Guevara M et al (2007) The treatment of primary and metastatic renal cell carcinoma (RCC) with image-guided stereotactic body radiation therapy (SBRT). Biomed Imaging Interv J 3(1):e6
Tekatli H, Haasbeek N, Dahele M et al (2016) Outcomes of hypofractionated high-dose radiotherapy in poor-risk patients with “ultracentral” non-small cell lung cancer. J Thorac Oncol 11(7):1081–1089
Ten Haken RK, Martel MK, Kessler ML et al (1993) Use of Veff and iso-NTCP in the implementation of dose escalation protocols. Int J Radiat Oncol* Biol* Phys 27(3):689–695
Thariat J, Marcy PY, Lacout A et al (2011) Benefit of optimizing the dose to the carotid in hypofractionated stereotactic body reirradiation? Int J Radiat Oncol Biol Phys 81(5):1593–1594
Thibault I, Al-Omair A, Masucci GL et al (2014) Spine stereotactic body radiotherapy for renal cell cancer spinal metastases: analysis of outcomes and risk of vertebral compression fracture: clinical article. J Neurosurg Spine 21(5):711–718
Thibault I, Chang EL, Sheehan J et al (2015) Response assessment after stereotactic body radiotherapy for spinal metastasis: a report from the SPIne response assessment in Neuro-oncology (SPINO) group. Lancet Oncol 16(16):e595–e603
Thomas TO, Hasan S, Small W et al (2014) The tolerance of gastrointestinal organs to stereotactic body radiation therapy: what do we know so far? J Gastrointest Oncol 5(3):236
Timmerman R, Papiez L, McGarry R et al (2003) Extracranial stereotactic radioablation: results of a phase I study in medically inoperable stage I non-small cell lung cancer. Chest 124(5):1946–1955
Timmerman R, McGarry R, Yiannoutsos C et al (2006) Excessive toxicity when treating central tumors in a phase II study of stereotactic body radiation therapy for medically inoperable early-stage lung cancer. J Clin Oncol 24(30):4833–4839
Timmerman RD, Kavanagh BD, Cho LC et al (2007) Stereotactic body radiation therapy in multiple organ sites. J Clin Oncol 25(8):947–952
Timmerman R, Paulus R, Galvin J et al (2010) Stereotactic body radiation therapy for inoperable early stage lung cancer. JAMA 303(11):1070–1076
Tinkle CL, Shiao SL, Weinberg VK et al (2015) Comparison of stereotactic body radiotherapy and conventional external beam radiotherapy in renal cell carcinoma. ASCO annual meeting proceedings
Tomiyama N, Yasuhara Y, Nakajima Y et al (2006) CT-guided needle biopsy of lung lesions: a survey of severe complication based on 9783 biopsies in Japan. Eur J Radiol 59(1):60–64
Tong CC, Ko EC, Sung MW et al (2012) Phase II trial of concurrent sunitinib and image-guided radiotherapy for oligometastases. PLoS One 7(6):e36979
Torre LA, Bray F, Siegel RL et al (2015) Global cancer statistics, 2012. Cancer J Clin 65(2):87–108
Tree AC, Khoo VS, Eeles RA et al (2013) Stereotactic body radiotherapy for oligometastases. Lancet Oncol 14(1):e28–e37
Truman JP, García-Barros M, Kaag M et al (2010) Endothelial membrane remodeling is obligate for anti-angiogenic radiosensitization during tumor radiosurgery. PLoS One 5(8):e12310
Tse RV, Hawkins M, Lockwood G et al (2008) Phase I study of individualized stereotactic body radiotherapy for hepatocellular carcinoma and intrahepatic cholangiocarcinoma. J Clin Oncol 26(4):657–664
Tunio MA, Hashmi A, Rafi M et al (2010) Need for a new trial to evaluate postoperative radiotherapy in renal cell carcinoma: a meta-analysis of randomized controlled trials. Ann Oncol 21(9):1839–1845
Unger KR, Lominska CE, Deeken JF et al (2010) Fractionated stereotactic radiosurgery for reirradiation of head-and-neck cancer. Int J Radiat Oncol Biol Phys 77(5):1411–1419
Vansteenkiste J, De Ruysscher D, Eberhardt WE et al (2013) Early and locally advanced non-small-cell lung cancer (NSCLC): ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol 24(Suppl 6):vi89–vi98
Vansteenkiste J, Crino L, Dooms C et al (2014) 2nd ESMO consensus conference on lung cancer: early-stage non-small-cell lung cancer consensus on diagnosis, treatment and follow-up. Ann Oncol 25(8):1462–1474
Vargo JA, Wegner RE, Heron DE et al (2012) Stereotactic body radiation therapy for locally recurrent, previously irradiated nonsquamous cell cancers of the head and neck. Head Neck 34(8):1153–1161
Vargo JA, Ferris RL, Clump DA et al (2014a) Stereotactic body radiotherapy as primary treatment for elderly patients with medically inoperable head and neck cancer. Front Oncol 4:214
Vargo JA, Heron D, Ferris RL et al (2014b) Examining tumor control and toxicity after stereotactic body radiotherapy in locally recurrent previously irradiated head and neck cancers: implications of treatment duration and tumor volume. Head Neck 36(9):1349–1355
Vargo JA, Ferris RL, Ohr J et al (2015) A prospective phase 2 trial of reirradiation with stereotactic body radiation therapy plus cetuximab in patients with previously irradiated recurrent squamous cell carcinoma of the head and neck. Int J Radiat Oncol Biol Phys 91(3):480–488
Vedam SS, Keall PJ, Kini VR et al (2001) Determining parameters for respiration-gated radiotherapy. Med Phys 28(10):2139–2146
Vedam SS, Kini VR, Keall PJ et al (2003) Quantifying the predictability of diaphragm motion during respiration with a noninvasive external marker. Med Phys 30(4):505–513
Verstegen NE, Lagerwaard FJ, Haasbeek CJ et al (2011) Outcomes of stereotactic ablative radiotherapy following a clinical diagnosis of stage I NSCLC: comparison with a contemporaneous cohort with pathologically proven disease. Radiother Oncol 101(2):250–254
Verstegen N, Oosterhuis J, Palma D et al (2013) Stage I–II non-small-cell lung cancer treated using either stereotactic ablative radiotherapy (SABR) or lobectomy by video-assisted thoracoscopic surgery (VATS): outcomes of a propensity score-matched analysis. Ann Oncol 24(6):1543–1548
Viani GA, Stefano EJ, Afonso SL (2009) Higher-than-conventional radiation doses in localized prostate cancer treatment: a meta-analysis of randomized, controlled trials. Int J Radiat Oncol Biol Phys 74(5):1405–1418
Vickress J, Lock M, Lo S et al (2017) A multivariable model to predict survival for patients with hepatic carcinoma or liver metastasis receiving radiotherapy. Future Oncol 13(1):19–30
Voynov G, Heron DE, Burton S et al (2006) Frameless stereotactic radiosurgery for recurrent head and neck carcinoma. Technol Cancer Res Treat 5(5):529–535
Wahidi MM, Govert JA, Goudar RK et al (2007) Evidence for the treatment of patients with pulmonary nodules: when is it lung cancer?: ACCP evidence-based clinical practice guidelines. Chest J 132(3_suppl):94S–107S
Walsh L, Stanfield JL, Cho LC et al (2006) Efficacy of ablative high-dose-per-fraction radiation for implanted human renal cell cancer in a nude mouse model. Eur Urol 50(4):795–800. discussion 800
Wang XS, Rhines LD, Shiu AS et al (2012) Stereotactic body radiation therapy for management of spinal metastases in patients without spinal cord compression: a phase 1-2 trial. Lancet Oncol 13(4):395–402
Wang K, Heron DE, Clump DA et al (2013) Target delineation in stereotactic body radiation therapy for recurrent head and neck cancer: a retrospective analysis of the impact of margins and automated PET-CT segmentation. Radiother Oncol 106(1):90–95
Wang YJ, Han TT, Xue JX et al (2014) Stereotactic gamma-ray body radiation therapy for asynchronous bilateral renal cell carcinoma. Radiol Med 119(11):878–883
Wang CJ, Cai X, Kim DW et al (2016) The effect of stereotactic ablative radiotherapy on time to change of systemic therapy in extra-cranial renal cell carcinoma metastases. J Clin Oncol (Meeting Abstracts) 34(2 suppl):533
van der Werf-Messing B (1973) Proceedings: carcinoma of the kidney. Cancer 32(5):1056–1061
Wersall PJ, Blomgren H, Lax I et al (2005) Extracranial stereotactic radiotherapy for primary and metastatic renal cell carcinoma. Radiother Oncol 77(1):88–95
Winter JD, Wong R, Swaminath A et al (2015) Accuracy of robotic radiosurgical liver treatment throughout the respiratory cycle. Int J Radiat Oncol Biol Phys 93(4):916–924
Wong P, Houghton P, Kirsch DG et al. Combining targeted agents with modern radiotherapy in soft tissue sarcomas. J Natl Cancer Inst 2014; 106(11): doi:10.1093/jnci/dju329.
Yamada Y, Laufer I, Cox BW et al (2013) Preliminary results of high-dose single-fraction radiotherapy for the management of chordomas of the spine and sacrum. Neurosurgery 73(4):673–680. discussion 680
Yamamoto T et al (2016) Renal atrophy after stereotactic body radiotherapy for renal cell carcinoma. Radiat Oncol 11(1):72
Yamazaki H, Ogita M, Himei K et al (2015) Carotid blowout syndrome in pharyngeal cancer patients treated by hypofractionated stereotactic re-irradiation using CyberKnife: a multi-institutional matched-cohort analysis. Radiother Oncol 115(1):67–71
Yang JC, Sherry RM, Steinberg SM et al (2003) Randomized study of high-dose and low-dose interleukin-2 in patients with metastatic renal cancer. J Clin Oncol 21(16):3127–3132
Yang W, Fraass BA, Reznik R et al (2014) Adequacy of inhale/exhale breathhold CT based ITV margins and image-guided registration for free-breathing pancreas and liver SBRT. Radiat Oncol 9(1):11
Yao HH, Hong MK, Corcoran NM et al (2014) Advances in local and ablative treatment of oligometastasis in prostate cancer. Asia Pac J Clin Oncol 10(4):308–321
Yazici G, Sanli TY, Cengiz M et al (2013) A simple strategy to decrease fatal carotid blowout syndrome after stereotactic body reirradiaton for recurrent head and neck cancers. Radiat Oncol (London, England) 8:242-717X-8-242
Yen CP, Monteith SJ, Nguyen JH et al (2010) Gamma knife surgery for arteriovenous malformations in children: clinical article. J Neurosurg 6(5):426–434
Yeoh EE, Botten RJ, Butters J et al (2011) Hypofractionated versus conventionally fractionated radiotherapy for prostate carcinoma: final results of phase III randomized trial. Int J Radiat Oncol Biol Phys 81(5):1271–1278
Yoon SM, Lim YS, Won HJ et al (2012) Radiotherapy plus transarterial chemoembolization for hepatocellular carcinoma invading the portal vein: long-term patient outcomes. Int J Radiat Oncol Biol Phys 82(5):2004–2011
Yu JB, Cramer LD, Herrin J et al (2014) Stereotactic body radiation therapy versus intensity-modulated radiation therapy for prostate cancer: comparison of toxicity. J Clin Oncol 32(12):1195–1201
Zelefsky MJ, Greco C, Motzer R et al (2012) Tumor control outcomes after hypofractionated and single-dose stereotactic image-guided intensity-modulated radiotherapy for extracranial metastases from renal cell carcinoma. Int J Radiat Oncol Biol Phys 82(5):1744–1748
Zeng ZC, Tang ZY, Fan J et al (2005) Radiation therapy for adrenal gland metastases from hepatocellular carcinoma. Jpn J Clin Oncol 35(2):61–67
Zhang HP, Takayama K, Su B et al (2011) Effect of sunitinib combined with ionizing radiation on endothelial cells. J Radiat Res 52(1):1–8
Zimetbaum P (2012) Antiarrhythmic drug therapy for atrial fibrillation. Circulation 125(2):381–389
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Kothari, G. et al. (2017). Stereotactic Body Radiotherapy. In: Trombetta, M., Pignol, JP., Montemaggi, P., Brady, L.W. (eds) Alternate Fractionation in Radiotherapy. Medical Radiology(). Springer, Cham. https://doi.org/10.1007/174_2017_38
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