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Reduced Normal Tissue Doses Through Advanced Technology

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Re-Irradiation: New Frontiers

Part of the book series: Medical Radiology ((Med Radiol Radiat Oncol))

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Abstract

Re-irradiation is probably the most challenging situation in radiotherapy because the radiation tolerance of the normal tissue is significantly reduced compared with the first treatment series. Results with traditional radiotherapy techniques have been disappointing because of the poor conformality of the dose distributions: radiation doses were either insufficiently low resulting in poor rates of tumor control or substantial toxicity was the consequence of high-dose re-irradiation. This chapter will focus on modern techniques of radiation treatment planning and delivery, which make improved sparing of the normal tissue possible. All techniques will be discussed in the context of re-irradiation and theoretical and clinical data supporting the use of these technologies will be presented. Palliative reirradiation to moderate doses might be feasible without using advanced technology. However, under many circumstances 2D or 3D conformal approaches cannot fulfill the required normal tissue constraints. The present chapter discusses the advantages and challenges associated with more complex planning and delivery methods.

The original version of this chapter was revised. An erratum to this chapter can be found at 10.1007/978-3-319-41825-4_78.

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Authors and Affiliations

  1. Department of Radiation Oncology, University Hospital Zurich, Zurich, Switzerland

    Matthias Guckenberger, Cedric Panje & Stephanie Tanadini-Lang

  2. Department of Radiation Oncology, Leopoldina Hospital Schweinfurt, Schweinfurt, Germany

    Reinhart A. Sweeney

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  1. Matthias Guckenberger
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  2. Reinhart A. Sweeney
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  3. Cedric Panje
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  4. Stephanie Tanadini-Lang
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Correspondence to Matthias Guckenberger .

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Editors and Affiliations

  1. Department of Oncology, University of Tromso and Nordland Hospital, Bodo, Norway

    Carsten Nieder

  2. University Medical Center Groningen, Groningen, The Netherlands

    Johannes Langendijk

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Guckenberger, M., Sweeney, R.A., Panje, C., Tanadini-Lang, S. (2016). Reduced Normal Tissue Doses Through Advanced Technology. In: Nieder, C., Langendijk, J. (eds) Re-Irradiation: New Frontiers. Medical Radiology(). Springer, Cham. https://doi.org/10.1007/174_2016_55

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