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Platelet-Derived Growth Factor in Heart Failure

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Heart Failure

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 243))

Abstract

Defective vascular and cardiomyocyte function are implicated in the development and progression of both heart failure with reduced and preserved ejection fraction. Any treatment option that augments these myocardial processes may therefore be of significant value. The platelet-derived growth factor (PDGF) family is involved in a wide range of growth processes and plays a key role in both regulating angiogenesis and mesenchymal cell development. Thus, PDGF may serve as a potent therapy for heart failure. While numerous animal studies have demonstrated beneficial cardiovascular effects of growth factor therapy, promising laboratory data has not yet translated to effective therapies. In this review, we outline the biological role of PDGF and summarize previous studies that have focused on the cardiovascular effects of normal PDGF signaling, administration of PDGF, and the effects of PDGF on stem cell therapy.

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Abbreviations

Ang-2:

Angiopoietin-2

CK-MB:

Creatine phosphokinase-myocardial band

FGF:

Basic fibroblast growth factor

HF:

Heart failure

HFpEF:

Heart failure with preserved ejection fraction

HSP:

Heat shock protein

IGF-1:

Insulin-like growth factor

LDH:

Lactate dehydrogenase

MAP:

Mitogen-activated protein

MEK:

Mitogen-activated ERK-activating kinase

PDGF:

Platelet-derived growth factor

PKC:

Protein kinase C

PLC:

Phospholipase C

VEGF:

Vascular endothelial growth factor

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Acknowledgments

Funding for this manuscript was provided by a summer research grant from the Department of Dermatology at Stony Brook University Medical Center.

Conflict of Interest JM and JB report no conflict of interest. RC is the co-discoverer of a fibronectin-derived peptide that binds and enhances the activity of PDGF-BB and is the founder of NeoMatrix Therapeutics, which is developing the peptide to prevent burn injury progression, speed healing, and reduce scarring.

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Authors and Affiliations

  1. School of Medicine, Stony Brook University, Stony Brook, NY, 11794-8165, USA

    John Medamana

  2. Department of Dermatology, Health Science Center T16-060, Stony Brook University, Stony Brook, NY, 11794-8165, USA

    Richard A. Clark

  3. Division of Cardiology, Health Science Center T16-080, Stony Brook University, Stony Brook, NY, 11794-8165, USA

    Javed Butler

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  1. John Medamana
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  2. Richard A. Clark
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  3. Javed Butler
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Corresponding authors

Correspondence to Richard A. Clark or Javed Butler .

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Editors and Affiliations

  1. Klinik für Kardiologie und Angiologie, Medizinische Hochschule Hannover Klinik für Kardiologie und Angiologie, Hannover, Niedersachsen, Germany

    Johann Bauersachs

  2. Heart Institute, Stony Brook University , Stony Brook, New York, USA

    Javed Butler

  3. Heart and Lung Diseases, Bayer Pharma Aktiengesellschaft Heart and Lung Diseases, Wuppertal, Nordrhein-Westfalen, Germany

    Peter Sandner

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Medamana, J., Clark, R.A., Butler, J. (2016). Platelet-Derived Growth Factor in Heart Failure. In: Bauersachs, J., Butler, J., Sandner, P. (eds) Heart Failure. Handbook of Experimental Pharmacology, vol 243. Springer, Cham. https://doi.org/10.1007/164_2016_80

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