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Fluorous Organic Hybrid Solvents for Non-Fluorous Organic Synthesis

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Fluorous Chemistry

Part of the book series: Topics in Current Chemistry ((TOPCURRCHEM,volume 308))

Abstract

The rapid progress in fluorous chemistry shed the light on the use of fluorous-organic hybrid solvents for fluorous reactions; however, these hybrid solvents also have good potentials as solvents for ordinary organic synthesis. This chapter will survey the state of the art of the fluorous organic hybrid solvents as green substitutes for traditional organic solvents.

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Abbreviations

AIBN:

2,2′-Azobisisobutyronitrile

Bmim:

Butylmethylimidazolium

BTF:

Benzotrifluoride (trifluoromethylbenzene α,α,α−trifluorotoluene)

DCE:

1,2-Dichloroethane

ET value:

A scale for polarity of a solvent based on negatively solvatochromism of the pyridinium betaine dye

FC-72:

Perfluorohexanes

F-SPE:

Fluorous solid phase extraction

mpg-C3N4 :

Mesoporous carbon nitride

NHPI:

N-Hydroxyphthalimide

NBS:

N-Bromosuccinimide

PCC:

Pyridinium chlorochromate

PDC:

Pyridinium dichromate

PDE 4:

Phosphodiesterase 4

PFD:

Perfluorodecalin

SPC:

Sodium percarbonate

S-PTPA:

N-Phthaloyl-(S)-phenylalaninate

TBPA:

Tris(p-bromophenyl)aminium hexachloroantimonate

TEA:

Triethylamine

TFA:

Trifluoroacetic acid

TfOH:

Trifluoromethanesulfonic acid

TMS:

Trimethylsilyl

TPP:

Tetraphenylporphyrin

TTMSS:

Tris(trimethylsilyl)silane

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Authors and Affiliations

  1. Department of Chemistry, Graduate School of Science, Osaka Prefecture University, Sakai, Osaka, 599-8531, Japan

    Hiroshi Matsubara & Ilhyong Ryu

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  1. Hiroshi Matsubara
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  2. Ilhyong Ryu
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Correspondence to Ilhyong Ryu .

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Editors and Affiliations

  1. , Department of Biology and Chemistry, City University of Hong Kong, Tat Chee Avenue, Kowloon, China, People's Republic

    István T. Horváth

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Matsubara, H., Ryu, I. (2011). Fluorous Organic Hybrid Solvents for Non-Fluorous Organic Synthesis. In: Horváth, I. (eds) Fluorous Chemistry. Topics in Current Chemistry, vol 308. Springer, Berlin, Heidelberg. https://doi.org/10.1007/128_2011_250

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