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Automatic Control of Bioprocesses

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Measurement, Monitoring, Modelling and Control of Bioprocesses

Part of the book series: Advances in Biochemical Engineering/Biotechnology ((ABE,volume 132))

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Abbreviations

ANN:

Artificial neural network

CER:

Carbon dioxide evolution rate

C feed :

Substrate concentration in feed flow

CPR:

Carbon dioxide production rate

DO:

Dissolved oxygen

e(t):

Control deviation at time t

EKF:

Extended Kalman filter

FIA:

Flow injection analysis

F0(t):

Feeding rate

Fb(t):

Feeding rate due to feedback part

GC:

Gas chromatography

HCDC:

High-cell-density cultivation

K :

PID controller parameter matrix

K d :

PID controller parameter, derivative part

K i :

PID controller parameter, integral part

K L a :

Oxygen transfer coefficient

K p :

PID controller parameter, proportional part

LLM:

Local linear model

LoLiMoT:

Local linear model tree

m :

Substrate consumption due to cell maintenance

MIMO:

Multiple-input multiple-output

MISO:

Multiple-input single-output

MPC:

Model predictive controller

NMPC:

Nonlinear model predictive controller

ORP:

Oxidation–reduction potential

OTR:

Oxygen transfer rate

OUR:

Oxygen uptake rate

PID:

Proportional–integral–derivative

r DO :

Specific oxygen consumption rate

r DO X t :

Oxygen consumption rate

SISO:

Single-input single-output

t :

Time

u(t):

Control action at time t

V :

Cultivation volume

V 0 :

Initial volume

V head :

Volume of head space

X :

Biomass

x(t),x:

Input values (measurement)

X 0 :

Initial biomass

Y XS :

Yield factor for biomass formation

μ :

Specific growth rate

μB(X):

Membership function of a fuzzy logic controller

μ sp :

Set-point of specific growth rate

τ :

Integration variable

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Authors and Affiliations

  1. Process Analytics and Cereal Technology, Institute of Food Science and Biotechnology, University of Hohenheim, Garbenstr. 23, 70599, Stuttgart, Germany

    Marc Stanke & Bernd Hitzmann

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  1. Marc Stanke
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  2. Bernd Hitzmann
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Correspondence to Bernd Hitzmann .

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Editors and Affiliations

  1. , Division of Biotechnology, Linköping University, Campus, Linköping, 581 83, Sweden

    Carl-Fredrik Mandenius

  2. Dept.Biochemival Engineering, University College London, Torrington Place, London, WC1E 7JE, United Kingdom

    Nigel J Titchener-Hooker

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Stanke, M., Hitzmann, B. (2012). Automatic Control of Bioprocesses. In: Mandenius, CF., Titchener-Hooker, N. (eds) Measurement, Monitoring, Modelling and Control of Bioprocesses. Advances in Biochemical Engineering/Biotechnology, vol 132. Springer, Berlin, Heidelberg. https://doi.org/10.1007/10_2012_167

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