Abstract
Biologists have long recognized that the transport of ions and of neutral species across cell membranes is central to physiological function. Cells rely on their biomembranes, which separate the cytoplasm from the extracellular medium, to maintain the two electrolytes at very different composition. Specialized molecules, essentially biological nanodevices, have evolved to selectively control the movement of all the major physiological species. As should be clear, there have to be at least two distinct modes of transport. To maintain the disequilibrium, there must be molecular assemblies that drive ions and other permeable species against their electrochemical potential gradients. Such devices require energy input, typically coupling a vectorial pump with a chemical reaction, the dephosphorylation of ATP (adenosine triphosphate). These enzymes (biochemical catalysts) control highly concerted, and relatively slow, process, with turnovers of ≫ 100 s¡ 1.
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Jordan, P.C. (2007). Ion Channels, from Fantasy to Fact in Fifty Years1 . In: Chung, SH., Andersen, O.S., Krishnamurthy, V. (eds) Biological Membrane Ion Channels. Biological And Medical Physics Biomedical Engineering. Springer, New York, NY. https://doi.org/10.1007/0-387-68919-2_1
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