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Immunity and Autoimmunity Induced by Polyomaviruses

Clinical, Experimental and Theoretical Aspects

  • Chapter
Polyomaviruses and Human Diseases

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 577))

Abstract

In this chapter, polyomaviruses will be presented in an immunological context. Principal observations will be discussed to elucidate humoral and cellular immune responses to different species of the polyomaviruses and to individual viral structural and regulatory proteins. The role of immune responses towards the viruses or their proteins in context of protection against polyomavirus induced tumors will be described. One central aspect of this presentation is the ability of polyomaviruses, and particularly large T-antigen, to terminate immunological tolerance to nucleosomes, DNA and histones. Thus, in the present chapter we will focus on clinical, experimental and theoretical aspects of the immunity to polyomaviruses.

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  1. University of Trosm¿, Trosm¿, Norway

    Ole Petter Rekvig Ph.D., Signy Bendiksen Ph.D. & Ugo Moens Ph.D.

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    Nasimul Ahsan M.D., FACP

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Rekvig, O.P., Bendiksen, S., Moens, U. (2006). Immunity and Autoimmunity Induced by Polyomaviruses. In: Ahsan, N. (eds) Polyomaviruses and Human Diseases. Advances in Experimental Medicine and Biology, vol 577. Springer, New York, NY. https://doi.org/10.1007/0-387-32957-9_9

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