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Histopathology of EAE

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Experimental Models of Multiple Sclerosis

Abstract

This chapter reviews the histological structure of the normal central nervous system and the basic pathology of inflammation and demyelination of this tissue. An outline of the pathogenesis of experimental autoimmune encephalomyelitis (EAE) is given and pathology of multiple sclerosis is reviewed. The limitations of EAE as a model for multiple sclerosis are discussed. The approach to histopathological assessment of the lesions of EAE is outlined, including collection and processing of appropriate samples and a review of grading systems that have been used to quantify the histopathological changes. The specific histopathological features of EAE are described with reference to selected model systems including the SJL/J, C57B1/6 and NOD mouse, the Lewis rat, rhesus monkey and marmoset.

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Authors and Affiliations

  1. Department of Pathology & Microbiology, School of Veterinary Science, University of Bristol, Langford, BS40 5DU, UK

    Michael J. Day

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  1. Michael J. Day
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Editor information

Editors and Affiliations

  1. Weill Medical College of Cornell University, New York

    Ehud Lavi

  2. Queen’s Medical Centre, University Hospital, Nottingham, UK

    Cris S. Constantinescu

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© 2005 Springer Science+Business Media, Inc.

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Day, M.J. (2005). Histopathology of EAE. In: Lavi, E., Constantinescu, C.S. (eds) Experimental Models of Multiple Sclerosis. Springer, Boston, MA. https://doi.org/10.1007/0-387-25518-4_3

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