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Mechanisms of the demyelination process and its modeling

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Abstract

Neuropathological diseases involving destruction of the myelin sheath of nerve fibers as a leading pathogenetic process are very extensively distributed. In spite of numerous studies in this field, mechanisms of myelin destruction remain in many aspects unsatisfactorily interpreted. Investigation of pathogenesis of demyelinating disease, especially on the molecular and genetic levels, makes necessary the improvement of the existing approaches and, in particular, development of adequate models of such diseases. In our review, we describe modern notions on the structure of myelin sheaths and some mechanisms of their destruction, as well as some models, which allow experimenters to make more perfect our knowledge of the mechanisms of demyelinating diseases, both on the cellular level and on the level of an integral organism.

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  1. Bogomolets Institute of Physiology, National Academy of Sciences of Ukraine, Kyiv, Ukraine

    T. A. Pivneva, E. V. Kolotoushkina & N. A. Mel’nik

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Pivneva, T.A., Kolotoushkina, E.V. & Mel’nik, N.A. Mechanisms of the demyelination process and its modeling. Neurophysiology 31, 403–412 (1999). https://doi.org/10.1007/BF02515144

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