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The Status of Serotonin-Selective Pharmacotherapy in the Treatment of Alcohol Dependence

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Recent Developments in Alcoholism

Part of the book series: Recent Developments in Alcoholism ((RDIA,volume 16))

Abstract

Research performed during the past 20 years has shown that serotonin (5-hydroxytrypt-amine; 5-HT) neurotransmission is related to alcohol dependence. Both theoretical and empirical research have supported the idea that alcohol dependence is a chronic disease and that, in addition, biological vulnerabilities contribute to the pathogenesis of alcohol dependence. Preclinical studies have consistently demonstrated that there is a relationship between 5-HT function and alcohol consumption. Furthermore, there is evidence building that lends support for the existence of distinct alcoholic subtypes that may be differentiated by the type or complexity of their 5-HT dysfunction. Beyond excessive drinking, behaviors that are indicators of 5-HT dysregulation are depression, anxiety, impulsiveness, and early-onset problem drinking. This chapter will discuss the usefulness of 5-HT-selective pharmacotherapy in treating alcohol dependence and will provide both historical and current perspectives on its use.

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References

  • Anthenelli, R.M., & Maxwell, R.A. (2000). Cigarette smoking decreases the prolactin response to serotonergic stimulation in subgroups of alcoholics and controls. Alcoholism: Clinical and Experimental Research 24, 987–995.

    Google Scholar 

  • Ã…sberg, M., Schalling, D., & Träskman-Bendz, L. (1987). Psychobiology of suicide, impulsivity, and related phenomena. In H.Y. Meltzer (ed.), Psychopharmacology: The Third Generation of Progress. New York: Raven Press, pp. 665–668.

    Google Scholar 

  • Babor, T.F., Dolinsky, Z., Rounsaville, B., & Jaffe, J. (1988). Unitary versus multidimensional models of alcoholism treatment outcome: An empirical study. Journal of Studies on Alcohol 49, 167–177.

    PubMed  Google Scholar 

  • Babor, T.F., Dolinsky, Z., Meyer, R.E., Hesselbrock, M., Hofmann, M., & Tennen, H. (1992a). Types of alcoholics: Concurrent and predictive validity of some common classification schemes. British Journal of Addiction 87, 1415–1431.

    PubMed  Google Scholar 

  • Babor, T.F., Hofmann, M., Del Boca, F.K., Hesselbrock, V., Meyer, R.E., Dolinsky, Z.S., & Rounsaville, B. (1992b). Types of alcoholics, 1: Evidence for an empirically derived typology based on indicators of vulnerability and severity. Archives of General Psychiatry 49, 599–608.

    PubMed  Google Scholar 

  • Ballenger, J., Goodwin, F., Major, L., & Brown, G. (1979). Alcohol and central serotonin metabolism in man. Archives of General Psychiatry 36, 224–227.

    PubMed  Google Scholar 

  • Balldin, J., Berggren, U., Engel, J., Eriksson, M., Hard, E., & Soderpalm, B. (1994). Effect of citalopram on alcohol intake in heavy drinkers. Alcoholism: Clinical and Experimental Research 18, 1133–1136.

    Google Scholar 

  • Banki, C. (1981). Factors influencing monoamine metabolites and tryptophan in patients with alcohol dependence. Journal of Neural Transmission 50, 89–101.

    Article  PubMed  Google Scholar 

  • Brown, G.L., Goodwin, F.K., Ballenger, J.C., Goyer, P.F., & Major, L.F. (1979). Aggression in humans correlates with cerebrospinal fluid amine metabolites. Psychiatry Research 1, 131–139.

    Article  PubMed  Google Scholar 

  • Buydens-Branchey, L., Branchey, M.H., & Noumair, D. (1989). Age of alcoholism onset. I. Relationship to psychopathology. Archives of General Psychiatry 46, 225–230.

    PubMed  Google Scholar 

  • Buydens-Branchey, L., Branchey, M.H., Noumair, D., & Lieber, C.S. (1989). Age of alcoholism onset. II. Relationship to susceptibility to serotonin precursor availability. Archives of General Psychiatry 46, 231–236.

    PubMed  Google Scholar 

  • Carmichael, F., & Israel, Y. (1975). Effects of ethanol on neurotransmitter release by rat brain cortical slices. Journal of Pharmacology and Experimental Therapeutics 193, 824–834.

    PubMed  Google Scholar 

  • Cloninger, C.R. (1987). Neurogenetic adaptive mechanisms in alcoholism. Science 236, 410–416.

    PubMed  Google Scholar 

  • Coccaro, E.F., & Murphy, D.L. (eds.). (1990). Serotonin in Major Psychiatric Disorders. Washington, DC: American Psychiatric Press.

    Google Scholar 

  • Coccaro, E.F., Siever, L., Klar, H.M., Maurer, G., Cochrane, K., Cooper, T.B., Mohs, R.C., & Davis, K.L. (1989). Serotonergic studies in patients with affective and personality disorders: Correlates with suicidal and impulsive aggressive behavior. Archives of General Psychiatry 46, 587–599.

    PubMed  Google Scholar 

  • Collins, D.M., & Myers, R.D. (1987). Buspirone attenuates volitional alcohol intake in the chronically drinking monkey. Alcohol and Alcoholism 4, 49–56.

    Google Scholar 

  • Cornelius, J.R., Salloum, I.M., Ehler, J.G., Jarrett, P.J., Cornelius, M.D., Perel, J.M., Thase, M.E., & Black, A. (1997). Fluoxetine in depressed alcoholics: A double-blind, placebo-controlled trial. Archives of General Psychiatry 54, 700–705.

    PubMed  Google Scholar 

  • Eison, A.S., & Temple, D.L. (1986). Buspirone: Review of its pharmacology and current perspectives on its mechanism of action. American Journal of Medicine 80 (3B), 1–9.

    PubMed  Google Scholar 

  • Engel, J.A., Fahlke, C., Hard, E., Johannessen, K., Svensson, L., & Soderpalm, P. (1992). Serotonergic and dopaminergic involvement in ethanol intake. Clinical Neuropharmacology 15(Suppl 1), 64A–65A.

    PubMed  Google Scholar 

  • Farren, C.K., Ziedonis, D., Clare, A.W., Hammeedi, F.A., & Dinan, T.G. (1995). D-fenfluramine-induced prolactin responses in postwithdrawal alcoholics and controls. Alcoholism: Clinical and Experimental Research 19, 1578–1582.

    Google Scholar 

  • Fils-Aime, M.L., Eckardt, M.J., George, D.T., Brown, G.L., Mefford, I., & Linnoila, M. (1996). Early-onset alcoholics have lower cerebral spinal fluid 5-hydroxyindoleacetic acid levels than late-onset alcoholics. Archives of General Psychiatry 53, 211–216.

    PubMed  Google Scholar 

  • Gallant, D. (1993). Amethysic agents and adjunct behavioral therapy and psychotherapy. Alcoholism: Clinical and Experimental Research 17, 197–198.

    Google Scholar 

  • Gallant, D. (1999). Alcohol. In M. Galanter & H. Kleber (eds.), The American Psychiatric Press Textbook of Substance Abuse Treatment, 2nd ed. Washington: American Psychiatric Press, pp. 151–164.

    Google Scholar 

  • George, D.T., Benkelfat, C., Rawlings, R.R., Eckardt, M.J., Phillips, M.J., Nutt, D.J., Wynne, D., Murphy, D.L., & Linnoila, M. (1997). Behavioral and neuroendocrine responses to m-chlorophenylpiperazine in subtypes of alcoholics and in healthy comparison subjects. American Journal of Psychiatry 154, 81–87.

    PubMed  Google Scholar 

  • Gorelick, D.A. (1989). Serotonin reuptake blockers and the treatment of alcoholism. In M. Galanter (ed.), Recent Developments in Alcoholism: Vol. 7. Treatment Research. New York: Plenum Press, pp. 267–281.

    Google Scholar 

  • Gorelick, D.A., & Paredes, A. (1992). Effect of fluoxetine on alcohol consumption in male alcoholics. Alcoholism: Clinicaland Experimental Research 16, 261–265.

    Google Scholar 

  • Grant, B., & Hartford, T. (1995). Comorbidity between DSM-IV alcohol use disorders and major depression: Results of a national survey. Drug and Alcohol Dependence 39, 197–206.

    PubMed  Google Scholar 

  • Heinz, A., Mann, K., Weinberger, D.R., & Goldman, D. (2001). Serotonergic dysfunction, negative mood states, and response to alcohol. Alcoholism: Clinical and Experimental Research 25, 487–495.

    Google Scholar 

  • Higley, J., Hasert, M., Suomi, S., & Linnoila, M. (1998). The serotonin reuptake inhibitor sertraline reduces excessive alcohol consumption in nonhuman primates: Effect of stress. Neuropsychopharmacology 18, 431–443.

    PubMed  Google Scholar 

  • Imperato, A., & DiChiara, G. (1986). Preferential stimulation of dopamine release in the nucleus accumbens of freely moving rats by ethanol. Journal of Pharmacology and Experimental Therapeutics 239, 219–228.

    PubMed  Google Scholar 

  • Johnson, B.A. (2000). Serotonergic agents and alcoholism treatment: Rebirth of the subtype concept—a hypothesis. Alcoholism: Clinical and Experimental Research 24, 1597–1601.

    Google Scholar 

  • Johnson, B.A., Roache, J.D., Javors, M.A., DiClemente, C.C., Cloninger, C.R., Prihoda, T.J., Bordnick, P.S., Ait-Daoud, N., & Hensler, J. (2000). Odansetron for reduction of drinking among biologically predisposed alcoholic patients: A randomized controlled trial. Journal of the American Medical Association 284(9), 963–971.

    PubMed  Google Scholar 

  • Kabel, D., & Petty, F. (1996). Adouble-blind study of fluoxetine in severe alcohol dependence: Adjunctive therapy during and after inpatient treatment. Alcoholism: Clinical and Experimental Research 20, 780–784.

    Google Scholar 

  • Kessler, R.C., Nelson, C.B., McGonagle, K.A., Edlund, M.J., Frank, R.G., & Leaf, P.J. (1996). The epidemiology of co-occurring addictive and mental disorders: Implications for prevention and service utilization. American Journal of Orthopsychiatry 66, 17–31.

    PubMed  Google Scholar 

  • Knapp, D.J., & Pohorecky, L.A. (1992). Zacopride, a 5-HT3 receptor antagonist, reduces voluntary ethanol consumption in rats. Pharmacology, Biochemistry and Behavior 41, 847–850.

    Article  Google Scholar 

  • Koob, G., & Roberts, A. (1999). Brain reward circuits in alcoholism. CNS Spectrums 4, 23–37.

    Google Scholar 

  • Koob, G., & Weiss, F. (1992). Neuropharmacology of cocaine andethanol dependence. Recent Developments in Alcoholism 10, 201–233.

    PubMed  Google Scholar 

  • Kranzler, H.R. (2000). Pharmacotherapy of alcoholism: Gaps in knowledge and opportunities for research. Alcohol and Alcoholism 35, 537–547.

    Article  PubMed  Google Scholar 

  • Kranzler, H.R., & Anton R.F. (1994). Implications of recent neuropsychopharmacologic research for understanding the etiology and development of alcoholism. Journal of Consulting and Clinical Psychology 62, 1116–1126.

    Article  PubMed  Google Scholar 

  • Kranzler, H.R., Burleson, J.A., Del Boca, F.K., Babor, T.F., Korner, P., Brown, J., & Bohn, M.J. (1994). Buspirone treatment of anxious alcoholics: A placebo-controlled trial. Archives of General Psychiatry 51(9), 720–731.

    PubMed  Google Scholar 

  • Kranzler, H.R., Burleson, J.A., Korner, P., Del Boca, F.K., Bohn, M.J., Brown, J., & Liebowitz, N. (1995). Placebo-controlled trial of fluoxetine as an adjunct to relapse prevention in alcoholics. American Journal of Psychiatry 152(3), 391–397.

    PubMed  Google Scholar 

  • Kranzler, H.R., Burleson, J.A., Brown, J., & Babor, T.F. (1996). Fluoxetine treatment seems to reduce the beneficial effects of cognitive-behavioral therapy in type B alcoholics. Alcoholism: Clinical and Experimental Research 20, 1534–1541.

    Google Scholar 

  • Krystal, J.H., Webb, E., Cooney, N.L., Kranzler, H.R., & Charney, D.S. (1994). Specificity of ethanol-like effects elicited by Serotonergic and noradrenergic mechanisms. Archives of General Psychiatry 51, 898–911.

    PubMed  Google Scholar 

  • Lee, M.A., & Meltzer, H.Y. (1991). Neuroendocrine responses to Serotonergic agents in alcoholics. Biological Psychiatry 30, 1017–1030.

    Article  PubMed  Google Scholar 

  • Lejoyeux, M. (1996). Use of serotonin (5-hydroxytryptamine) reuptake inhibitors in the treatment of alcoholism. Alcohol and Alcoholism 1, 69–75.

    Google Scholar 

  • Linnoila, M., Virkkunen, M., Scheinin, M., Nuutila, A., Rimon, R., & Goodwin, F.K. (1983). Low cerebrospinal fluid 5-Hydroxyindoleacetic acid concentration differentiates impulsive from nonimpulsive violent behavior. Life Sciences 33, 2609–2614.

    Article  PubMed  Google Scholar 

  • Lovinger, D. (1991). Ethanolpotentiation of 5-HT3 receptor-mediated ion current in NCB-20 neuroblastoma cells. Neuroscience Letters 122, 57–60.

    Article  PubMed  Google Scholar 

  • Maes, M., & Meltzer, H. (1995). The serotonin hypothesis of major depression. In A.C. Bloom & D.J. Kupfer (eds.), Psychopharmacology: The Fourth Generation of Progress. New York: Raven Press, pp. 933–944.

    Google Scholar 

  • Malcolm, R., Anton, R.F., Randall, D.L., Johnston, A., Brady, K., & Thevos, A. (1992). A placebo-controlled trial of buspirone in anxious inpatient alcoholics. Alcoholism: Clinical and Experimental Research 16, 1007–1013.

    Google Scholar 

  • Marlatt, G.A. (1985). Relapse prevention: Theoretical rationale and overview of the model. In G.A. Marlatt & J.R. Gordon (eds.), Relapse Prevention. New York: Guilford, pp. 3–70.

    Google Scholar 

  • McGrath, P. Fluoxetine for the treatment of alcoholism and depression. In R. Litten (Chair), Does 5-HT pharmacotherapy have a role in alcohol treatment? Symposium conducted at the Annual Meeting of the Research Society on Alcoholism, Hilton Head, SC, June 1998.

    Google Scholar 

  • McLellan, A.T., Lewis, D.C., O’Brien, C.P., & Kleber, H.D. (2000). Drug dependence, a chronic medical illness: Implications for treatment, insurance, and outcomes evaluation. Journal of the American Medical Association 284(13), 1689–1695.

    Article  PubMed  Google Scholar 

  • Mereau, G., Fadda, F., & Gessa, G. (1984). Ethanol stimulates the firing rate of nigral dopaminergic neurons in unanesthetized rats. Brain Research 292, 63–69.

    Google Scholar 

  • Moak, D.H., Voronin, K.E., Latham, P.K., & Anton, R.F. (2001). A double-blind placebo-controlled treatment study of sertraline in depressed alcoholics: Preliminary analysis. Alcoholism: Clinical and Experimental Research 25, 94A.

    Google Scholar 

  • Moeller, F.G., Dougherty, D.M., Swann A.C., Collins, D., Davis, C.M., & Cherek, D.R. (1996). Tryptophan depletion and aggressive responding in healthy males. Psychopharmacology 126, 97–103.

    Article  PubMed  Google Scholar 

  • Myers, R., & Melchior, C.L. (1977). Alcohol and alcoholism: Role of serotonin. In W.B. Essman (ed.), Serotonin in Health and Disease: Vol. 2. Physiological Regulation and Pharmacological Action. New York: Spectrum, pp. 373–430.

    Google Scholar 

  • Naranjo, C.A., & Knoke, D.M. (2001). The role of selective serotonin reuptake inhibitors in reducing alcohol consumption. Journal of Clinical Psychiatry 62(Suppl 20), 18–25.

    PubMed  Google Scholar 

  • Naranjo, C.A., Sellers, E.M., Roach, C.A., Woodley, D.V., Sanchez-Craig, M., & Sykora, K. (1984). Zimelidine-induced variations in alcohol intake by nondepressed heavy drinkers. Clinical Pharmacology & Therapeutics 35, 374–381.

    Article  Google Scholar 

  • Naranjo, C.A., Sellers, E.M., & Lawrin, M. (1986). Modulation of ethanol intake by serotonin uptake inhibitors. Journal of Clinical Psychiatry 47(Suppl 4), 16–22.

    PubMed  Google Scholar 

  • Naranjo, C.A., Sellers, E.M., Sullivan, J.T., Woodley, D.V., Kadlec, K., & Sykora, K. (1987). The serotonin uptake inhibitor citalopram attenuates ethanol intake. Clinical Pharmacology & Therapeutics 41, 266–274.

    Article  Google Scholar 

  • Naranjo, C.A., Sullivan, J.T., Kadlec, K.E., Woodley-Remus, D.V., Kennedy, G., & Sellers, E.M. (1989). Differential effects of viqualine on alcohol intake and other consummatory behaviors. Clinical Pharmacology & Therapeutics 46, 301–309.

    Article  Google Scholar 

  • Naranjo, C.A., Kadlec, K.E., Sanhueza, P., Woodley-Remus, D., & Sellers, E.M. (1990). Fluoxetine differentially alters alcohol intake and other consummatory behaviors in problem drinkers. Clinical Pharmacology & Therapeutics 47, 490–498.

    Article  Google Scholar 

  • Pandey, S., Lumeng, L., & Li, T. (1996). 5HT-2C receptors and 5HT-2C receptor-mediated phosphoinositide hydrolysis in the brain of alcohol-preferring and alcohol-non-preferring rats. Alcoholism: Clinical and Experimental Research 20, 1038–1042.

    Google Scholar 

  • Pettinati, H.M. (1996). Use of serotonin selective pharmacotherapy in the treatment of alcohol dependence. Alcoholism: Clinical and Experimental Research 20(7, Suppl), 23A–29A.

    Google Scholar 

  • Pettinati, H.M. (2001). The use of selective serotonin reuptake inhibitors in treating alcoholic subtypes. Journal of Clinical Psychiatry 62(Suppl 20), 26–31.

    PubMed  Google Scholar 

  • Pettinati, H.M., Oslin, D., & Decker, K. (2000a). Role of serotonin and serotonin-selective pharmacotherapy in alcohol dependence. CNS Spectrums 5(2), 33–46.

    PubMed  Google Scholar 

  • Pettinati, H.M., Rukstalis, M.R., Luck, G.J., Volpicelli, J.R., & O’Brien, C.P. (2000b). Gender and psychiatric comorbidity: Impact on clinical presentation of alcohol dependence. American Journal on Addictions 9, 242–252.

    PubMed  Google Scholar 

  • Pettinati, H.M., Volpicelli, J.R., Kranzler, H.R., Luck, G., Rukstalis, M.R., & Cnaan, A. (2000c). Sertraline treatment for alcohol dependence: Interactive effects of medication and subtype. Alcoholism: Clinical and Experimental Research 24(7), 1041–1049.

    Google Scholar 

  • Pettinati, H.M., Volpicelli, J.R., Luck, G., Kranzler, H.R., Rukstalis, M.R., & Cnaan, A. (2001). Double-blind clinical trial of sertraline treatment for alcohol dependence. Journal of Clinical Psychopharmacology 21(2), 143–153.

    Article  PubMed  Google Scholar 

  • Pietraszek, M.H., Urano, T., Sumioshi, K., Serizawa, K., Takahashi, S., Takada, Y., & Takada, A. (1991). Alcohol-induced depression: Involvement of serotonin. Alcohol and Alcoholism 26(2), 155–159.

    PubMed  Google Scholar 

  • Privette, T.H., Hornsby, R.I., & Myers, R.D. (1988). Buspirone alters alcohol drinking induced in rats by tetrahydropapaveroline injected into brain monoaminergic pathways. Alcohol 5, 147–152.

    Article  PubMed  Google Scholar 

  • Regier, D.A., Farmer, M.E., Rae, D.S., Locke, B.Z., Keith, S.J., Judd, L.L., & Goodwin, F.K. (1990). Comorbidity of mental disorders with alcohol and other drug abuse: Results from the Epidemiologic Catchment Area (ECA) study. Journal of the American Medical Association 264, 2511–2518.

    Article  PubMed  Google Scholar 

  • Roberts, A.J., McArthur, R.A., Hull, E.E., Post, C., & Koob, G.F. (1998). Effects of amperozide, 8-OH-DPAT, and FG5974 on operant responding for ethanol. Psychopharmacology 137, 25–32.

    Article  PubMed  Google Scholar 

  • Roy, A. (1998). Placebo-controlled study of sertraline in depressed recently abstinent alcoholics. Biological Psychiatry 44, 633–637.

    PubMed  Google Scholar 

  • Roy, A., & Linnoila, M. (1989). CSF studies on alcoholism and related behaviors. Progress In Neuro-Psychopharmacology & Biological Psychiatry 13, 505–511.

    Google Scholar 

  • Roy, A., Virkkunen, M., & Linnoila, M. (1990). Serotonin in suicide, violence, and alcoholism. In E.F. Coccaro & D.L. Murphy (eds.), Serotonin in Major Psychiatric Disorders. Washington, DC: American Pyschiatric Press, pp. 187–208.

    Google Scholar 

  • Sellers, E., Toneatto, T., Romach, M., Somer, G., Sobell, L., & Sobell, M. (1994). Clinical efficacy of the 5-HT3 antagonist ondansetron in alcohol abuse and dependence. Alcoholism: Clinical and Experimental Research 18, 879–885.

    Google Scholar 

  • Svensson, L., Fahlke, C., Hard, E., & Engel, J.A. (1993). Involvement of the serotonergic system in ethanol intake in the rat. Alcohol 10, 219–224.

    Article  PubMed  Google Scholar 

  • Swift, R., Davidson, D., Whelihan, W., & Kuznetsov, O. (1996). Ondansetron alters human alcohol intoxication. Biological Psychiatry 40, 514–521.

    Article  PubMed  Google Scholar 

  • Tiihonen, J., Ryynanen, O.P., Kauhanen, J., Hakola, H.P.A., & Salaspuro, M. (1996). Citalopram in the treatment of alcoholism: A double-blind placebo-controlled study. Pharmacopsychiatry 29, 27–29.

    Article  PubMed  Google Scholar 

  • Tollefson, G.D., Montague-Clouse, J., & Tollefson, S.L. (1992). Treatment of comorbid generalized anxiety in a recently detoxified alcoholic population with a selective serotonergic drug (buspirone). Journal of Clinical Psychopharmacology 12, 19–26.

    PubMed  Google Scholar 

  • Virkkunen, M., Nuutila, A., Goodwin, F.K., & Linnoila, M. (1987). Cerebrospinal fluid monoamine metabolite levels in male arsonists. Archives of General Psychiatry 44, 241–247.

    PubMed  Google Scholar 

  • Wise, R. (1988). The neurobiology of craving: Implications for the understanding and treatment of addiction. Journal of Abnormal Psychology 97, 118–132.

    Article  PubMed  Google Scholar 

  • Yoshimoto, K., McBride, W.J., Lument, L., & Li, T.K. (1992). Ethanol enhances the release of dopamine and serotonin in the nucleus accumbens of HAD and LAD lines of rats Alcoholism: Clinical and Experimental Research 16, 781–785.

    Google Scholar 

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Authors and Affiliations

  1. Center for the Study of Addictions, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, 19104

    Helen M. Pettinati & Julie Madaras

  2. Alcohol Research Center, Department of Psychiatry, University of Connecticut School of Medicin, Farmington, Connecticut, 06030

    Henry R. Kranzler

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  1. New York University School of Medicine, New York, New York

    Marc Galanter

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Pettinati, H.M., Kranzler, H.R., Madaras, J. (2002). The Status of Serotonin-Selective Pharmacotherapy in the Treatment of Alcohol Dependence. In: Galanter, M., et al. Recent Developments in Alcoholism. Recent Developments in Alcoholism, vol 16. Springer, Boston, MA. https://doi.org/10.1007/0-306-47939-7_18

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  • DOI: https://doi.org/10.1007/0-306-47939-7_18

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