Chapter

Telocytes

Volume 913 of the series Advances in Experimental Medicine and Biology pp 177-191

Date:

Telocyte Behaviour During Inflammation, Repair and Tumour Stroma Formation

  • L. Díaz-FloresAffiliated withDepartment of Anatomy, Pathology, Histology and Radiology, Faculty of Medicine, University of La Laguna Email author 
  • , R. GutiérrezAffiliated withDepartment of Anatomy, Pathology, Histology and Radiology, Faculty of Medicine, University of La Laguna
  • , M. González-GómezAffiliated withDepartment of Anatomy, Pathology, Histology and Radiology, Faculty of Medicine, University of La Laguna
  • , L. Díaz-FloresJrAffiliated withDepartment of Anatomy, Pathology, Histology and Radiology, Faculty of Medicine, University of La Laguna
  • , F. ValladaresAffiliated withDepartment of Anatomy, Pathology, Histology and Radiology, Faculty of Medicine, University of La Laguna
  • , N. RancelAffiliated withDepartment of Anatomy, Pathology, Histology and Radiology, Faculty of Medicine, University of La Laguna
  • , F. J. SáezAffiliated withDepartment of Cell Biology and Histology, UFI11/44, School of Medicine and Dentistry, University of the Basque Country, UPV/EHU
  • , J. F. MadridAffiliated withDepartment of Cell Biology and Histology, School of Medicine, Regional Campus of International Excellence, “Campus Mare Nostrum” University of Murcia

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Abstract

In this chapter, we outline the role of human CD34+ stromal cells/telocytes (CD34+ SC/TCs) as progenitor cells during repair. The in vivo activation phenomena of CD34+ SC/TCs in this process include increased size; separation from the neighbouring structures (mainly of the vascular walls); association with inflammatory cells, predominantly macrophages; development of the organelles of synthesis (rough endoplasmic reticulum and Golgi apparatus); cell proliferation with presence of mitosis and high proliferative index (transit-amplifying cells); and fibroblastic and myofibroblastic differentiation. A procedure to study these tissue-resident cells, comparison of their behaviour in vivo and in vitro and different behaviour depending on location, time, type of injury (including tumour stroma) and greater or lesser proximity to the injury are also considered.