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Gastrointestinal Tumors in Children

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The Surgery of Childhood Tumors

Abstract

The presentation of a gastrointestinal tumor remains a rarity in the practice of surgery for children. Primary tumors of the gastrointestinal tract are estimated to compose less than 5 % of all pediatric neoplasms. Estimates as to the prevalence of primary gastrointestinal malignancies with the incorporation of gastrointestinal-associated lymphomas approach 1 % of all pediatric malignancies. Lymphomas compose roughly three-quarters of gastrointestinal-related malignancies. The clinical presentation of these tumors, which arise anywhere from the level of the esophagus to the rectum, is either incidental or based on symptoms related to the mass or mass-effect of the tumor. The majority of presenting symptoms includes abdominal pain and vomiting. The tumors of the gastrointestinal tract can best be categorized based on their cellular differentiation. By order of prevalence gastrointestinal-related malignancies are composed of lymphomas, sarcomas, carcinomas, neuroendocrine tumors, teratomas, and hyperplastic stromal tumors or polyps.

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References

  1. Longino LA, Martin LW. Abdominal mass in the newborn infant. Pediatrics. 1958;21:596–604.

    CAS  PubMed  Google Scholar 

  2. Pickett LK, Briggs HC. Cancer of the gastrointestinal tract in childhood. Pediatr Clin North Am. 1967;14:223–34.

    CAS  PubMed  Google Scholar 

  3. Zhuge Y, Cheung MC, Yang R, et al. Pediatric intestinal foregut and small bowel solid tumors: a review of 105 cases. J Surg Res. 2009;156:95–102.

    Article  PubMed  Google Scholar 

  4. Bethel CAI, Bhattacharyya N, Hutchinson C, et al. Alimentary tract malignancies in children. J Pediatr Surg. 1997;32:1004–9.

    Article  CAS  PubMed  Google Scholar 

  5. Hameed R, Parkes S, Davies P, Morland BJ. Paediatric malignant tumours of the gastrointestinal tract I the west midlands, UK, 1957–2000: a large population based survey. Pediatr Blood Cancer. 2004;43:257–60.

    Article  CAS  PubMed  Google Scholar 

  6. Ladd AP, Grosfeld JL. Gastrointestinal tumors in children and adolescents. Semin Pediatr Surg. 2006;15:37–47.

    Article  PubMed  Google Scholar 

  7. Wu TC, Chen LK, Lai CR. Primary gastric lymphoma associated with Helicobacter pylori in a child. J Pediatr Gastroenterol Nutr. 2001;32:608–10.

    Article  CAS  PubMed  Google Scholar 

  8. Horstmann M, Ertmann R, Winkler K. Relapse of MALT lymphoma associated with Helicobacter pylori after antibiotic treatment. Lancet. 1994;343:1098–9.

    Article  CAS  PubMed  Google Scholar 

  9. Pappo AS, Janeway K, LaQuaglia M, Kim SY. Special considerations in gastrointestinal tumors. J Surg Oncol. 2011;104:928–32.

    Article  PubMed  Google Scholar 

  10. Benesch M, Wardelmann E, Ferrari A, et al. Gastrointestinal stromal tumors (GIST) in children and adolescents: a comprehensive review of the current literature. Pediatr Blood Cancer. 2009;53:1171–9.

    Article  PubMed  Google Scholar 

  11. Janeway KA, Liegl B, Harlow A, et al. Pediatric KIT wild-type and platelet-derived growth factor receptor alpha-wild-type gastrointestinal stromal tumors share KIT activation but not mechanisms of genetic progression with adult gastrointestinal stromal tumors. Cancer Res. 2007;67:9084–8.

    Article  CAS  PubMed  Google Scholar 

  12. Kindblom LG, Remotti HE, Aldenborg F, et al. Gastrointestinal pacemaker cell tumor (GIPACT): gastrointestinal stromal tumors show phenotypic characteristics of the interstitial cells of Cajal. Am J Pathol. 1998;152:1259–69.

    CAS  PubMed  PubMed Central  Google Scholar 

  13. Sarlomo-Rikala M, Kovatich AJ, Barusevicius A, et al. CD117: a sensitive marker for gastrointestinal stromal tumors that is more specific than CD24. Mod Pathol. 1998;11:728–34.

    CAS  PubMed  Google Scholar 

  14. Cypriano MS, Jenkins JJ, Pappo AS, et al. Pediatric gastrointestinal stromal tumors and leiomyosarcoma: the St. Jude Children’s research hospital experience and a review of the literature. Cancer. 2004;101:39–50.

    Article  PubMed  Google Scholar 

  15. Young J, Miller RW. Incidence of malignant tumors in US children. J Pediatr. 1975;86:254–85.

    Article  PubMed  Google Scholar 

  16. Yannopoulos K, Stout AP. Smooth muscle tumors I children. Cancer. 1962;15:958–71.

    Article  CAS  PubMed  Google Scholar 

  17. Agaimy A, Wunsch PH. True smooth muscle neoplasms of the gastrointestinal tract: morphological spectrum and classification in a series of 85 cases from a single institute. Langen Arch Surg. 2007;392:75–81.

    Article  Google Scholar 

  18. O’Shea PA. Myogenic tumors of soft tissue. In: Coffin CM, Dehner LP, O’Shea PA, editors. Pediatric soft tissue tumors: a clinical, pathological, and therapeutic approach. Philadelphia: Lippincott Williams and Wilkins; 2002. p. 214–53.

    Google Scholar 

  19. De Saint Aubain Somerhausen N, Fletcher CD. Leiomyosarcoma of soft tissue in children; clinicopathologic analysis of 20 cases. Am J Surg Pathol. 1999;23:755–63.

    Article  CAS  PubMed  Google Scholar 

  20. Ranchod M, Kempson R. Smooth muscle tumors of the gastrointestinal tract and retroperitoneum. Cancer. 1977;39:255–62.

    Article  CAS  PubMed  Google Scholar 

  21. Kennedy Jr AP, Cameron B, Dorion RP, et al. Pediatric intestinal leiomyosarcoma: case report and review of the literature. J Pediatr Surg. 1997;32:1234–6.

    Article  PubMed  Google Scholar 

  22. Ferrari A, Bisogno G, Casanova M, et al. Childhood leiomyosarcoma: a report from the soft tissue sarcoma Italian Cooperative Group. Ann Oncol. 2001;12:1163–8.

    Article  CAS  PubMed  Google Scholar 

  23. Lack EE. Leiomyosarcomas in childhood: a clinical and pathologic study of 10 cases. Pediatr Pathol. 1986;6:181–97.

    Article  CAS  PubMed  Google Scholar 

  24. Hwarg ES, Gerald W, Wollner N, et al. Leiomyosarcoma in childhood and adolescence. Ann Surg Oncol. 1997;4:223–7.

    Article  Google Scholar 

  25. Yang R, Cheung MC, Zhuge Y, Armstrong C, Koniaris LG, Sola JE. Primary solid tumors of the colon and rectum in the pediatric patient: a review of 270 cases. J Surg Res. 2010;161:209–16.

    Article  PubMed  Google Scholar 

  26. Kravarusic D, Feigin E, Dlugy E, Steinberg R, Baazov A, Erez I, et al. Colorectal carcinoma in childhood: a retrospective multicenter study. J Pediatr Gastro Nutri. 2007;44:209–11.

    Article  Google Scholar 

  27. Israel National Cancer Registry. Available at: http://www.health.gov.il/icr. Accessed Nov 2005—reference 10.

  28. Hill DA, Furman WL, Billups CA, Riedley SE, Cain AM, Rao BN, et al. Colorectal carcinoma in childhood and adolescence: a clinicopathologic review. J Clin Oncol. 2007;25:5808–14.

    Article  PubMed  Google Scholar 

  29. Ibrahim K, Ciftci AO, Senocak ME, Buyukpamukcu N. Colorectal carcinoma in children. J Pediatr Surg. 1999;34:1499–504.

    Article  Google Scholar 

  30. Blumer SL, Anupindi SA, Adamson PC, Lin H, Price AP, Markowitz RI, et al. Sporadic adenocarcinoma on the colon in children: case series and review of the literature. J Pediatr Hematol Oncol. 2012;34:e137–41.

    Article  PubMed  Google Scholar 

  31. Durno C, Aronson M, Bapat B, et al. Family history and molecular features of children, adolescents, and young adults with colorectal carcinoma. Gut. 2005;54:1146–50.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  32. Salas-Valverde S, Lizano A, Gamboa Y, Vega S, Barrantes M, Santamariea S, Barrantes ZJ. Colon carcinoma in children and adolescents: prognostic factors and outcome—a review of 11 cases. Pediatr Surg Int. 2009;25:1073–6.

    Article  PubMed  Google Scholar 

  33. Vogelstein B. Genetic testings for cancer: the surgeon’s critical role: familial colon cancer. J Am Coll Surg. 1999;188:74–9.

    Article  CAS  PubMed  Google Scholar 

  34. Pratt CB, Rivera G, Shanks E, et al. Colorectal carcinoma in adolescents: implications regarding etiology. Cancer. 1977;40:2464–72.

    Article  CAS  PubMed  Google Scholar 

  35. Narla LD, Hingsbergen EA, Jones JE. Adult diseases in children. Pediatr Radiol. 1999;29:244–54.

    Article  CAS  PubMed  Google Scholar 

  36. Horie H, Iwasaki I, Takahashi H. Carcinoid in a gastrointestinal duplication. J Pediatr Surg. 1986;21:902–4.

    Article  CAS  PubMed  Google Scholar 

  37. Gosset A, Masson P. Tumeurs endocrines de l’appendice. Presse Med. 1914;25:237–40.

    Google Scholar 

  38. Spunt SL, Pratt CB, Rao BN, et al. Childhood carcinoid tumors: the St Jude children’s research hospital experience. J Pediatr Surg. 2000;35:1282–6.

    Article  CAS  PubMed  Google Scholar 

  39. Ellis L, Shale MJ, Coleman MP. Carcinoid tumors of the gastrointestinal tract: trends in incidence in England since 1971. Am J Gastroenterol. 2010;105:2563–9.

    Article  PubMed  Google Scholar 

  40. Schott M, Kloppel G, Raffel A, et al. Neuroendocrine neoplasms of the gastrointestinal tract. Dtsch Arztebl Int. 2011;108:305–12.

    PubMed  PubMed Central  Google Scholar 

  41. Modlin IM, Lye KD, Kidd M. A 5-decade analysis of 13,715 carcinoid tumors. Cancer. 2003;97:934–59.

    Article  PubMed  Google Scholar 

  42. Novartis Oncology. http://www.neuroendocrinetumor.com/pdf/NETs_Pathology_Report.pdf.

  43. Rindi G, Arnold R, Bosman FT, et al. Nomenclature and classification of neuroendocrine neoplasms of the digestive system. In: Bosman FT, Carneiro F, Jruban RH, Theise ND, editors. WHO classification of tumors of the digestives system. Lyon: IARC; 2010.

    Google Scholar 

  44. Moertel CL, Weiland LH, Telander RL. Carcinoid tumor of the appendix in the first two decades of life. J Pediatr Surg. 1990;25:1073–5.

    Article  CAS  PubMed  Google Scholar 

  45. Chow CW, Sane S, Campbell PE, Carter RF. Malignant carcinoid tumors in children. Cancer. 1982;49:802–11.

    Article  CAS  PubMed  Google Scholar 

  46. Suster F, Weinberg AG, Graivier L. Carcinoid tumor of the colon in a child. J Pediatr Surg. 1977;12:739–42.

    Article  CAS  PubMed  Google Scholar 

  47. Gold MS, Winslow PR, Litt IF. Carcinoid tumors of the rectum in children: a review of the literature and report of a case. Surgery. 1971;69:394–6.

    CAS  PubMed  Google Scholar 

  48. Buyukpamukcu M, Berberoglu S, Buyukpamukcu N, et al. Nonlymphoid gastrointestinal malignancies in Turkish children. Medical Pediatr Oncol. 1996;26:28–35.

    Article  CAS  Google Scholar 

  49. Nikou GC, Lygidakis NJ, Toubanakis C, et al. Current diagnosis and treatment of gastrointestinal carcinoids in a series of 101 patients: the significance of serum chromogranin-A, somatostatin receptor scintigraphy and somatostatin analogues. Hepato-Gastroenterol. 2005;52:731–41.

    Google Scholar 

  50. Dromain C, de Baere T, Lumbroso J, et al. Detection of liver metastases from endocrine tumors: a prospective comparison of somatostatin receptor scintigraphy, computed tomography, and magnetic resonance imaging. J Clin Oncol. 2005;23:70–8.

    Article  PubMed  Google Scholar 

  51. Chambers AJ, Pasieka JL, Dixon E, Rorstad O. The palliative benefit of aggressive surgical intervention for both hepatic and mesenteric metastases from neuroendocrine tumors. Surgery. 2008;144:645–53.

    Article  PubMed  Google Scholar 

  52. Rinke A, Muller HH, Schade-Brittinger C, et al. Placebo-controlled, double-blind, prospective, randomized study on the effect of octreotide LAR in the control of tumor growth in patients with metastatic neuroendocrine midgut tumors: a report from the PROMID study group. J Clin Oncol. 2009;27:4656–63.

    Article  CAS  PubMed  Google Scholar 

  53. Gupta DK, Srinivas M, Dave S, Agarwala S, Bajpai M, Mitra DK. Gastric teratoma in children. Pediatr Surg Int. 2000;16:329–32.

    Article  CAS  PubMed  Google Scholar 

  54. Isaacs Jr H. Perinatal (feal and neonatal) germ cell tumors. J Pediatr Surg. 2004;39:1003–13.

    Article  PubMed  Google Scholar 

  55. Grosfeld JL, Ballantine TVN, Lowe D, Baehner RL. Benign and malignant teratomas in children: analysis of 85 patients. Surgery. 1976;3:297–305.

    Google Scholar 

  56. Shah RS, Kaddu SJ, Kirtane JM. Benign mature teratoma of the large bowel: a case report. J Pediatr Surg. 1996;31:701–2.

    Article  CAS  PubMed  Google Scholar 

  57. Salame G, Sherer DM, Shah T, Serur E, Dalal S, Dalloul M, Abulafia O. Mature cystic teratoma of the sigmoid colon. Ultrasound Obstet Gynecol. 2011;37:739–42.

    Article  CAS  PubMed  Google Scholar 

  58. Sharma D, Kumar S, Tandon A, Ghosh Kar A, Kumar M, Shukla VK. Primary rectal teratoma. Surgery. 2008;143:570–1.

    Article  PubMed  Google Scholar 

  59. Bourke CJ, Mackay AJ, Payton D. malignant gastric teratoma: case report. Pediatr Surg Int. 1997;12:192–3.

    Article  CAS  Google Scholar 

  60. Mahour GH, Wooley MM, Trivedi SN, et al. Teratomas in infancy and childhood: experience with 81 cases. Surgery. 1974;76:309–18.

    CAS  PubMed  Google Scholar 

  61. Curtis JL, Burns RC, Wang L, Mahour GH, Ford HR. Primary gastric tumors of infancy and childhood: 54-year experience at a single institution. J Pediatr Surg. 2008;43:1487–93.

    Article  PubMed  Google Scholar 

  62. Cairo MS, Grosfeld JL, Wheetman RM. Gastric teratoma—unusual case for bleeding of the upper gastrointestinal tract in the newborn. Pediatrics. 1981;67:721–4.

    CAS  PubMed  Google Scholar 

  63. Gangopadhyay AN, Pandit SK, Gopal DS. Gastric teratoma revealed by gastrointestinal hemorrhage. Ind Pediagtr. 1992;29:1145–7.

    Google Scholar 

  64. Haley T, Dimmler M, Hollier P. Gastric teratoma with gastrointestinal bleeding. J Pediatr Surg. 1986;21:949–50.

    Article  CAS  PubMed  Google Scholar 

  65. Bakunai S, Ochida H. A case report of large gastric teratoma with perforation. Tokyo Med. 1960;77:373–4.

    Google Scholar 

  66. Gitlin D. Sites of alpha fetoprotein synthesis. N Engl J Med. 1971;285:1436–8.

    CAS  PubMed  Google Scholar 

  67. Tsuchida U, Urano Y, Endo Y. A study on alpha fetoprotein and endodermal sinus tumor. J Pediatr Surg. 1975;10:501–5.

    Article  CAS  PubMed  Google Scholar 

  68. Marina NM, Cushing B, Giller R, et al. Complete surgical excision is effective treatment for children with immature teratomas with or without malignant elements: a pediatric oncology group/children’s cancer group intergroup study. J Clin Oncol. 1999;17:2137–43.

    CAS  PubMed  Google Scholar 

  69. Utsch B, Fleischhack F, Knopfle G, Hasan C, Bode U. Immature gastric teratoma of the lesser curvature in a male infant. J Pediatr Gastroent and Nutri. 2001;32:204–6.

    Article  CAS  Google Scholar 

  70. Gobel U, Calaminus G, Blohn M, et al. Extracranial non-testicular teratoma in childhood and adolescence: introduction of a risk score for stratification of therapy. Klin Padiatr. 1997;209:228–34.

    Article  CAS  PubMed  Google Scholar 

  71. Corpcioglu F, Ekingen G, Sarper N, Guvenc BH. Immature gastric teratoma of childhood: a case report and review of the literature. J Pediatr Gastroent Nutri. 2004;39:292–4.

    Article  Google Scholar 

  72. Sanders BM, West KW, Gingalewski C, Engum S, Davis M, Grosfeld JL. Inflammatory pseudotumor of the alimentary tract: clinical and surgical experience. J Pediatr Surg. 2001;36:169–73.

    Article  CAS  PubMed  Google Scholar 

  73. Karnak I, Senocak ME, Ciftci AO, Caglar M, Bingol-Gologlu M, Tanyel C, et al. Inflammatory myofibroblastic tumor in children: diagnosis and treatment. J Pediatr Surg. 2001;36:908–12.

    Article  CAS  PubMed  Google Scholar 

  74. Coffin CM, Dehner LP, Meis-Kindblom JM. Inflammatory myoblastic tumor, inflammatory fibrosarcoma, and related lesions: An historical review with differential diagnostic considerations. Semin Diagn Pathol. 1998;15:102–10.

    CAS  PubMed  Google Scholar 

  75. Demirkan NC, Akalin T, Yilmaz F, Ozgenc F, Ozcan C, et al. Inflammatory myfibroblastic tumor of small bowel wall in childhood: report of a case and a review of the literature. Path Int. 2001;51:47–9.

    Article  CAS  Google Scholar 

  76. DiFiore JW, Goldblum JR. Inflammatory myofibroblastic tumor of the small intestine. Am Col Surg. 2002;194:502–6.

    Article  Google Scholar 

  77. Coffin CM, Watterson J, Priest JR, et al. Extrapulmonary inflammatory myfibroblastic tumor (inflammatory pseudotumor) of soft tissue into sarcoma after several recurrences. Hum Pathol. 1996;27:1095.

    Article  Google Scholar 

  78. Estevao-Costa J, Corriea-Pinto J, Rodrigues FC, Carvalho JL, Campos M, et al. Gastric inflammatory myofibroblastic proliferation in children. Pediatr Surg Int. 1998;13:95–9.

    Article  CAS  PubMed  Google Scholar 

  79. Ntloko S, Gounden A, Naidoo M, Madiba TE, Sing Y, Ramdial PK, et al. Intestinal inflammatory myofibroblastic tumour. SAJS. 2011;49:190–3.

    CAS  Google Scholar 

  80. Apa J, Diniz F, Saritas T, et al. Abdominal inflammatory myofibroblastic tumour: review of literature by means of case report. Turk J Cancer. 2002;32:28–31.

    Google Scholar 

  81. Souid AK, Ziemba MC, Dubansky AS, et al. Inflammatory myfibroblastic tumour in children. Cancer. 1993;72:2042–3.

    Article  CAS  PubMed  Google Scholar 

  82. Milne ANA, Sweeney KJ, O’Riodain DS, et al. Inflammatory myofibroblastic tumour with ALK/TPM3 fusion presenting as ileocolic intussusception: an usual presentation of an unusual neoplasm. Hum Pathol. 2006;37:112–6.

    Article  PubMed  Google Scholar 

  83. Coffin CM, Hornick JL, Fletcher CD. Inflammatory myfibroblastic tumour: comparison of clinicopathologic, histologic, and immunohistochemical features including ALK expression in atypical and aggressive cases. Am J Surg Pathol. 2007;31:509–20.

    Article  PubMed  Google Scholar 

  84. Tsuzuki T, Magi-Galuzzi C, Epstein JL. ALK-1 expression in inflammatory myofibroblastic tumour of the urinary bladder. Am J Surg Pathol. 2004;28:1609–14.

    Article  PubMed  Google Scholar 

  85. Zhou X, Luo C, Lv S, Gan M. Inflammatory myofibroblastic tumor of the rectum in a 13-month-old girl: a case report. J Pediatr Surg. 2011;46:E1–4.

    Article  PubMed  Google Scholar 

  86. Hussong JW, Brown M, Perkins SL, et al. Comparison of DNA ploidy, histologic and immunohistochemical findings with clinical outcome in inflammatory myfibroblastic tumors. Mod Pathol. 1999;12:279–86.

    CAS  PubMed  Google Scholar 

  87. Meis-Kindblom JM, Kjellstrom C, Kindblom LG, et al. Inflammatory fibrosarcoma: update, reappraisal and perspective on its place in the spectrum of inflammatory myofibroblastic tumours. Sem Diag Pathol. 1998;15:133–43.

    CAS  Google Scholar 

  88. Khoddami M, Sanai S, Nikkhoo B, et al. rectal and appendiceal inflammatory myofibroblastic tumours. Arch Iran Med. 2006;9:277–81.

    PubMed  Google Scholar 

  89. Sahnoun L, Elezzi O, Maazoun K, et al. Ovarian inflammatory myofibroblastic tumor in children. J Pediatr Adolesc Gynecol. 2007;20:365–6.

    Article  PubMed  Google Scholar 

  90. Ciftci AO, Akcoren Z, Tanyel FC, et al. Inflammatory pseudotumor causing intestinal obstruction; diagnostic and therapeutic aspects. J Pediatr Surg. 1988;33:1843–5.

    Article  Google Scholar 

  91. Day DL, Sane S, Dehner LP. Inflammatory pseudotumor of the mesentery and small intestine. Pediatr Radiol. 1986;16:210–5.

    Article  CAS  PubMed  Google Scholar 

  92. Lazure T, Ferlicot S, Gauthier F, Doz F, Couturier J, Fabre DM, Bedossa P. Gastric inflammatory myofibroblastic tumors in children: an unpredictable course. J Pediatr Gastro Nutri. 2002;34:319–22.

    Article  Google Scholar 

  93. Meis JM, Enzinger FM. Inflammatory fibrosarcoma of the mesentery and retroperitoneum. A tumor closely simulating inflammatory pseudotumor. Am J Surg Pathol. 1991;15:1146–56.

    Article  CAS  PubMed  Google Scholar 

  94. Kerr JZ, Hicks MJ, Nuchtern JG, et al. Gastrointestinal autonomic nerve tumors I the pediatric population. A report of four cases and a review of the literature. Cancer. 1999;85:220–30.

    Article  CAS  PubMed  Google Scholar 

  95. Coffin CM, Pappin AL. Polyps and neoplasms of the gastrointestinal tract in childhood and adolescence. In: Dahms BB, Qualman SJ, editors. Gastrointestinal diseases, Perspectives in pediatric pathology, vol. 20. Basel: Karger; 1997. p. 127–71.

    Chapter  Google Scholar 

  96. Applebaum J, Kieran MW, Cripe TP, Coffin CM, Collins MH, Kaipainen A, et al. The rationale for nonsteroidal anti-inflammatory drug therapy for inflammatory myofibroblastic tumors: a Children’s Oncology Group study. J Pediatr Surg. 2005;40:999–1003.

    Article  PubMed  Google Scholar 

  97. Germanidis F, Xanthakis I, Tsitouridis I, et al. Regression of inflammatory myfibroblastic tumour of the gastrointestinal tract under infliximab treatment. Dig Dis Sci. 2005;50:262–5.

    Article  PubMed  Google Scholar 

  98. Ciftci AO, Akcoren Z, Tanyel FC, et al. Inflammatory pseudotumour causing intestinal obstruction: diagnostic and therapeutic aspects. J Pediatr Surg. 1998;3:1843–5.

    Article  Google Scholar 

  99. Dao AH, Hodges KB. Inflammatory pseudotumor of the pelvis: case report with review of recent developments. Am Surg. 1998;64:1188–91.

    CAS  PubMed  Google Scholar 

  100. Bajaj P, Harris L, Vermillion JM, et al. An uncommon presentation of inflammatory myfibroblastic tumour. Hosp Physician. 2007;43:27–30.

    Google Scholar 

  101. Coffin CM, Waterson J, Prients JR, et al. Extrapulmonary inflammatory myofibroblastic tumor (inflammatory pseudo-tumor): A clinical and immunohistochemical study of 84 cases. Am J Surg Pathol. 1995;19:859–72.

    Article  CAS  PubMed  Google Scholar 

  102. Coffin CM, Humphrey PA, Dehner LP. Extrapulmonary inflammatory myfibroblastic tumor: a clinical and pathologic survey. Semin Diagn Pathol. 1998;15:85–101.

    CAS  PubMed  Google Scholar 

  103. Attard TM, Young RJ. Diagnosis and management of gastrointestinal polyps. Gastroenterol Nurs. 2005;29:16–22.

    Article  Google Scholar 

  104. Barnard J. Screening and surveillance recommendations for pediatric gastrointestinal polyposis syndromes. J Pediatr Gastroenterol Nutr. 2009;48 suppl 2:S75–8.

    Article  PubMed  PubMed Central  Google Scholar 

  105. Kinzler KW, Nilbert MC, Vogelstein B, et al. Identification of a gene located at chromosome 5q21 that is mutated in colorectal cancers. Science. 1991;251:1366–70.

    Article  CAS  PubMed  Google Scholar 

  106. Sampson JR, Dolwant I, Jones S, et al. Autosomal recessive colorectal adenomatous polyposis due to inherited mutations of MYH. Lancet. 2003;362:39–41.

    Article  CAS  PubMed  Google Scholar 

  107. Desai DC, Neale KF, Talbot IC, et al. Juvenile polyposis. Br J Surg. 1995;82:14–7.

    Article  CAS  PubMed  Google Scholar 

  108. Coburn MC, Pricolo VE, DeLuca FG, et al. Malignant potential in intestinal juvenile polyposis syndromes. Ann Surg Onc. 1995;2:386–91.

    Article  CAS  Google Scholar 

  109. Tovar JA, Eizaguirre I, Albert A, et al. Peutz-Jeghers syndrome. Its natural course and management. Johns Hopkins Med J. 1975;136:71–82.

    Google Scholar 

  110. McGarrity RJ, Kulin HE, Zaino RJ. Peutz-Jeghers syndrome. Am J Gastroenterol. 2000;95:596–604.

    Article  CAS  PubMed  Google Scholar 

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Ladd, A.P., Grosfeld, J.L. (2016). Gastrointestinal Tumors in Children. In: Carachi, R., Grosfeld, J. (eds) The Surgery of Childhood Tumors. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-48590-3_15

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