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Fusarins and Fusaric Acid in Fusaria

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Biosynthesis and Molecular Genetics of Fungal Secondary Metabolites

Part of the book series: Fungal Biology ((FUNGBIO))

Abstract

Fusaric acid (FA) and fusarins are two polyketides produced by a broad range of Fusarium species. Different methods have been developed for detection and structural analysis of both compounds. Some of the fusarins are mutagenic while FA is a plant toxin that contributes to the severity of different crop diseases. Examples of FA toxicity against plants, amoebas, bacteria, and viruses are given. Animals and humans are also affected by consumption of FA-contaminated feed and food, respectively. Their symptoms are hypotension, lack of appetite, vomit, and loss of weight. This chapter describes some of the many different pharmacological effects on humans. Fusarin and FA gene clusters have recently been identified and characterized in Fusarium fujikuroi and have been compared to the ones in other species. Both mycotoxins are produced under nitrogen excess and are regulated by pH. Regulation of the clusters has been studied at gene expression level, and the effect of global regulators such as velvet complex, LaeA or histone acetylation.

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Authors and Affiliations

  1. University of Münster, Institute of Biology und Biotechnology of Plants, Schlossplatz 8, D-48143, Münster, Germany

    Eva-Maria Niehaus & Bettina Tudzynski

  2. Departamento de Genética, Universidad de Sevilla, E-41012, Sevilla, Spain

    Violeta Díaz-Sánchez & M. Carmen Limón

  3. University of Münster, Institute of Food Chemistry, Corrensstr. 45, Münster, D-48149, Germany

    Katharina Walburga von Bargen, Karin Kleigrewe & Hans-Ulrich Humpf

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  1. Eva-Maria Niehaus
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  2. Violeta Díaz-Sánchez
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  3. Katharina Walburga von Bargen
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  4. Karin Kleigrewe
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  5. Hans-Ulrich Humpf
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  6. M. Carmen Limón
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  7. Bettina Tudzynski
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Correspondence to M. Carmen Limón or Bettina Tudzynski .

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  1. Department of Molecular Biology, University of León, León, Spain

    Juan-Francisco Martín

  2. Parque Científico de León, Instituto de Biotecnología de León (INBIOTEC), León, Spain

    Carlos García-Estrada

  3. Institute of Chemical Engineering, Vienna University of Technology, Vienna, Austria

    Susanne Zeilinger

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Niehaus, EM. et al. (2014). Fusarins and Fusaric Acid in Fusaria . In: Martín, JF., García-Estrada, C., Zeilinger, S. (eds) Biosynthesis and Molecular Genetics of Fungal Secondary Metabolites. Fungal Biology. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-1191-2_11

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