Skip to main content

Stereotactic Radiosurgery for Psychiatric and Pain Disorders

  • Chapter
Principles and Practice of Stereotactic Radiosurgery

Abstract

Since its inception, stereotactic radiosurgery has been utilized to treat functional disorders of the brain. These have included psychiatric conditions such as intractable obsessive-compulsive disorder. It has also been employed to treat medically refractory pain disorders of which trigeminal neuralgia is the most commonly treated pain condition. Radiosurgery offers a minimally invasive option for treating functional disorders while avoiding the need for costly neural stimulators or lifelong medical therapy. In treating patients with functional disorders, high radiosurgical doses are employed. As such, a thorough understanding of the target anatomy is required along with a high degree of accuracy and precision in the radiosurgical delivery. Advanced neuro-imaging will shed light on the underlying changes effectuated by radiosurgery and likely lead to refinements in the radiosurgical technique for indications of psychiatric and pain disorders.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 249.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Helfant MH, Leksell L, Strang RR. Experiences with intractable pain treated by stereotaxic mesencephalotomy. Acta Chir Scand. 1965;129:573–80.

    CAS  PubMed  Google Scholar 

  2. Leksell L. Brain fragments. In: Steiner L, Forster D, Backlund E-O, editors. Radiosurgery: baseline and trends. New York: Raven; 1992. p. 263–92.

    Google Scholar 

  3. Leksell L. Sterotaxic radiosurgery in trigeminal neuralgia. Acta Chir Scand. 1971;137:311–4.

    CAS  PubMed  Google Scholar 

  4. Leksell L. Trigeminal neuralgia. Some neurophysiologic aspects and a new method of therapy. Lakartidningen. 1971;68:5145–8.

    CAS  PubMed  Google Scholar 

  5. Hakanson S. Transoval trigeminal cisternography. Surg Neurol. 1978;10:137–44.

    CAS  PubMed  Google Scholar 

  6. Bingley T, Leksell L, Meyerson BA, et al. Long term results of stereotactic capsulotomy in chronic obsessive-compulsive neurosis. In: Sweet WH, Obrador AS, editors. Neurosurgical treatment in psychiatry, pain and epilepsy. Baltimore: University Park Press; 1977. p. 287–99.

    Google Scholar 

  7. Flickinger JC, Lunsford LD, Kondziolka D. Dose-volume considerations in radiosurgery. Stereotact Funct Neurosurg. 1991;57:99–105.

    Article  CAS  PubMed  Google Scholar 

  8. Kamiryo T, Kassell NF, Thai QA, Lopes MB, Lee KS, Steiner L. Histological changes in the normal rat brain after gamma irradiation. Acta Neurochir (Wien). 1996;138:451–9.

    Article  CAS  Google Scholar 

  9. Mindus P. Capsulotomy in anxiety disorders—a multidisciplinary study. Dissertation at the Karolinska Institute and Hospital, Stockholm, Sweden, 1991. p. 8

    Google Scholar 

  10. Mindus P. Capsulotomy in anxiety disorders—a multidisciplinary study. Dissertation at the Karolinska Institute and Hospital, Stockholm, Sweden, 1991. p. 13

    Google Scholar 

  11. Young RF, Jacques DS, Rand RW, Copcutt BC, Vermeulen SS, Posewitz AE. Technique of stereotactic medial thalamotomy with the Leksell Gamma Knife for treatment of chronic pain. Neurol Res. 1995;17:59–65.

    CAS  PubMed  Google Scholar 

  12. Young RF, Jacques DS, Rand RW, Copcutt BR. Medial thalamotomy with the Leksell Gamma Knife for treatment of chronic pain. Acta Neurochir Suppl. 1994;62:105–10.

    Article  CAS  PubMed  Google Scholar 

  13. Young RF, Vermeulen SS, Grimm P, Posewitz AE, Jacques DB, Rand RW, et al. Gamma Knife thalamotomy for the treatment of persistent pain. Stereotact Funct Neurosurg. 1995;64 Suppl 1:172–81.

    PubMed  Google Scholar 

  14. Romanelli P, Esposito V, Adler J. Ablative procedures for chronic pain. Neurosurg Clin N Am. 2004;15:335–42.

    Article  PubMed  Google Scholar 

  15. Olivecrona H. Die trigeminusneuralgie und ihre behandlung. Nervenarzt. 1941;14:49–57.

    Google Scholar 

  16. Granit R, Leksell L, Skoglund CR. Fibre interaction in injured or compressed region of nerve. Brain. 1944;67:125–40.

    Article  Google Scholar 

  17. Barker 2nd FG, Jannetta PJ, Bissonette DJ, Larkins MV, Jho HD. The long-term outcome of microvascular decompression for trigeminal neuralgia. N Engl J Med. 1996;334:1077–83.

    Article  PubMed  Google Scholar 

  18. Jannetta PJ. Arterial compression of the trigeminal nerve at the pons in patients with trigeminal neuralgia. J Neurosurg. 1967;26(Suppl):159–62.

    Article  PubMed  Google Scholar 

  19. Lovely TJ, Jannetta PJ. Microvascular decompression for trigeminal neuralgia. Surgical technique and long-term results. Neurosurg Clin N Am. 1997;8:11–29.

    CAS  PubMed  Google Scholar 

  20. Brown JA, Chittum CJ, Sabol D, Gouda JJ. Percutaneous balloon compression of the trigeminal nerve for treatment of trigeminal neuralgia. Neurosurg Focus. 1996;1(2):e4; discussion 1 p following e4.

    Article  CAS  PubMed  Google Scholar 

  21. Brown JA, Gouda JJ. Percutaneous balloon compression of the trigeminal nerve. Neurosurg Clin N Am. 1997;8:53–62.

    CAS  PubMed  Google Scholar 

  22. Kondziolka D, Lunsford LD, Flickinger JC, Young RF, Vermeulen S, Duma CM, et al. Stereotactic radiosurgery for trigeminal neuralgia: a multiinstitutional study using the gamma unit. J Neurosurg. 1996;84:940–5.

    Article  CAS  PubMed  Google Scholar 

  23. Massager N, Lorenzoni J, Devriendt D, Desmedt F, Brotchi J, Levivier M. Gamma knife surgery for idiopathic trigeminal neuralgia performed using a far-anterior cisternal target and a high dose of radiation. J Neurosurg. 2004;100:597–605.

    Article  PubMed  Google Scholar 

  24. Zhang P, Brisman R, Choi J, Li X. Where to locate the isocenter? The treatment strategy for repeat trigeminal neuralgia radiosurgery. Int J Radiat Oncol Biol Phys. 2005;62:38–43.

    Article  PubMed  Google Scholar 

  25. Pollock BE, Kondziolka D. Stereotactic radiosurgical treatment of sphenopalatine neuralgia. Case report. J Neurosurg. 1997;87:450–3.

    Article  CAS  PubMed  Google Scholar 

  26. Stieber VW, Bourland JD, Ellis TL. Glossopharyngeal neuralgia treated with gamma knife surgery: treatment outcome and failure analysis. Case report. J Neurosurg. 2005;102(Suppl):155–7.

    Article  PubMed  Google Scholar 

  27. Mindus P. Capsulotomy in anxiety disorders—a multidisciplinary study. Dissertation at the Karolinska Institute and Hospital, Stockholm, Sweden, 1991. p. 15

    Google Scholar 

  28. Leksell L, Herner T, Leksell D, Persson B, Lindquist C. Visualisation of stereotactic radiolesions by nuclear magnetic resonance. J Neurol Neurosurg Psychiatry. 1985;48:19–20.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  29. Lippitz BE, Mindus P, Meyerson BA, Kihlstrom L, Lindquist C. Lesion topography and outcome after thermocapsulotomy or gamma knife capsulotomy for obsessive-compulsive disorder: relevance of the right hemisphere. Neurosurgery. 1999;44:452–8; discussion 458–60.

    Article  CAS  PubMed  Google Scholar 

  30. Cosgrove GR, Rauch SL. Stereotactic cingulotomy. Neurosurg Clin N Am. 2003;14:225–35.

    Article  PubMed  Google Scholar 

  31. Kelly D, Mitchell-Heggs N. Stereotactic limbic leucotomy—a follow-up study of thirty patients. Postgrad Med J. 1973;49:865–82.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  32. Kelly D, Richardson A, Mitchell-Heggs N, Greenup J, Chen C, Hafner RJ. Stereotactic limbic leucotomy: a preliminary report on forty patients. Br J Psychiatry. 1973;123:141–8.

    Article  CAS  PubMed  Google Scholar 

  33. Richardson A. Stereotactic limbic leucotomy: surgical technique. Postgrad Med J. 1973;49:860–4.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  34. Kihlstrom L, Guo WY, Lindquist C, Mindus P. Radiobiology of radiosurgery for refractory anxiety disorders. Neurosurgery. 1995;36:294–302.

    Article  CAS  PubMed  Google Scholar 

  35. Kihlstrom L, Hindmarsh T, Lax I, Lippitz B, Mindus P, Lindquist C. Radiosurgical lesions in the normal human brain 17 years after gamma knife capsulotomy. Neurosurgery. 1997;41:396–401; discussion 401–2.

    Article  CAS  PubMed  Google Scholar 

  36. Khadilkar A, Milne S, Brosseau L, Robinson V, Saginur M, Shea B, et al. Transcutaneous electrical nerve stimulation (TENS) for chronic low-back pain. Cochrane Database Syst Rev. 2005:CD003008

    Google Scholar 

  37. Multon S, Schoenen J. Pain control by vagus nerve stimulation: from animal to man … and back. Acta Neurol Belg. 2005;105:62–7.

    PubMed  Google Scholar 

  38. Turk DC. Clinical effectiveness and cost-effectiveness of treatments for patients with chronic pain. Clin J Pain. 2002;18:355–65.

    Article  PubMed  Google Scholar 

  39. Hamid AI, Qureshi AA, Bhatti IH. Percutaneous radiofrequency retrogasserian rhizotomy for trigeminal neuralgia. J Pak Med Assoc. 1993;43:132–3.

    CAS  PubMed  Google Scholar 

  40. Henson CF, Goldman HW, Rosenwasser RH, Downes MB, Bednarz G, Pequignot EC, et al. Glycerol rhizotomy versus gamma knife radiosurgery for the treatment of trigeminal neuralgia: an analysis of patients treated at one institution. Int J Radiat Oncol Biol Phys. 2005;63:82–90.

    Article  PubMed  Google Scholar 

  41. Lunsford LD. Glycerol rhizotomy for trigeminal neuralgia. J Neurosurg. 1987;66:151–2.

    CAS  PubMed  Google Scholar 

  42. Greenberg BD, Price LH, Rauch SL, Friehs G, Noren G, Malone D, et al. Neurosurgery for intractable obsessive-compulsive disorder and depression: critical issues. Neurosurg Clin N Am. 2003;14:199–212.

    Article  PubMed  Google Scholar 

  43. Rasmussen SA, Eisen JL. The epidemiology and clinical features of obsessive compulsive disorder. Psychiatr Clin North Am. 1992;15:743–58.

    CAS  PubMed  Google Scholar 

  44. Fava M, Davidson KG. Definition and epidemiology of treatment-resistant depression. Psychiatr Clin North Am. 1996;19:179–200.

    Article  CAS  PubMed  Google Scholar 

  45. Pallanti S, Hollander E, Goodman WK. A qualitative analysis of nonresponse: management of treatment-refractory obsessive-compulsive disorder. J Clin Psychiatry. 2004;65 Suppl 14:6–10.

    CAS  PubMed  Google Scholar 

  46. Blomstedt P, Hariz MI. Hardware-related complications of deep brain stimulation: a ten year experience. Acta Neurochir (Wien). 2005;147:1061–4.

    Article  CAS  Google Scholar 

  47. Kondziolka D, Whiting D, Germanwala A, Oh M. Hardware-related complications after placement of thalamic deep brain stimulator systems. Stereotact Funct Neurosurg. 2002;79:228–33.

    Article  PubMed  Google Scholar 

  48. Smyth MD, Tubbs RS, Bebin EM, Grabb PA, Blount JP. Complications of chronic vagus nerve stimulation for epilepsy in children. J Neurosurg. 2003;99:500–3.

    Article  PubMed  Google Scholar 

  49. Jannetta PJ. Outcome after microvascular decompression for typical trigeminal neuralgia, hemifacial spasm, tinnitus, disabling positional vertigo, and glossopharyngeal neuralgia (honored guest lecture). Clin Neurosurg. 1997;44:331–83.

    CAS  PubMed  Google Scholar 

  50. Burchiel KJ, Clarke H, Haglund M, Loeser JD. Long-term efficacy of microvascular decompression in trigeminal neuralgia. J Neurosurg. 1988;69:35–8.

    Article  CAS  PubMed  Google Scholar 

  51. Friehs GM, Noren G, Ohye C, Duma CM, Marks R, Plombon J, et al. Lesion size following Gamma Knife treatment for functional disorders. Stereotact Funct Neurosurg. 1996;66 Suppl 1:320–8.

    Article  PubMed  Google Scholar 

  52. Frighetto L, De Salles A, Wallace R, Ford J, Selch M, Cabatan-Awang C, et al. Linear accelerator thalamotomy. Surg Neurol. 2004;62:106–13; discussion 113–4.

    Article  PubMed  Google Scholar 

  53. Brisman R. Gamma knife surgery with a dose of 75 to 76.8 Gray for trigeminal neuralgia. J Neurosurg. 2004;100:848–54.

    Article  PubMed  Google Scholar 

  54. Petit JH, Herman JM, Nagda S, DiBiase SJ, Chin LS. Radiosurgical treatment of trigeminal neuralgia: evaluating quality of life and treatment outcomes. Int J Radiat Oncol Biol Phys. 2003;56:1147–53.

    Article  PubMed  Google Scholar 

  55. Pollock BE, Phuong LK, Foote RL, Stafford SL, Gorman DA. High-dose trigeminal neuralgia radiosurgery associated with increased risk of trigeminal nerve dysfunction. Neurosurgery. 2001;49:58–62; discussion 62–4.

    CAS  PubMed  Google Scholar 

  56. Richards GM, Bradley KA, Tome WA, Bentzen SM, Resnick DK, Mehta MP. Linear accelerator radiosurgery for trigeminal neuralgia. Neurosurgery. 2005;57:1193–200; discussion 1193–200.

    Article  PubMed  Google Scholar 

  57. Sheehan J, Pan HC, Stroila M, Steiner L. Gamma knife surgery for trigeminal neuralgia: outcomes and prognostic factors. J Neurosurg. 2005;102:434–41.

    Article  PubMed  Google Scholar 

  58. Tawk RG, Duffy-Fronckowiak M, Scott BE, Alberico RA, Diaz AZ, Podgorsak MB, et al. Stereotactic gamma knife surgery for trigeminal neuralgia: detailed analysis of treatment response. J Neurosurg. 2005;102:442–9.

    Article  PubMed  Google Scholar 

  59. Williams BJ, Schlesinger D, Sheehan J. Glossopharyngeal neuralgia treated with gamma knife radiosurgery. World Neurosurg. 2010;73:413–7.

    Article  PubMed  Google Scholar 

  60. Pollock BE, Boes CJ. Stereotactic radiosurgery for glossopharyngeal neuralgia: preliminary report of 5 cases. J Neurosurg. 2011;115:936–9.

    Article  PubMed  Google Scholar 

  61. Ma L, Kwok Y, Chin LS, Yu C, Regine WF. Comparative analyses of linac and Gamma Knife radiosurgery for trigeminal neuralgia treatments. Phys Med Biol. 2005;50:5217–27.

    Article  CAS  PubMed  Google Scholar 

  62. Smith ZA, De Salles AA, Frighetto L, Goss B, Lee SP, Selch M, et al. Dedicated linear accelerator radiosurgery for the treatment of trigeminal neuralgia. J Neurosurg. 2003;99:511–6.

    Article  PubMed  Google Scholar 

  63. Steiner L, Forster D, Leksell L, Meyerson BA, Boethius J. Gammathalamotomy in intractable pain. Acta Neurochir (Wien). 1980;52:173–84.

    Article  CAS  Google Scholar 

  64. Hayashi M, Taira T, Chernov M, Izawa M, Liscak R, Yu CP, et al. Role of pituitary radiosurgery for the management of intractable pain and potential future applications. Stereotact Funct Neurosurg. 2003;81:75–83.

    Article  PubMed  Google Scholar 

  65. Mindus P. Capsulotomy in anxiety disorders—a multidisciplinary study. Dissertation at the Karolinska Institute and Hospital, Stockholm, Sweden, 1991. p. 43

    Google Scholar 

  66. Mindus P. Capsulotomy in anxiety disorders—a multidisciplinary study. Dissertation at the Karolinska Institute and Hospital, Stockholm, Sweden, 1991. p. 44

    Google Scholar 

  67. Kondziolka D, Flickinger JC, Hudak R. Results following gamma knife radiosurgical anterior capsulotomies for obsessive compulsive disorder. Neurosurgery. 2011;68:28–32.

    Google Scholar 

  68. Price BH, Baral I, Cosgrove GR, Rauch SL, Nierenberg AA, Jenike MA, et al. Improvement in severe self-mutilation following limbic leucotomy: a series of 5 consecutive cases. J Clin Psychiatry. 2001;62:925–32.

    Article  CAS  PubMed  Google Scholar 

  69. Ganz JC. Gamma knife radiosurgery and its possible relationship to malignancy: a review. J Neurosurg. 2002;97:644–52.

    PubMed  Google Scholar 

  70. Lim YJ, Leem W, Park JT, Kim TS, Rhee BA, Kim GK. Cerebral infarction with ICA occlusion after Gamma Knife radiosurgery for pituitary adenoma: a case report. Stereotact Funct Neurosurg. 1999;72 Suppl 1:132–9.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Jason P. Sheehan M.D., Ph.D. .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2015 Springer Science+Business Media New York

About this chapter

Cite this chapter

Yen, CP., Sheehan, J.P. (2015). Stereotactic Radiosurgery for Psychiatric and Pain Disorders. In: Chin, L., Regine, W. (eds) Principles and Practice of Stereotactic Radiosurgery. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-8363-2_61

Download citation

  • DOI: https://doi.org/10.1007/978-1-4614-8363-2_61

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4614-8362-5

  • Online ISBN: 978-1-4614-8363-2

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics