Abstract
2.2′ -anhydro-1-(B-D-arabinosyl)-5-fluorocytosine hydrochloride (fluorocyclocytidine, AAFC), is a pyrimidine analog with anti-tumor activity in experimental animal tumors. AAFC is hydrolysed to arabinosyl-fluorocytosine wich, as arabinosyl-cytosine, inhibits DNA-polymerase activity. AAFC is also deaminated to arabinosyl-fluorouracil, wich possibly also inhibits thymidilate synthetase.
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© 1976 Plenum Press, New York
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Alberto, P., Medenica, R. (1976). Anhydro-Arabinosyl-Fluorocytosine Hydrochloride: A Phase I Study. In: Hellmann, K., Connors, T.A. (eds) Chemotherapy. Chemotherapy, vol 8. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-4352-3_67
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DOI: https://doi.org/10.1007/978-1-4613-4352-3_67
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