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Electrophysiological Features of Telocytes

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Telocytes

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 913))

Abstract

Telocytes (TCs) are interstitial cells described in multiple structures, including the gastrointestinal tract, respiratory tract, urinary tract, uterus, and heart. Several studies have indicated the possibility that TCs are involved in the pacemaker potential in these organs. It is supposed that TCs are interacting with the neighboring muscular cells and their network contributes to the initiation and propagation of the electrical potentials. In order to understand the contribution of TCs to various excitability mechanisms, it is necessary to analyze the plasma membrane proteins (e.g., ion channels) functionally expressed in these cells. So far, potassium, calcium, and chloride currents, but not sodium currents, have been described in TCs in primary cell culture from different tissues. Moreover, TCs have been described as sensors for mechanical stimuli (e.g., contraction, extension, etc.). In conclusion, TCs might play an essential role in gastrointestinal peristalsis, in respiration, in pregnant uterus contraction, or in miction, but further highlighting studies are necessary to understand the molecular mechanisms and the cell-cell interactions by which TCs contribute to the tissue excitability and pacemaker potentials initiation/propagation.

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Acknowledgments

We are grateful for the financial support received through the program Partnerships in priority areas – PN II, UEFISCDI, Project No. 82/2012. B M Radu has a PhD fellowship from the Italian Ministry of Research (MIUR). DD Banciu is financed by the Sectoral Operational Programme Human Resources Development (SOPHRD), the European Social Fund, and the Romanian Government under the contract number POSDRU/159/1.5/S/141531.

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Authors and Affiliations

  1. Department of Anatomy, Animal Physiology and Biophysics, Faculty of Biology, University of Bucharest, Splaiul Independentei 91-95, Bucharest, 050095, Romania

    Daniel Dumitru Banciu, Adela Banciu & Beatrice Mihaela Radu

  2. Department of Neurological and Movement Sciences, University of Verona, Strada Le Grazie 8, Verona, 37134, Italy

    Beatrice Mihaela Radu

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  1. Daniel Dumitru Banciu
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  2. Adela Banciu
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Correspondence to Beatrice Mihaela Radu .

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  1. Zhongshan Hospital, Fudan University Medical School, Shanghai, China

    Xiangdong Wang

  2. Department of Cellular and Molecular Med, Carol Davila Univ of Medicine&Pharmacy, Bucharest, Romania

    Dragos Cretoiu

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Banciu, D.D., Banciu, A., Radu, B.M. (2016). Electrophysiological Features of Telocytes. In: Wang, X., Cretoiu, D. (eds) Telocytes. Advances in Experimental Medicine and Biology, vol 913. Springer, Singapore. https://doi.org/10.1007/978-981-10-1061-3_19

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