Tumor Dormancy, Quiescence, and Senescence, Volume 2

Aging, Cancer, and Noncancer Pathologies

Editors:

ISBN: 978-94-007-7725-5 (Print) 978-94-007-7726-2 (Online)

Table of contents (28 chapters)

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  1. Front Matter

    Pages i-xxvii

  2. Molecular Mechanisms

    1. Front Matter

      Pages 1-1

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      Chapter

      Pages 3-16

      Asymmetric Dimethylarginine Accelerates Cellular Senescence

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      Chapter

      Pages 17-25

      Membrane-Derived Extracellular Vesicles from Endothelial Progenitor Cells Activate Angiogenesis

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      Chapter

      Pages 27-32

      Induction of P21-Dependent Senescence: Role of NAE Inhibitor MLN4924

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      Chapter

      Pages 33-43

      Regulation of the Novel Senescence Pathway by SKP2 E3 Ligase

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      Chapter

      Pages 45-52

      Oncogene-Induced Senescence: Role of Mitochondrial Dysfunction

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      Chapter

      Pages 53-60

      Interleukin-6 Induces Premature Senescence Involving Signal Transducer and Activator of Transcription 3 and Insulin-Like Growth Factor-Binding Protein 5

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      Chapter

      Pages 61-69

      A Role for the Nuclear Lamina Shape in Cell Senescence and Aging

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      Chapter

      Pages 71-80

      Upregulation of Alpha-2-Macroglobulin in Replicative Senescence

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      Chapter

      Pages 81-88

      Elevation of Ceramide in Senescence: Role of Sphingolipid Metabolism

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      Chapter

      Pages 89-100

      Molecular Signals Underlying Hair Follicle Morphogenesis and Cutaneous Regeneration

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      Chapter

      Pages 101-109

      Role of Chromatin-Remodeling Factor Jun Dimerization Protein 2 (JDP2) in Cellular Senescence

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      Chapter

      Pages 111-119

      Induction of Cellular Senescence: Role of Mitogen-Activated Protein Kinase-Interacting Kinase 1

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      Chapter

      Pages 121-128

      Mechanisms of Premature Cell Senescence

  3. Tumor and Cancer

    1. Front Matter

      Pages 129-129

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      Chapter

      Pages 131-142

      Nuclear Protein Pirin Negates the Cellular Senescence Barrier Against Cancer Development

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      Chapter

      Pages 143-153

      Defects in Chromatin Structure and Diseases

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      Chapter

      Pages 155-164

      The Role of Fibrosis in Tumor Progression and the Dormant to Proliferative Switch

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      Chapter

      Pages 165-178

      Diagnosis of Branchial Cyst Carcinoma: Role of Stem Cells and Dormancy

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      Chapter

      Pages 179-194

      Function of the ING Proteins in Cancer and Senescence

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      Chapter

      Pages 195-206

      Premalignancy and Cellular Senescence

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      Chapter

      Pages 207-217

      Loss of Cdh1 Triggers Premature Senescence in Part via Activation of Both the RB/E2F1 and the CLASPIN/CHK1/P53 Tumor Suppressor Pathways

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