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Defects in Chromatin Structure and Diseases

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Book cover Tumor Dormancy, Quiescence, and Senescence, Volume 2

Part of the book series: Tumor Dormancy and Cellular Quiescence and Senescence ((DOQU,volume 2))

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Abstract

Chromatin is the combination of DNA and other proteins that make up the contents of the nucleus. Chromatin influences all DNA-templated processes including transcription activation and repression, DNA replication and repair. It is now widely appreciated that perturbation of mechanisms regulating chromatin status may have a great impact on cellular physiopathology. In this chapter we describe some genetic diseases related to mutations in genes involved in regulation of chromatin status and also “acquired pathologies” ascribed to defects of ATP-dependent chromatin remodeling and histone post-translational modifications.

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Authors and Affiliations

  1. Department of Experimental Medicine, Section of Biotechnology and Molecular Biology, Second University of Naples, Naples, Italy

    Umberto Galderisi

  2. Institute of Biochemistry of Proteins and Enzymology, C.N.R., Naples, Italy

    Gianfranco Peluso

Authors
  1. Umberto Galderisi
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  2. Gianfranco Peluso
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Corresponding author

Correspondence to Umberto Galderisi .

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Editors and Affiliations

  1. Department of Biological Sciences, Kean University, Room 213, Library Building, Union, New Jersey, USA

    M.A. Hayat

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Galderisi, U., Peluso, G. (2014). Defects in Chromatin Structure and Diseases. In: Hayat, M. (eds) Tumor Dormancy, Quiescence, and Senescence, Volume 2. Tumor Dormancy and Cellular Quiescence and Senescence, vol 2. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-7726-2_15

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