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Drug Delivery to the Central Nervous System

  • Book
  • © 2010

Overview

Editors:
  1. Kewal K. Jain

    1. Jain PharmaBiotech, Basel, Switzerland

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  • Contains detailed protocols of methods of drug delivery to the CNS that are not available in usual publications on the topic
  • Acts as a useful guide for the scientists working in the academia as well as the industry
  • Provides several chapters contain information that is useful for the practicing neurologists
  • Includes supplementary material: sn.pub/extras

Part of the book series: Neuromethods (NM, volume 45)

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Table of contents (15 protocols)

  1. Front Matter

    Pages i-xii
    Download chapter PDF

  2. An Overview of Drug Delivery to the CNS

    • Kewal K. Jain
    Pages 1-13

  3. Receptor-Mediated Transport of Drugs Across the BBB

    • Ji-Ming Feng, Philip C.W. Lui, Jian Yi Li
    Pages 15-34

  4. Disruption of Blood–Brain Barrier by Focused Ultrasound for Targeted Drug Delivery to the Brain

    • Natalia Vykhodtseva
    Pages 35-62

  5. Prediction of Blood–Brain Barrier Penetration by Drugs

    • Kiril Lanevskij, Pranas Japertas, Remigijus Didziapetris, Alanas Petrauskas
    Pages 63-83

  6. Intraparenchymal Delivery and Its Discontents

    • Raghu Raghavan
    Pages 85-135

  7. Intrathecal Drug Delivery by Implanted Pumps

    • Shawn Belverud, Alon Mogilner, Michael Schulder
    Pages 137-153

  8. Intracarotid Drug Delivery: Revisiting the Past or Looking into the Future

    • Shailendra Joshi
    Pages 155-174

  9. Vesicular Systems for Intranasal Drug Delivery

    • Ibrahim A. Alsarra, Amel Y. Hamed, Fars K. Alanazi, Gamal M. El Maghraby
    Pages 175-203

  10. Convection-Enhanced Drug Delivery and Monitoring in a Rat Model

    • Yael Mardor, Zvi Ram
    Pages 205-218

  11. Intrathecal Delivery of Stem Cells to the Spinal Cord

    • Birgit Neuhuber, Itzhak Fischer
    Pages 219-232

  12. CNS Delivery of Peptides Across the BBB Using the Dual-Artery In Situ Brain Perfusion Model

    • Ken A. Witt, Patrick T. Ronaldson, Karin E. Sandoval, Thomas P. Davis
    Pages 233-247

  13. An Engineered Peptide Compound Platform Technology Incorporating Angiopep for Crossing the BBB

    • Reinhard Gabathuler
    Pages 249-260

  14. Adeno-Associated Virus Mediated Gene Therapy in Ischemic Stroke

    • Yongting Wang, Falei Yuan, Guo-Yuan Yang
    Pages 261-276

  15. Use of Mesenchymal Stem Cells for Gene Delivery to Intracranial Glioma

    • Sin-Soo Jeun, Seong Muk Kim, Jung Yeon Lim, Chung Heon Ryu
    Pages 277-290

  16. Convection-Enhanced Drug Delivery to the Brain

    • Dale Ding, Charles W. Kanaly, Martin L. Brady, Stephan Mittermeyer, Raghu Raghavan, John H. Sampson
    Pages 291-318

  17. Back Matter

    Pages 319-321
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Keywords

About this book

Playing an important role in the treatment of neurological disorders, the delivery of drugs to central nervous system (CNS), both administered directly and administered systematically for targeted action, encounters a major challenge in the form of the blood-brain barrier (BBB), which limits the access of drugs to the brain substance. In Drug Delivery to the Central Nervous System, experts in the field present essential methods used to deliver therapeutics across the BBB, both in experimental animals and in humans. In addition to those methods, several overviews of innovative methods and their applications are presented in order to give a glimpse of the future of this research. As a volume in the successful Neuromethods series, this book presents its protocols with the kind of detailed description and implementation advice that is crucial for getting optimal results.

Authoritative and cutting-edge, Drug Delivery to the Central Nervous System serves as an ideal guide to scientists continuing to pursue knowledge of the delicate interactions between pharmaceuticals and the brain.

Editors and Affiliations

  • Jain PharmaBiotech, Basel, Switzerland

    Kewal K. Jain

Bibliographic Information

  • Book Title: Drug Delivery to the Central Nervous System

  • Editors: Kewal K. Jain

  • Series Title: Neuromethods

  • DOI: https://doi.org/10.1007/978-1-60761-529-3

  • Publisher: Humana Totowa, NJ

  • eBook Packages: Springer Protocols

  • Copyright Information: Humana Press 2010

  • Hardcover ISBN: 978-1-60761-528-6Published: 17 December 2009

  • Softcover ISBN: 978-1-4939-6159-7Published: 23 August 2016

  • eBook ISBN: 978-1-60761-529-3Published: 24 December 2009

  • Series ISSN: 0893-2336

  • Series E-ISSN: 1940-6045

  • Edition Number: 1

  • Number of Pages: XII, 321

  • Topics: Neurosciences, Neurobiology, Neurochemistry

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