2011

Ribosomes

Structure, Function, and Dynamics

Editors:

ISBN: 978-3-7091-0214-5 (Print) 978-3-7091-0215-2 (Online)

Table of contents (33 chapters)

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  1. Front Matter

    Pages I-IX

  2. Ribosome structure

    1. Front Matter

      Pages 1-1

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      Book Chapter

      Pages 3-18

      Ribosome crystallography: From early evolution to contemporary medical insights

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      Book Chapter

      Pages 19-30

      Structural studies on decoding, termination and translocation in the bacterial ribosome

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      Pages 31-43

      Structural studies of complexes of the 70S ribosome

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      Pages 45-55

      Interaction of bacterial ribosomes with mRNA and tRNA as studied by X-ray crystallographic analysis

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      Pages 57-64

      Genetic and crystallographic approaches to investigating ribosome structure and function

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      Pages 65-73

      The packing of ribosomes in crystals and polysomes

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      Pages 75-81

      Crystal structure of the eukaryotic 80S ribosome

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      Pages 83-96

      Structure and function of organellar ribosomes as revealed by cryo-EM

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      Pages 97-110

      Modifications of ribosomal RNA: From enzymes to function

  3. Recruiting the ribosome for translation

    1. Front Matter

      Pages 111-111

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      Pages 113-128

      Insights into translation initiation and termination complexes and into the polysome architecture

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      Pages 129-141

      Initiation of bacterial protein synthesis with wild type and mutated variants of initiation factor 2

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      Pages 143-154

      Translation initiation at the root of the cold-shock translational bias

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      Pages 155-169

      Recruiting knotty partners: The roles of translation initiation factors in mRNA recruitment to the eukaryotic ribosome

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      Book Chapter

      Pages 171-185

      The mechanism of ribosome recycling in eukaryotes

  4. Decoding, fidelity, and peptidyl transfer

    1. Front Matter

      Pages 187-187

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      Book Chapter

      Pages 189-198

      The specific interaction between aminoacyl-tRNAs and elongation factor Tu

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      Pages 199-212

      Mechanisms of decoding and peptide bond formation

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      Pages 213-223

      Sense and nonsense recognition by the ribosome

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      Pages 225-235

      Rate and accuracy of messenger RNA translation on the ribosome

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      Book Chapter

      Pages 237-247

      Mutations in 16S rRNA that decrease the fidelity of translation

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      Book Chapter

      Pages 249-261

      Decoding and deafness: Two sides of a coin

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