Abstract
Background
Allergic rhinitis is a common problem affecting between 20 and 25% of the population lowering the quality of life (QOL) more than any other disease. Dyslipidemia is known to impact potently the development of atopy as it promotes proatopic Th2 immunity and allergic inflammation.
Objective
The aim was to test the correlation between severity of allergic rhinitis and dyslipidemia.
Materials and methods
A comparative study carried out on 350 allergic rhinitis patients were subjected to full serum lipid assays, visual analog scale assessing their nasal symptoms, and QOL assessment using a seven-point scale.
Results
Patients were divided into two groups (according to their lipid profile): abnormal dyslipidemia group (33%) and normal lipid profile group (67%).
The abnormal dyslipidemia group showed a more intense allergic rhinitis symptoms compared with the normal lipid profile with poor QOL score (1.97).
Conclusion
Dyslipidemia might play an important role in increasing the severity of allergic rhinitis symptoms with impaired patients’ QOL; therefore, its control could achieve better treatment outcomes.
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References
Min Y-G. The pathophysiology, diagnosis and treatment of allergic rhinitis. Allergy Asthma Immunol Res 2010; 2:65–76.
Poon AW, Goodman CS, Rubin RJ. In vitro and skin test testing for allergy: comparable clinical utility and costs. Am J Manag care 1998; 4:969.
Holgate ST. The role of mast cells and basophils in inflammation. Clin Exp Allergy 2000; 30(Suppl 1):28–32.
Haberal I, Corey JP. The role of leukotrienes in nasal allergy. Otolaryngol Head Neck Surg 2003; 129:274–279.
Chou R, Dana T, Blazina I, Daeges M, Jeanne TL. Statins for prevention of cardiovascular disease in adults: evidence report and systematic review for the US Preventive Services Task Force. JAMA 2016; 316: 2008–2024.
Kimata H. Cholesterol selectively enhances in vitro latex-specific IgE production in atopic dermatitis patients with latex allergy. Life Sci 2005; 76:1527–1532.
Yeh YF, Huang SL. Enhancing effect of dietary cholesterol and inhibitory effect of pravastatin on allergic pulmonary inflammation. J Biomed Sci 2004; 11:599–606.
Serafino-Agrusa L, Spatafora M, Scichilone N. Asthma and metabolic syndrome: current knowledge and future perspectives. World J Clin Cases 2015; 3:285–292.
Alharethy S, Al Wedami M, Syouri F, Alqabbani AA, Baqays A, Mesallam T, Aldrees T. Validation of the Arabic version of the score for allergic rhinitis tool. Ann Saudi Med 2017; 37:357–361.
Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 1972; 18:499–502.
Natarajan S, Glick H, Criqui M, Horowitz D, Lipsitz SR, Kinosian B. Cholesterol measures to identify and treat individuals at risk for coronary heart disease. Am J Prev Med 2003; 25:50–57.
Hanak V, Munoz J, Teague J, Stanley A Jr, Bittner V. Accuracy of the triglyceride to high-density lipoprotein cholesterol ratio for prediction of the low-density lipoprotein phenotype B. Am J Cardiol 2004; 94:219–222.
El Hennawi Del D, Ahmed MR, Farid AM. Psychological stress and its relationship with persistent allergic rhinitis. Eur Arch Otorhinolaryngol 2016; 273:899–904.
Expert Panel on Detection E, Treatment of High Blood Cholesterol in A. Executive Summary of The Third Report of The National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). JAMA 2001; 285:2486–2497.
Craig TJ, McCann JL, Gurevich F, Davies MJ. The correlation between allergic rhinitis and sleep disturbance. J Allergy Clin Immunol 2004; 114:S139–S145.
Ouyang F, Kumar R, Pongracic J, Story RE, Liu X, Wang B, et al. Adiposity, serum lipid levels, and allergic sensitization in Chinese men and women. J Allergy Clin Immunol 2009; 123:940–8. e10.
Schäfer T, Ruhdorfer S, Weigl L, Wessner D, Heinrich J, Döring A, et al. Intake of unsaturated fatty acids and HDL cholesterol levels are associated with manifestations of atopy in adults. Clin Exp Allergy 2003; 33: 1360–1367.
Sarria A, Moreno LA, Mur M, Lázaro A, Lasierra MP, Roda L, et al. Lymphocyte T subset counts in children with elevated low-density lipoprotein levels. Atherosclerosis 1995; 117:119–123.
Pesonen M, Ranki A, Siimes MA, Kallio MJ. Serum cholesterol level in infancy is inversely associated with subsequent allergy in children and adolescents. A 20-year follow-up study. Clin Exp Allergy 2008; 38: 178–184.
Ramaraju K, Krishnamurthy S, Maamidi S, Kaza AM, Balasubramaniam N. “Is serum cholesterol a risk factor for asthma”? Lung India 2013; 30: 295–301.
Stokes KY, Cooper D, Tailor A, Granger DN. Hypercholesterolemia promotes inflammation and microvascular dysfunction: role of nitric oxide and superoxide. Free Radic Biol Med 2002; 33:1026–1036.
Engström G, Lind P, Hedblad B, Stavenow L, Janzon L, Lindgärde F. Effects of cholesterol and inflammation-sensitive plasma proteins on incidence of myocardial infarction and stroke in men. Circulation 2002; 105:2632–2637.
Gupta P, Vijayan VK, Bansal SK. Sphingomyelin metabolism in erythrocyte membrane in asthma. J Asthma 2010; 47:966–971.
Potter PC, Paediatric Levocetirizine Study Group. Efficacy and safety of levocetirizine on symptoms and health related quality of life of children with perennial allergic rhinitis: a double blind, placebo controlled randomized clinical trail. Ann Allergy Asthma Immunol 2005; 95: 175–180.
Gelis N, Prokopakis E, Helidonis E, Velegrakis G. Investigation of the relationship between allergic rhinitis and personality traits. Otolaryngol 2007; 11:138–141.
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Ahmed, M.R., Madian, Y.T., El-Tabbakh, M.T. et al. Correlation between dyslipidemia and severity of allergic rhinitis. Egypt J Otolaryngol 34, 111–115 (2018). https://doi.org/10.4103/ejo.ejo_90_17
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DOI: https://doi.org/10.4103/ejo.ejo_90_17