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An efficient method for the preparation of benzyl γ-ketohexanoates

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Abstract

Twenty acid chlorides, 4-(mono/di-benzyloxy)-4-ketobutanoyl chlorides (Ia–XXa) were synthesised by the reaction of monoesters of succinic acid with thionyl chloride. The product thus obtained (4-benzyloxy-4-ketobutanoyl chlorides) was treated with diethylcadmium to convert it into the corresponding keto-esters (Ib–XXb), the mono/di-benzyl-γ-ketohexanoates, with a good yield. All the compounds thus prepared were characterised by physical, spectroscopic (UV-VIS, IR, 1H NMR, 13C NMR), and mass measurements techniques.

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  1. Department of Chemistry, Gomal University, 29050, Dera Ismail Khan, Pakistan

    Muhammad Iqbal, Imam B. Baloch & Musa K. Baloch

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  1. Muhammad Iqbal
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  2. Imam B. Baloch
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  3. Musa K. Baloch
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Correspondence to Muhammad Iqbal.

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Iqbal, M., Baloch, I.B. & Baloch, M.K. An efficient method for the preparation of benzyl γ-ketohexanoates. Chem. Pap. 67, 444–455 (2013). https://doi.org/10.2478/s11696-012-0282-8

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  • DOI: https://doi.org/10.2478/s11696-012-0282-8

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