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Organoruthenium(II) thiosemicarbazone complexes: synthesis, spectral characterization, DNA binding and DNA cleavage studies

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Central European Journal of Chemistry

Abstract

A series of new ruthenium(II) complexes were synthesized with Schiff bases derived from salicylaldehyde / o-hydroxyacetophenone/ o-vanillin / 2-hydroxy-1-naphthaldehyde with thiosemicarbazide and acetyl furan. They are characterized by elemental analysis, IR, electronic, 1H NMR, 13C NMR and mass spectral studies. The elemental analysis suggests the stoichiometry to be 1:1 (metal:ligand). Four of these complexes were tested for its binding with CT-DNA using absorption spectroscopic studies and two of these complexes exhibit efficient DNA cleavage activity.

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Authors and Affiliations

  1. Post-graduate and Research Department of Chemistry, Sri Ramakrishna Mission Vidyalaya College of Arts and Science, Coimbatore, 641 020, Tamil Nadu, India

    Gunasekaran Raja & Chinnasamy Jayabalakrishnan

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  1. Gunasekaran Raja
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  2. Chinnasamy Jayabalakrishnan
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Correspondence to Chinnasamy Jayabalakrishnan.

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Raja, G., Jayabalakrishnan, C. Organoruthenium(II) thiosemicarbazone complexes: synthesis, spectral characterization, DNA binding and DNA cleavage studies. cent.eur.j.chem. 11, 1010–1018 (2013). https://doi.org/10.2478/s11532-013-0234-3

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  • DOI: https://doi.org/10.2478/s11532-013-0234-3

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