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New Components from Silybum marianum L. Fruits: A Theory Comes True

In Memoriam of Professor Szabolcs Nyiredy (1950–2006)

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An Erratum to this article was published on 10 December 2009

Abstract

The fruits of Silybum marianum L. (milk thistle) has been used for the treatment of hepatic and biliary diseases since ancient times. As separation techniques improved several isomers of silybin—the first determined active compound of milk thistle—have been described. Moreover, a new variety, the white-flowered S. marianum was discovered which contains deoxy-derivatives of some of the flavanolignans found in the purple-flowered variety. Based on this observation Nyiredy presumed that the deoxy-derivatives of all known flavanolignans of the purple-flowered variety are present in the white-flowered one. To prove this prediction several separations have been developed by the use of “PRISMA” principle.

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Acknowledgments

Dr. R. Ohmacht (University of Pécs, Hungary) and Mr. K. Bischoff (Bischoff Chromatography, Leonberg, Germany) are greatlfully acknowledged for the C30 stationary phases.

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Authors and Affiliations

  1. Research Institute for Medicinal Plants, 4 Lupaszigeti Str., 2011, Budakalász, Hungary

    Szabolcs Nyiredy, Zoltán Szűcs & Zsuzsanna Samu

  2. Currently working for OMINCARE CR Ltd, 18 E/4 Táborhegyi Str., 1037, Budapest, Hungary

    Zoltán Szűcs

  3. Department of Organic Chemistry, University of Debrecen, 1 Egyetem Sq., 4010, Debrecen, Hungary

    Sándor Antus

  4. Currently working for Béres Pharmaceuticals Co. Ltd, 2-4 Mikoviny Str., 1037, Budapest, Hungary

    Zsuzsanna Samu

Authors
  1. Szabolcs Nyiredy
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  2. Zoltán Szűcs
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  3. Sándor Antus
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  4. Zsuzsanna Samu
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Corresponding author

Correspondence to Zoltán Szűcs.

Additional information

An erratum to this article can be found at http://dx.doi.org/10.1365/s10337-009-1420-5

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Nyiredy, S., Szűcs, Z., Antus, S. et al. New Components from Silybum marianum L. Fruits: A Theory Comes True. Chroma 68 (Suppl 1), 5–11 (2008). https://doi.org/10.1365/s10337-008-0722-3

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  • DOI: https://doi.org/10.1365/s10337-008-0722-3

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