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Exploring Microstructural Changes in Structural Analogues of Ibuprofen-Hosted In Situ Gelling System and Its Influence on Pharmaceutical Performance

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ABSTRACT

The present work explores inner structuration of in situ gelling system consisting of glyceryl monooleate (GMO) and oleic acid (OA). The system under study involves investigation of microstructural changes which are believed to govern the pharmaceutical performance of final formulation. The changes which are often termed mesophasic transformation were analysed by small angle X-ray scattering (SAXS), differential scanning calorimetry (DSC), rheology and plane polarised light (PPL) microscopy. The current work revealed transformation of blank system from W/O emulsion to reverse hexagonal structure upon addition of structural analogues of ibuprofen. Such transformations are believed to occur due to increased hydrophobic volume within system as probed by SAXS analysis. The findings of SAXS studies were well supported by DSC, rheology and PPL microscopy. The study established inverse relationship between log P value of structural analogues of ibuprofen and the degree of binding of water molecules to surfactant chains. Such relationship had pronounced effect on sol–gel transformation process. The prepared in situ gelling system showed sustained drug release which followed Higuchi model.

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ACKNOWLEDGMENTS

The authors thank Dr. Guruswamy Kumaraswamy, Scientist, Polymer Chemistry, National Chemical Laboratory, Pune for providing facility of small angle X-ray scattering and for extending his cooperation in SAXS data analysis and discussion.2

Conflict of Interest

The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.

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Authors and Affiliations

  1. Poona College of Pharmacy, Department of Pharmaceutics, Bharati Vidyapeeth Deemed University, Erandwane, Pune, Maharashtra, 411 038, India

    Sharvil S. Patil & Kakasaheb R. Mahadik

  2. Polymer Science and Engineering Division, National Chemical Laboratory, Pune, 411 008, India

    Sharvil S. Patil, Edakkal Venugopal & Suresh Bhat

  3. Centre for Pharmaceutical Engineering Science, University of Bradford, Bradford, West Yorkshire, BD7 1DP, UK

    Anant R. Paradkar

Authors
  1. Sharvil S. Patil
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  2. Edakkal Venugopal
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  3. Suresh Bhat
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  4. Kakasaheb R. Mahadik
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  5. Anant R. Paradkar
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Correspondence to Kakasaheb R. Mahadik or Anant R. Paradkar.

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Patil, S.S., Venugopal, E., Bhat, S. et al. Exploring Microstructural Changes in Structural Analogues of Ibuprofen-Hosted In Situ Gelling System and Its Influence on Pharmaceutical Performance. AAPS PharmSciTech 16, 1153–1159 (2015). https://doi.org/10.1208/s12249-015-0308-y

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  • DOI: https://doi.org/10.1208/s12249-015-0308-y

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