Abstract
Currently available information on drug lithiasis usually describes the calculi based on the prescriptions given to the patient, but without a physicochemical characterization of the calculi themselves. We here have applied different, complementary, physicochemical techniques for a complete characterization of an unusual urolithiasis calculus. The calculus was characterized using powder X-ray diffraction, infrared spectroscopy, mass spectrometry, 1H-NMR spectroscopy, and scanning electron microscopy. The precise nature of the calculus was identified, being formed by N4-acetylsulfadiazine, so being related to the drugs prescribed to the patient. Analytical techniques widely used in laboratories of Materials Chemistry have proven to be useful tools for characterizing the chemical nature of unusual urolithiasis.
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REFERENCES
Duday H, Clottes J, Mercadier H, Rouzaud F, Zammit J. Un calcul urinaire provenant du dolmen de la Bertrandoune á Praussac (Lot France). Actes du 3ème Congrès Européen de l’Association de Paléopathologie, Caen (France); 1980. p. 87–89.
Jungers P, Daudon M, Le Duc A, editors. Lithiase urinaire. France: Flammarion; 1989.
Scheider HJ. Urolithiasis: etiology · diagnosis (handbook of urology), vol. 17/I. Berlin: Springer; 1985.
Pinto B. Litiasis renal. 2ath ed. Barcelona: Ediciones Científicas y Técnicas; 1993.
Hidalgo A, Carmona P, Bellanato J, Santos M, García Ramos JV, Cifuentes Delatte L. Análisis de cálculos urinarios por espectroscopía infrarroja y Raman. Madrid: Instituto de Optica Daza de Valdés, CSIC; 1983.
Nadler RB, Rubinstein JN, Eggener SE, Loor MM, Smith ND. The etiology of urolithiasis in HIV infected patients. J Urol. 2003;169:475–7.
Bauer J, Spanton S, Henry R, Quick J, Dziki W, Porter W, Morris J. Ritonavir: an extraordinary example of conformational polymorphism. Pharm Res. 2001;18:859–66.
Sinha S, Ali M, Baboota S, Ahuja A, Kumar A, Ali J. Solid dispersion as an approach for bioavailability enhancement of poorly water-soluble drug ritonavir. AAPS PharmSciTech. 2010;11:518–27.
Daudon M. Recueil des spectres infra-rouges des calculs de l’arbre urinaire et des voies biliaires et des cristalluries. Paris: Centre de Recherches et d’Information Scientifique et Technique Appliquées aux Lithiases; 1994.
Prieto MJ, Bacigalupe D, Pardini O, Amalvy JI, Venturini C, Morilla MJ, Romero EL. Nanomolar cationic dendrimeric sulfadiazine as potential antitoxoplasmic agent. Int J Pharm. 2006;326:160–8.
Woolley Jr JL, Sigel CW. Metabolism and disposition by the rat of 35S-sulfadiazine alone and in the presence of trimethoprim. Drug Metab Dispos. 1979;7:94–9.
Nelson DL, Cox MM. Lehninger principles of biochemistry. 5th ed. New York: W.H. Freeman; 2008.
Gibson GG, Skett P. Introduction to drug metabolism. 3rd ed. Cheltenham: Nelson Thornes; 2001.
Daudon M, Jungers P. Drug-induced renal calculi: epidemiology, prevention and management. Drugs. 2004;64:245–75.
Servais A, Daudon M, Knebelman B. Drug-induced renal calculi. Ann Urol. 2006;40:57–68.
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Cuervo, C., González, J., Rives, V. et al. Characterization of a Sulfadiazine-Induced Lithiasis Calculus by Physicochemical Techniques. AAPS PharmSciTech 14, 128–132 (2013). https://doi.org/10.1208/s12249-012-9892-2
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DOI: https://doi.org/10.1208/s12249-012-9892-2