Abstract
Any decision in clinical practice needs to evaluate both reliability (precision) and validity (accuracy) of a diagnostic test. Without knowledge about the reliability, any judgment would be wrong. In diagnostic accuracy research, it is essential to evaluate the diagnostic added value of a test, since a diagnostic accuracy of a single test might be excellent, however for clinical purposes it can be worthless. Like evaluating discrimination, it would be possible to estimate the diagnostic added value by applying ROC of diagnostic model with and without test results in the model.
To the Editor.
I read the paper from Zhihui Fu et al. published in J Cardiothorac Surg [1]. The aim of the study was to assess the diagnostic value of D-dimer with simplified Geneva score (SGS) pre-test in the diagnosis of pulmonary embolism (PE). In a retrospective analysis, 1035 patients with suspected PE were recruited. All enrolled patients were grouped according to the computed tomographic pulmonary angiogram (CTPA) results: PE patients and non-PE patients. Then, receiver operating characteristic (ROC) curve were constructed to determine the optimal D-dimer cutoff point value which is based on Yonden’s index (YI).
Although I appreciate this significant study, I would like to raise some methodological issues that can affect the interpretation of results. First, any decision in clinical practice needs to evaluate both reliability (precision) and validity (accuracy) of CTPA. Without knowledge about the reliability, any judgment would be wrong [2,3,4,5,6]. Second, in diagnostic accuracy research, it is essential to evaluate the diagnostic added value of CTPA, since a diagnostic accuracy of a single test might be excellent, however for clinical purposes it can be worthless. Like evaluating discrimination, it would be possible to estimate the diagnostic added value by applying ROC of diagnostic model with and without CTPA [2, 7, 8]. Hence, we suggest the authors to estimate both diagnostic added value and reliability of the CTPA by an appropriate method.
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Abbreviations
- SGS:
-
Simplified Geneva Score
- CTPA:
-
Computed Tomographic Pulmonary Angiogram
- ROC:
-
Receiver Operating Characteristic
- YI:
-
Yonden’s Index
References
Zhihui F, Zhuang X, He Y, Huang H, Guo W. The diagnostic value of D-dimer with simplified Geneva score (SGS) pre-test in the diagnosis of pulmonary embolism (PE). J Cardiothorac Surg. 2020 Jul 20;15(1):176.
Grobbee DE, Hoes AW. Clinical epidemiology: Jones & Bartlett Publishers; 2014.
Sabour S. Reproducibility of dynamic Scheimpflug-based pneumotonometer and its correlation with a dynamic bidirectional pneumotonometry device: methodological issues. Cornea. 2015;34:14–5.
Sabour S, Rutten A, van der Schouw YT, Atsma F, Grobbee DE, Mali WP, et al. Inter-scan reproducibility of coronary calcium measurement using multi detector-row computed tomography (MDCT). Eur J Epidemiol. 2007;22:235–43.
Sabour S. Reproducibility of semi-automatic coronary plaque quantification in coronary CT angiography with sub-mSv radiation dose; common mistakes. J Cardiovasc Comput Tomogr. 2016;10:21–2.
Naderi M, Sabour S. Reproducibility of diagnostic criteria associated with atypical breast cytology: a methodological issue. Cytopathology. 2018;29:396.
Sabour S. A common mistake in assessing the diagnostic value of a test: failure to account for statistical and methodologic issues. J Nucl Med. 2017;58:1182–3.
Sabour S, Ghassemi F. Accuracy, validity, and reliability of the infrared optical head tracker (IOHT). Invest Ophthalmol Vis Sci. 2012;53:4776.
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Sabour, S. Comment on “The diagnostic value of D-dimer with simplified Geneva score (SGS) pre-test in the diagnosis of pulmonary embolism (PE)”. J Cardiothorac Surg 15, 246 (2020). https://doi.org/10.1186/s13019-020-01301-0
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DOI: https://doi.org/10.1186/s13019-020-01301-0