Background

The vast majority of patients affected by SARS-COV-2 infection present flu-like symptoms [1, 2]. However, as the pandemic evolves, a broader, diverse and unknown spectrum of symptoms can be observed. An increasing number of patients with neurological symptoms have been reported [3,4,5,6]. These manifestations can go from mild and common symptoms such as anosmia or ageusia, to severe ones and less common such as a cerebrovascular accident [3,4,5,6]. Symptoms of extrapulmonary disease could be explained by the damage of the endothelial tissue caused by the virus [7].

With this new virus, we do not just face new and unknown manifestations, but also how different patient groups are affected by SARS-COV-2 infection, such as pregnant women. That is the reason why we present a case report of a pregnant woman infected with SARS-COV-2 who showed seizures and sudden blindness.

Case presentation

We describe 35-year-old pregnant women with just hypothyroidism treated with thyroxin 88 μg every 24 h as personal background and optimal blood pressure control during pregnancy, in her 40 weeks and 6 days of gestation. Pregnancy has been controlled by hospital protocols with no evidence of obstetric risk factors.

With no clinical manifestations the previous days, the patient was brought to our hospital due to generalized tonic-clonic seizures at home. The first suspicion was of eclampsia, and that was why an emergency C-section was performed. The same day the diagnosis of SARS-COV-2 infection was confirmed by immunoglobulin rapid test (I-RT) and nasopharyngeal Polymerase Chain Reaction (PCR) of the virus. The only abnormal results in the blood test at arrival to the hospital were Lactic Acid Dehydrogenase (LDH) of 336 UI/I and D-Dimer of 5781 ng/ml. During her hospitalization, the blood creatinine values were within the normal range. The procedure was performed with general anaesthesia. Induction was made with propofol 200 mg and rocuronium 100 mg. After birth, we started fentanyl 300 μg and sevoflurane for maintenance of the anaesthesia without complications, completing postoperative care in the intensive care unit. After C-section, we initiated treatment with intravenous magnesium sulphate aiming levels between 4 to 6 mg/dl, she developed high blood pressure with values of Systolic pressure higher than 160 mmHg and diastolic pressure higher than 100 mmHg and we started intravenous labetalol 60 mg every hour for blood pressure control. After that, we introduced oral treatment with labetalol 100 mg every 12 h, captopril 25 mg every 12 h and amlodipine 5 mg every 12 h. It allowed lowering the dose of intravenous labetalol progressively until suspension. Twenty-four hours after C-section, the risk index Soluble Fms-Like Tyrosine kinase-1/ Placental Growth Factor (sFlt-1/PlGF) was 51.4988.

Few hours after C-section, the patient showed sudden blindness without other neurologic symptoms. Regarding to visual acuity: She could appreciate lights and shadows, being impossible with her degree of vision loss to achieve a low vision testing such as counting fingers or noticing moving objects with both eyes. Also, she had absence of the bilateral menace reflex (blink-to-threat reflex). The rest of the cranial nerves and neurological exam showed no pathological findings.

Due to these findings, a brain CT-scan and CT-angiography were performed, existing no anomalies in these tests. We notified the case to the Neurology department who suspected posterior reversible leukoencephalopathy as a primary diagnosis, although there was no nuclear magnetic resonance confirmation. Because of this suspicion, we began treatment with subcutaneous enoxaparin 40 mg every 24 h.

The vision of the patient was recovered progressively during the first 48 h and the next day she was moved to a COVID-19 hospitalization area with antithrombotic and antihypertensive treatment. Currently, she has not any neurological symptoms and normal blood pressure without treatment.

Discussion and conclusion

The main manifestation of COVID-19 is influenza-like symptomatology but there are others such as anosmia or ageusia [1,2,3,4,5,6]. Not much has been said about different affectations in pregnant women or if this virus has any impact on the foetus. But it is important to have in mind that other coronaviruses such as SARS or Middle East Respiratory Syndrome (MERS) seems to increase complications such as preeclampsia [8].

In this case, we have a pregnant woman with positive COVID-19 I-RT and PCR that shows severe neurological symptoms. At first, the suspicion was eclampsia missing a diagnosis of preeclampsia during pregnancy, even when she had all the usual controls of pregnancy done and correct. The patient did not present any blood pressure alterations during those controls or in the ultrasound of the placenta. Also, she did not present any other suggestive clinic of preeclampsia. Twenty-four hours after C-section a risk index sFlt-1/PlGF was requested resulting high (51.4988) for diagnosis of preeclampsia in the next 4 weeks, but low for an imminent complication. The half-life of sFlt-1 is estimated in 1,4 days, while the half-life of PlGF is 3,7 [9], therefore the risk would not change. We also have the suspicion of neurological manifestations of COVID-19, where seizures are present in 0,7% of the cases [10], but she did not have any other clinical symptoms of COVID-19 such as headaches, ageusia or anosmia. Seizures are associated with previous history of cognitive impairment, older age, higher creatine Kinase levels and higher C-reactive protein [10].

SARS-COV-2 has been identified in brain endothelial cells [3]. Eclampsia, posterior reversible leukoencephalopathy and COVID-19 share a common pathophysiology affecting endothelial tissue [11, 12]. Therefore, we consider that SARS-COV-2 infection during pregnancy could increase the risk of suffering posterior reversible leukoencephalopathy or preeclampsia/eclampsia syndrome.

To conclude, we believe SARS-COV-2 infection could promote brain endothelial damage, triggering the cited neurological complications in our patient. To our knowledge, this is the first report of a patient with COVID-19 presenting preeclampsia associated with eclampsia versus posterior reversible leukoencephalopathy without alarm signs or symptoms. We consider further studies are needed to confirm that SARS-COV-2 infection is a risk factor to develop neurological complications of pregnant woman during pregnancy.