Pharmacoenvironmentology – a component of pharmacovigilance
According to WHO, Pharmacovigilance activities are done to monitor detection, assessment, understanding and prevention of any obnoxious adverse reactions to drugs at therapeutic concentration on animal and human beings. However, there is also a growing focus among scientists and environmentalists about the impact of drugs on environment and surroundings. The existing term 'Ecopharmacology' is too broad and not even defined in a clear manner. The term 'Pharmacoenvironmentology' seeks to deal with the environmental impact of drugs given to humans and animals at therapeutic doses.
- Hignite C, Azarnoff DL: Drugs and drug metabolites as environmental contaminants: chlorophenoxyisobutyrate and salicylic acid in sewage water effluent. Life Sciences 1977, 20:337–341. CrossRef
- Zuccato Ettore, Calamari Davide, Natangelo Marco, Fanelli Roberto: Presence of therapeutic drugs in the environment. The lancet 2000, 355:1789–1790. CrossRef
- Pawlowski Sascha, Ternes Thomas, Bonerz Martin, et al.: Combined in Situ and in Vitro Assessment of the Estrogenic Activity Sewage and Surface Water Samples. Toxicological Sciences 2003, 75:57–65. CrossRef
- Cleuvers M: Mixture toxicity of the anti-inflammatory drugs diclofenac, ibuprofen, naproxen and acetylsalicylic acid. Ecotoxicol Environ Saf 2004, 59:309–315. CrossRef
- Huggett DB, Brooks BW, Peterson B, Foran CM, Schlenk D: Toxicity of Select Beta Adrenergic Receptor-Blocking Pharmaceuticals (B-Blockers) on Aquatic Organisms. Archive of Environmental Contamination and Toxicology 2002,43(2):229–235. CrossRef
- Christensen FM: Pharmaceuticals in the environment – a human risk? Regul Toxicol Pharmacol 1998, 28:212–221. CrossRef
- Woodward KN: Veterinary Pharmacovigilance. Part 3. Adverse effects of veterinary medicinal products in animals and on the environment. J Vet Pharmacol Therap 2005, 28:171–184. CrossRef
- Boxall ABA, Kolpin DW, Halling-Sorensen B, Tolls J: Are veterinary medicines causing environmental risk? Environ Sci Techno 2003, 37:286–294A. CrossRef
- Richard WilliamsT, Cook JonC: Exposure to Pharmaceuticals Present in the Environment. Drug Information Journal 2007,41(2):133–141.
- Prakash V: Status of vultures in Keoladeo National Park, Bharatpur, Rajasthan with special reference to population crash in Gyps species. J Bombay Natural History Society 1999, 96:365–378.
- Oaks JL, Gilbert M, Virani MZ, Watson RT, Meteyer CU, Rideout B, Shivaprasad HL, Ahmed S, Chaudhry MJI, Arshad M, Mahmood S, Ali A, Khan AA: Diclofenac residues as a cause of population decline of White-backed Vultures in Pakistan. Nature 2004, 427:630–633. CrossRef
- Rahman SZ: Impact of Human Medicines on Environment – A New Emerging Problem. Population Envis 2006,3(2):3–4.
- Aherne GW, Briggs R: The relevance of the presence of certain synthetic steroids in the aquatic environment. J Pharm Pharmacol 1989, 41:735–736.
- Rahman SZ, Khan RA: Environmental Pharmacology – A New Discipline (Editorial). Indian J Pharmacol 2006,34(4):1–2.
- Kummerer Klaus, Velo Giampaolo: Ecopharmacology: A New Topic of Importance in Pharmacovigilance. Drug Safety 2006,29(5):371–373. CrossRef
- Daughton CG, Ternes TA: Pharmaceuticals and Personal Care Products in the Environment: Agents of Subtle Change? Environmental Health Perspectives 1999,107(Suppl 6):907–938. CrossRef
- Raloff Janet: Drugged Waters. Science News 1998,153(12):187–189. CrossRef
- EMEA Guideline on the environmental Risk Assessment of medicinal Products for Human Use [http://www.emea.eu.int/pdfs/human/swp/444700en.pdf] December 13, 2006
- Woodward KN: Veterinary pharmacovigilance. Part 2. Veterinary pharmacovigilance in practice – the operation of a spontaneous reporting scheme in a European Union country – the UK, and schemes in other countries. J Vet Pharmaco Therap 2005, 28:149–170. CrossRef
- Sumpter JohnP: Environmental Effects of Human Pharmaceuticals. Drug Information Journal 2007,41(2):143–147.
- Pharmacoenvironmentology – a component of pharmacovigilance
- Open Access
- Available under Open Access This content is freely available online to anyone, anywhere at any time.
- Online Date
- July 2007
- Online ISSN
- BioMed Central
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