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Identification and quantitative determination of baclofen in human blood by HPLC with mass spectrometry detection

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A method of identification and quantitative determination of baclofen in blood by HPLC with mass spectrometry detection has been developed. It is characterized by high sensitivity, specificity, linearity, accuracy, reproducibility, and a low detection for quantitative determination. The method has been used for diagnostics of acute baclofen poisoning in patients.

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Authors and Affiliations

  1. Siberian Federal University, Krasnoyarsk, Russia

    O. A. Dukova & A. A. Efremov

  2. Krasnoyarsk Regional Bureau of Forensic Medical Expertise, Krasnoyarsk, Russia

    O. A. Dukova & E. V. Suvorova

  3. Central Research Laboratory, Voyno-Yasenetsky Krasnoyarsk Medical University, Krasnoyarsk, Russia

    M. Yu. Kotlovsky & A. A. Pokrovsky

  4. Karpovich Municipal Clinical Emergency Hospital no. 6, Krasnoyarsk, Russia

    T. G. Shivrina

  5. Siberian Medical University, Moscow tract 2, bld. 7, block A, Tomsk, 634050, Russia

    E. A. Krasnov

Authors
  1. O. A. Dukova
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  2. M. Yu. Kotlovsky
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  3. A. A. Pokrovsky
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  4. E. V. Suvorova
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  5. T. G. Shivrina
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  6. E. A. Krasnov
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  7. A. A. Efremov
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Corresponding author

Correspondence to E. A. Krasnov.

Additional information

Original Russian Text © O.A. Dukova, M.Yu. Kotlovsky, A.A. Pokrovsky, E.V. Suvorova, T.G. Shivrina, E.A. Krasnov, A.A. Efremov, 2015, published in Biomeditsinskaya Khimiya.

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Dukova, O.A., Kotlovsky, M.Y., Pokrovsky, A.A. et al. Identification and quantitative determination of baclofen in human blood by HPLC with mass spectrometry detection. Biochem. Moscow Suppl. Ser. B 9, 137–142 (2015). https://doi.org/10.1134/S1990750815020067

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  • DOI: https://doi.org/10.1134/S1990750815020067

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