Abstract
Parameters reflecting oxidative stress (OS) have been studied in 37 patients with alcoholic liver disease (ALD) during admission to the hospital and 2 weeks after the beginning of therapy. The patients were divided into 3 groups: alcoholic hepatitis (AH), alcoholic cirrhosis with hepatic insufficiency (the group C by the Child-Paquet scale) and terminal stage patients (subsequently died). All patients were characterized by a significant increase in plasma products of lipid peroxidation (conjugated diene and malondialdehyde) and a decrease of the ceruloplasmin level. The coefficient C OS significantly exceeded normal values both on admission and after the 2-week course of traditional therapy. This suggests an important role of the OS with ALD.
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Original Russian Text © L.F. Panchenko, B.V. Davydov, N.N. Terebilina, V.Yu. Baronets, A.S. Zhuravleva, 2014, published in Biomeditsinskaya Khimiya.
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Panchenko, L.F., Davydov, B.V., Terebilina, N.N. et al. Oxidative stress in the alcoholic liver disease. Biochem. Moscow Suppl. Ser. B 8, 73–76 (2014). https://doi.org/10.1134/S1990750814010120
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DOI: https://doi.org/10.1134/S1990750814010120