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Synchrotron X-ray diffraction study of the structure of oral stratum corneum model lipid membranes

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Abstract

Membranes modeling the lipid fraction of the mucous membrane of the human oral cavity have been studied by X-ray synchrotron diffraction. Ternary systems, composed of a mixture of sphingomyelin, dipalmitoylphosphatidylcholine, and dipalmitoylphosphatidylethanolamine with component weight ratios of 1: 2: 2 and 1: 2: 1, have lamellar structures in the gel phase at the physiological temperature (37°C). An inverted hexagonal phase is formed in the system with 40% dipalmitoylphosphatidylethanolamine in the temperature range of 60–70°C. This phase coexists with the liquid-crystalline lamellar phase in a narrow temperature range and completely surpresses the lamellar phase with an increase in temperature to 80°C. Multi-component oral stratum corneum membranes are characterized by several lamellar phases at 20–37°C and the coexistence of one or several lamellar phases with inverted hexagonal phase at 80–90°C.

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Authors and Affiliations

  1. Joint Institute for Nuclear Research, Dubna, Moscow oblast, 141980, Russia

    N. Yu. Ryabova

  2. Skobeltsyn Institute of Nuclear Physics, Moscow State University, Moscow, 119234, Russia

    N. Yu. Ryabova

  3. National Research Centre “Kurchatov Institute”, Moscow, 123182, Russia

    A. Yu. Gruzinov & A. V. Zabelin

Authors
  1. N. Yu. Ryabova
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  2. A. Yu. Gruzinov
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  3. A. V. Zabelin
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Correspondence to N. Yu. Ryabova.

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Original Russian Text © N.Yu. Ryabova, A.Yu. Gruzinov, A.V. Zabelin, 2014, published in Kristallografiya, 2014, Vol. 59, No. 1, pp. 129–136.

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Ryabova, N.Y., Gruzinov, A.Y. & Zabelin, A.V. Synchrotron X-ray diffraction study of the structure of oral stratum corneum model lipid membranes. Crystallogr. Rep. 59, 117–124 (2014). https://doi.org/10.1134/S106377451401012X

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  • DOI: https://doi.org/10.1134/S106377451401012X

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