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Early morphological and functional changes in the GABAergic system of hippocampus in the rat lithium-pilocarpine model of epilepsy

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Abstract

We studied early alterations in the GABAergic system of the rat hippocampus in the lithium–pilocarpine model of epilepsy. Twenty-four hours after the pilocarpine treatment, a decrease in the number of calretinin-positive interneurons was observed in the CA1 field of the hippocampus, whereas the number of parvalbumin-positive interneurons remained unchanged. The decreased levels of the GABA-synthesizing enzyme glutamic acid decarboxylase (GAD67) and the membrane GABA transporter GAT1 were revealed using Western blot analysis. These data indicate an altered excitation/inhibition balance in the hippocampus with excitation dominance.

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Authors and Affiliations

  1. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St. Petersburg, Russia

    V. B. Karyakin, D. S. Vasil’ev, I. A. Zhuravin, A. V. Zaitsev & L. G. Magazanik

  2. St. Petersburg State University, St. Petersburg, Russia

    V. B. Karyakin & L. G. Magazanik

Authors
  1. V. B. Karyakin
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  2. D. S. Vasil’ev
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  3. I. A. Zhuravin
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  4. A. V. Zaitsev
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  5. L. G. Magazanik
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Corresponding author

Correspondence to L. G. Magazanik.

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Original Russian Text © V.B. Karyakin, D.S. Vasil’ev, I.A. Zhuravin, A.V. Zaitsev, L.G. Magazanik, 2017, published in Doklady Akademii Nauk, 2017, Vol. 472, No. 2, pp. 230–233.

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Karyakin, V.B., Vasil’ev, D.S., Zhuravin, I.A. et al. Early morphological and functional changes in the GABAergic system of hippocampus in the rat lithium-pilocarpine model of epilepsy. Dokl Biol Sci 472, 4–7 (2017). https://doi.org/10.1134/S0012496617010045

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  • DOI: https://doi.org/10.1134/S0012496617010045

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