Skip to main content

Advertisement

SpringerLink
Log in

Tiling-resolution array-CGH reveals the pattern of DNA copy number alterations in acute lymphoblastic leukemia with 21q amplification: the result of telomere dysfunction and breakage/fusion/breakage cycles?

  • Letter to the Editor
  • Published:
Leukemia Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1
Figure 2

References

  1. Harewood L, Robinson H, Harris R, Al-Obaidi MJ, Jalali GR, Martineau M et al. Amplification of AML1 on a duplicated chromosome 21 in acute lymphoblastic leukemia: a study of 20 cases. Leukemia 2003; 17: 547–553.

    Article  CAS  PubMed  Google Scholar 

  2. Soulier J, Trakhtenbrot L, Najfeld V, Lipton JM, Mathew S, Avet-Loiseau H et al. Amplification of band q22 of chromosome 21, including AML1, in older children with acute lymphoblastic leukemia: an emerging molecular cytogenetic subgroup. Leukemia 2003; 17: 1679–1682.

    Article  CAS  PubMed  Google Scholar 

  3. Harrison CJ, Moorman AV, Barber KE, Broadfield ZJ, Cheung KL, Harris RL et al. Interphase molecular cytogenetic screening for chromosomal abnormalities of prognostic significance in childhood acute lymphoblastic leukaemia: a UK Cancer Cytogenetics Group Study. Br J Haematol 2005; 129: 520–530.

    Article  PubMed  Google Scholar 

  4. Strefford JC, van Delft FW, Robinson HM, Worley H, Yiannikouris O, Selzer R et al. Complex genomic alterations and gene expression in acute lymphoblastic leukemia with intrachromosomal amplification of chromosome 21. Proc Natl Acad Sci USA 2006; 103: 8167–8172.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Moorman AV, Richards SM, Robinson HM, Strefford JC, Gibson BE, Kinsey SE et al. Prognosis of children with acute lymphoblastic leukaemia (ALL) and intrachromosomal amplification of chromosome 21 (iAMP21). Blood 2006, [E-pub ahead of print].

  6. Baldus CD, Liyanarachchi S, Mrozek K, Auer H, Tanner SM, Guimond M et al. Acute myeloid leukemia with complex karyotypes and abnormal chromosome 21: Amplification discloses overexpression of APP, ETS2, and ERG genes. Proc Natl Acad Sci USA 2004; 101: 3915–3920.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Schoumans J, Johansson B, Corcoran M, Kuchinskaya E, Golovleva I, Grander D et al. Characterisation of dic(9;20)(p11–13;q11) in childhood B-cell precursor acute lymphoblastic leukaemia by tiling resolution array-based comparative genomic hybridisation reveals clustered breakpoints at 9p13.2 and 20q11.2. Br J Haematol 2006; 135: 492–499.

    Article  PubMed  Google Scholar 

  8. Sabatier L, Ricoul M, Pottier G, Murnane JP . The loss of a single telomere can result in instability of multiple chromosomes in a human tumor cell line. Mol Cancer Res 2005; 3: 139–150.

    Article  CAS  PubMed  Google Scholar 

Download references

Acknowledgements

We thank The Swedish Cancer Society, The Swedish Children's Cancer Foundation, The Swedish Medical Research Council and The Mary Bevé Foundation for financial support of this study.

Author information

Authors and Affiliations

  1. Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden

    E Kuchinskaya, A Nordgren, J Schoumans, M Nordenskjöld & E Blennow

  2. Department of Woman and Child Health, Karolinska Institutet, Stockholm, Sweden

    M Heyman & S Söderhäll

  3. Department of Oncology and Pathology, Karolinska Institutet, Stockholm, Sweden

    M Corcoran & D Grandér

  4. Department of Oncology, University Hospital, Lund, Sweden

    J Staaf & Å Borg

Authors
  1. E Kuchinskaya
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. A Nordgren
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. M Heyman
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. J Schoumans
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. M Corcoran
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. J Staaf
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Å Borg
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. S Söderhäll
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. D Grandér
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. M Nordenskjöld
    View author publications

    You can also search for this author in PubMed Google Scholar

  11. E Blennow
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to E Kuchinskaya.

Additional information

Supplementary Information accompanies the paper on the Leukemia website (http://www.nature.com/leu)

Supplementary information

Rights and permissions

Reprints and permissions

About this article

Cite this article

Kuchinskaya, E., Nordgren, A., Heyman, M. et al. Tiling-resolution array-CGH reveals the pattern of DNA copy number alterations in acute lymphoblastic leukemia with 21q amplification: the result of telomere dysfunction and breakage/fusion/breakage cycles?. Leukemia 21, 1327–1330 (2007). https://doi.org/10.1038/sj.leu.2404628

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/sj.leu.2404628

  • Springer Nature Limited

This article is cited by

Search

Navigation