Skip to main content

Advertisement

SpringerLink
Log in

Absence of microsatellite instability during the progression of chronic myelocytic leukemia

  • Brief Communication
  • Published:
Leukemia Submit manuscript

Abstract

Microsatellites are highly polymorphic, short-tandem repeat sequences dispersed throughout the genome. To test the occurrence of genetic instability in the progression of chronic myelocytic leukemia (CML), we studied microsatellite instability (MSI) in 17 patients with CML. The DNAs from both chronic phase and blast crisis were analyzed at 10 loci. No MSI was observed in any of the 17 cases of blast crisis. These results indicate that MSI is rare and is not associated with progression to blast crisis in most cases of CML.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Author information

Authors and Affiliations

  1. Department of Medicine, Cedars-Sinai Medical Center, UCLA School of Medicine, USA

    N Mori, S Takeuchi, T Tasaka & HP Koeffler

  2. Department of Hematology, Tokyo Women’s Medical College, Japan

    N Mori & H Mizoguchi

  3. Department of Clinical Pathology, Cedars-Sinai Medical Center, UCLA School of Medicine, USA

    S Lee & S Spira

  4. Department of Hematology, Hadassah Medical Organization, Israel

    D Ben-Yehuda

  5. Department of Hematology/Oncology, UCLA School of Medicine, USA

    G Schiller

Authors
  1. N Mori
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. S Takeuchi
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. T Tasaka
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. S Lee
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. S Spira
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. D Ben-Yehuda
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. H Mizoguchi
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. G Schiller
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. HP Koeffler
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Mori, N., Takeuchi, S., Tasaka, T. et al. Absence of microsatellite instability during the progression of chronic myelocytic leukemia. Leukemia 11, 151–152 (1997). https://doi.org/10.1038/sj.leu.2400524

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1038/sj.leu.2400524

  • Springer Nature Limited

Keywords

This article is cited by

Search

Navigation