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MITOPHAGY

Enhanced brain mitophagy slows systemic aging

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Compromised clearance of dysfunctional mitochondria, through the process of mitophagy, has garnered attention as an essential contributor to aging and neurodegeneration. Schmid and colleagues1 reveal that genetic enhancement of mitophagy via neuronal overexpression of BNIP3 alleviates brain aging and prolongs healthspan in fruit flies.

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Fig. 1: Neuronal overexpression of BNIP3 delays systemic aging via mitophagy induction in fruit flies.

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Authors and Affiliations

  1. Department of Clinical Molecular Biology, University of Oslo and Akershus University Hospital, Lørenskog, Norway

    Sofie Lautrup & Evandro F. Fang

Authors
  1. Sofie Lautrup
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  2. Evandro F. Fang
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Corresponding author

Correspondence to Evandro F. Fang.

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Competing interests

E.F.F. has a CRADA arrangement with ChromaDex (USA) and is consultant to Aladdin Healthcare Technologies (UK and Germany), the Vancouver Dementia Prevention Centre (Canada), Intellectual Labs (Norway) and MindRank AI (China).

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Lautrup, S., Fang, E.F. Enhanced brain mitophagy slows systemic aging. Nat Aging 2, 463–464 (2022). https://doi.org/10.1038/s43587-022-00226-8

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