The mechanism underlying CCG-repeat expansions in patients with fragile X premutation is not well understood. Using a new experimental system in mammalian cells, a study in this issue reports that break-induced replication has a role in CGG-repeat instability.
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Deshpande, M., Gerhardt, J. Break-induced replication sparks CGG-repeat instability. Nat Struct Mol Biol 25, 643–644 (2018). https://doi.org/10.1038/s41594-018-0103-z
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DOI: https://doi.org/10.1038/s41594-018-0103-z
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