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EMBRYOLOGY

The long and winding road of development: a coordinated song of transcription factors

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A four-dimensional single-cell atlas of transcription factor expression in Caenorhabditis elegans allows the identification of novel regulators of embryo development and the generation of molecular models of cell fate specification.

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Fig. 1: Ma et al.3 generate a spatiotemporal molecular map of C. elegans development by recording the expression of 266 transcription factors during the course of 7 hours.

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Acknowledgements

A.M. is a recipient of an LMB Cambridge Scholarship (Cambridge Trust). Work in the laboratory of M.N.S. is funded by the Medical Research Council (MRC, award number MC_UP_1201/24), the European Molecular Biology Organisation (Advanced EMBO fellowship) and the NC3Rs (International 3Rs prize).

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  1. MRC Laboratory of Molecular Biology, Cambridge, UK

    Aly Makhlouf & Marta N. Shahbazi

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  1. Aly Makhlouf
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  2. Marta N. Shahbazi
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Correspondence to Marta N. Shahbazi.

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Makhlouf, A., N. Shahbazi, M. The long and winding road of development: a coordinated song of transcription factors. Nat Methods 18, 866–867 (2021). https://doi.org/10.1038/s41592-021-01219-y

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