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NEURODEGENERATION

Biomarkers for Alzheimer’s disease beyond amyloid and tau

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Two new biomarkers for Alzheimer’s disease include one in the blood that relates to neurodegeneration and another that reflects blood–brain barrier dysfunction and is identifiable in cerebrospinal fluid analysis.

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Fig. 1: New early biomarkers for neurodegeneration.

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Authors and Affiliations

  1. Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden

    Henrik Zetterberg

  2. Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden

    Henrik Zetterberg

  3. Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, UK

    Henrik Zetterberg

  4. UK Dementia Research Institute at UCL, London, UK

    Henrik Zetterberg

  5. Dementia Research Centre, Box 16, National Hospital for Neurology and Neurosurgery, London, UK

    Jonathan M. Schott

Authors
  1. Henrik Zetterberg
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  2. Jonathan M. Schott
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Corresponding author

Correspondence to Henrik Zetterberg.

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Competing interests

H.Z. has served at scientific advisory boards of Roche Diagnostics, Wave, Samumed and CogRx and is a co-founder of Brain Biomarker Solutions in Gothenburg AB, a GU Ventures–based platform company at the University of Gothenburg. J.M.S. has received research funding and PET tracer from AVID Radiopharmaceuticals (a wholly owned subsidiary of Eli Lilly); has consulted for Roche, Eli Lilly, Biogen and Merck; received royalties from Oxford University Press and Henry Stewart Talks; given education lectures sponsored by Eli Lilly, Biogen and GE; and serves on a Data Safety Monitoring Committee for Axon Neuroscience SE.

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Zetterberg, H., Schott, J.M. Biomarkers for Alzheimer’s disease beyond amyloid and tau. Nat Med 25, 201–203 (2019). https://doi.org/10.1038/s41591-019-0348-z

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