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Mast cell migration and organization in tissues depend on integrin–ECM interactions

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Many immune cell subsets move in an amoeboid fashion and do not require strong adhesive interactions with their surrounding when moving through interstitial tissue spaces. In stark contrast, we show that mast cells critically depend on integrin-mediated adhesion and interactions with the extracellular matrix to enable slow migration and site-specific positioning in tissues.

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Fig. 1: Loss of integrin functionality interferes with MC morphology, migration and positioning.

References

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This is a summary of: Kaltenbach, L. et al. Slow integrin-dependent migration organizes networks of tissue-resident mast cells. Nat. Immunol. https://doi.org/10.1038/s41590-023-01493-2 (2023).

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Mast cell migration and organization in tissues depend on integrin–ECM interactions. Nat Immunol 24, 899–900 (2023). https://doi.org/10.1038/s41590-023-01494-1

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