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Hacking the ‘Cellular Immunology Agency’: T cells caught in the act

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The identification of T cells recognizing antigen has historically depended on live-cell imaging. Through the use of neural network–based image analysis, T cell–priming events can now be identified in fixed archival tissues.

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Fig. 1: Liasrki and colleagues use CDM3 to identify antigen-recognition events in the kidneys of patients with lupus nephritis, revealing a role for pDCs in presenting antigen to CD4+ T cells1.

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Authors and Affiliations

  1. Department of Otolaryngology–Head and Neck Surgery, Department of Microbiology and Immunology, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, USA

    Matthew H. Spitzer

  2. Parker Institute for Cancer Immunotherapy, San Francisco, CA, USA

    Matthew H. Spitzer

  3. Chan Zuckerberg Biohub, San Francisco, CA, USA

    Matthew H. Spitzer

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  1. Matthew H. Spitzer
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Correspondence to Matthew H. Spitzer.

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Spitzer, M.H. Hacking the ‘Cellular Immunology Agency’: T cells caught in the act. Nat Immunol 20, 382–383 (2019). https://doi.org/10.1038/s41590-019-0354-9

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