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Extreme conservation encodes the structural dynamics and function of 5′ UTRs

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RNA is dynamic and can fold into multiple alternative conformations. A new study shows that cells control mRNA translation by regulating the stoichiometry of alternative RNA structures formed from extremely conserved sequences of 5′ untranslated regions and that this control may contribute to embryonic development.

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Fig. 1: h5UTRs may act as key regulators of translation during vertebrate development.

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Authors and Affiliations

  1. Department of Genetics and Genome Sciences, Institute for Systems Genomics, University of Connecticut Health Center, Farmington, CT, USA

    Amit Gupta & Jean-Denis Beaudoin

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  1. Amit Gupta
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  2. Jean-Denis Beaudoin
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Correspondence to Jean-Denis Beaudoin.

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The authors declare no competing interests.

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Gupta, A., Beaudoin, JD. Extreme conservation encodes the structural dynamics and function of 5′ UTRs. Nat Genet 53, 591–592 (2021). https://doi.org/10.1038/s41588-021-00869-0

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